Targeted intracellular protein delivery based on hyaluronic acid–green tea catechin nanogels

Liang, Kun; Ng, Shengyong; Lee, Fan; Lim, Joseph J.; Chung, Joo Eun; Lee, Su Seong; Kurisawa, Motoichi

doi:10.1016/j.actbio.2016.01.011

Cited by 81 publications

(57 citation statements)

References 38 publications

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“…Multimodal imaging-guided multistage targeted chemo-photothermal therapy [335] Optimized HA-methotrexate conjugates OA therapy [336] Steroids Steroid grafted on to HA Antioxidant delivery [337] EGF HA-EGF conjugate Chronic wound healing [338] Skin wound healing and regeneration [339] Anti-tumor necrosis factor-α Anti-tumor necrosis factor-α HA conjugate Early healing effects in a rat burn model [340] Epigallocatechin-3-O-Gallate HA-Epigallocatechin-3-O-Gallate conjugates injectable hydrogel Free radical scavenging [341] Sonic hedgehog Sonic hedgehog-HA conjugates Wound healing [342] Multivalent Sonic hedgehog conjugate Diabetic wound healing [343] Catechin Hyaluronic acid-green tea catechin nanogels Targeted intracellular protein delivery [344] Quercetin HA-quercetin conjugated micelles A tumor cell-targeted prodrug [345] Opiods HA-opioid conjugate Controlled delivery treatment for pain alleviation applications [346] Adv. Therap.…”

Section: Methotrexate Coated Magnetic Polydopamine Nanoparticlesmentioning

confidence: 99%

Glycosaminoglycan and Proteoglycan Biotherapeutics in Articular Cartilage Protection and Repair Strategies: Novel Approaches to Visco‐supplementation in Orthobiologics

Hayes

Melrose

2019

Advanced Therapeutics

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The aim of this study is to review developments in glycosaminoglycan and proteoglycan research relevant to cartilage repair biology and in particular the treatment of osteoarthritis (OA). Glycosaminoglycans decorate a diverse range of extracellular matrix and cell associated proteoglycans conveying structural organization and physico-chemical properties to tissues. They play key roles mediating cellular interactions with bioactive growth factors, cytokines, and morphogenetic proteins, and structural fibrillar collagens, cell interactive and extracellular matrix proteoglycans, and glycoproteins which define tissue function. Proteoglycan degradation detrimentally affects tissue functional properties. Therapeutic strategies have been developed to counter these degenerative changes. Neo-proteoglycans prepared from chondroitin sulfate or hyaluronan and hyaluronan or collagen-binding peptides emulate the interactive, water imbibing, weight bearing, and surface lubricative properties of native proteoglycans. Many neo-proteoglycans outperform native proteoglycans in terms of water imbibition, matrix stabilization, and resistance to proteolytic degradation. The biospecificity of recombinant proteoglycans however, provides precise attachment to native target molecules. Visco-supplements augmented with growth factors/therapeutic cells, hyaluronan, and lubricin (orthobiologicals) have the capacity to lubricate and protect cartilage, control inflammation, and promote cartilage repair and regeneration of early cartilage lesions and may represent a more effective therapeutic approach to the treatment of mild to moderate OA and deserve further study.Similar protective perineural net structures assembled from the lectican proteoglycan family and HA also occur in the CNS/PNS. These so called perineuronal nets are visualized by immunolocalization of MAb 1B5 (+) epitope in rat brain (e) and pericellular 1B5(+) epitope expression by isolated neurons (f). Scale bars 100 µm.

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Section: Methotrexate Coated Magnetic Polydopamine Nanoparticlesmentioning

confidence: 99%

Glycosaminoglycan and Proteoglycan Biotherapeutics in Articular Cartilage Protection and Repair Strategies: Novel Approaches to Visco‐supplementation in Orthobiologics

Hayes

Melrose

2019

Advanced Therapeutics

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“…Polysaccharide–polyphenol conjugates have been shown to form gel‐like networks that contain hydrophobic pockets capable of encapsulating bioactive components. Hyaluronic acid–EGCG hydrogel particles have been formed in aqueous solution that are capable of encapsulating bioactive agents (Liang and others ).…”

Section: Formation and Properties Of Conjugates‐based Delivery Systemsmentioning

confidence: 99%

Food‐Grade Covalent Complexes and Their Application as Nutraceutical Delivery Systems: A Review

Liu

Gao

et al. 2016

Comp Rev Food Sci Food Safe

262

107

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Food proteins, polysaccharides, and polyphenols are 3 major food constituents with distinctly different functional attributes. Many proteins and polysaccharides are capable of stabilizing emulsions and foams, thickening solutions, and forming gels, although they differ considerably in their abilities to provide these functional attributes. Many plant polyphenols exhibit beneficial physiological functions, such as antitumor, antioxidant, antibacterial, and antiviral properties. Proteins, polysaccharides, and polyphenols can form complexes with each other, which leads to changes in the functional and nutritional properties of the combined systems. Recently, there has been considerable interest in understanding and utilizing covalent interactions between polyphenols and biopolymers (proteins and polysaccharides). The binary or tertiary conjugates formed may be designed to have physicochemical properties and functional attributes that cannot be achieved using the individual components. This article provides a review of the formation, characterization, and utilization of conjugates prepared using proteins, polysaccharides, and polyphenols. It also discusses the relationship between the structural properties and functionality of the conjugates, and it highlights the bioavailability of bioactive compounds loaded in conjugate-based delivery systems. In addition, it highlights the main challenges to be considered when preparing and analyzing conjugates. This article provides an improved understanding of the chemical reactions that occur between major food ingredients and how they can be utilized to develop biopolymer-based delivery systems with enhanced functional attributes.

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“…By amidation with PEG (Su et al, 2011) and hyaluronic acid (Liang et al, 2016), the anticancer activity of CA and EGCG against breast and colon cancer was significantly enhanced in synergism with Bortezomib and Granzyme B, respectively. The conjugation of CA to Dex by free radical (Vittorio et al, 2012(Vittorio et al, , 2016a or laccase catalysis (Vittorio et al, 2016b) allows the obtainment of polymer conjugates suitable for the treatment of pancreatic cancer in vitro (Vittorio et al, 2012) and neuroblastoma in vivo (Vittorio et al, 2016a) with higher efficiency when compared with the free flavonoid.…”

Section: Polymer Conjugatesmentioning

confidence: 99%

Polyphenols delivery by polymeric materials: challenges in cancer treatment

et al. 2017

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Nanotechnology can offer different solutions for enhancing the therapeutic efficiency of polyphenols, a class of natural products widely explored for a potential applicability for the treatment of different diseases including cancer. While possessing interesting anticancer properties, polyphenols suffer from low stability and unfavorable pharmacokinetics, and thus suitable carriers are required when planning a therapeutic protocol. In the present review, an overview of the different strategies based on polymeric materials is presented, with the aim to highlight the strengths and the weaknesses of each approach and offer a platform of ideas for researchers working in the field.

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Targeted intracellular protein delivery based on hyaluronic acid–green tea catechin nanogels

Cited by 81 publications

References 38 publications

Glycosaminoglycan and Proteoglycan Biotherapeutics in Articular Cartilage Protection and Repair Strategies: Novel Approaches to Visco‐supplementation in Orthobiologics

Glycosaminoglycan and Proteoglycan Biotherapeutics in Articular Cartilage Protection and Repair Strategies: Novel Approaches to Visco‐supplementation in Orthobiologics

Food‐Grade Covalent Complexes and Their Application as Nutraceutical Delivery Systems: A Review

Polyphenols delivery by polymeric materials: challenges in cancer treatment

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