Biomimetic bone-like composites fabricated through an automated alternate soaking process

Strange, Daniel G. T.; Oyen, Michelle L.

doi:10.1016/j.actbio.2011.06.025

Cited by 34 publications

(27 citation statements)

References 35 publications

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“…Similar findings were obtained in other studies [519][520][521][522][523][524][525][526][527][528]. In 2011, the process was automated allowing deposition of substantial quantities of CaPO 4 with a minimum of labor and energy [529].…”

Section: Accepted Manuscriptsupporting

confidence: 79%

Calcium orthophosphate deposits: Preparation, properties and biomedical applications

Dorozhkin¹

2015

Materials Science and Engineering: C

246

122

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Section: Accepted Manuscriptsupporting

confidence: 79%

Calcium orthophosphate deposits: Preparation, properties and biomedical applications

Dorozhkin¹

2015

Materials Science and Engineering: C

246

122

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“…In this study we expand on previous work, the co-precipitation of HA -GEL [7], to create for the first time CaCO 3 -GEL composites on a variety of substrates. Furthermore, during the deposition of the CaCO 3 -GEL composite steady growth of the calcite crystals is observed with increasing numbers of cycles.…”

Section: Discussionmentioning

confidence: 97%

“…This lends itself to replicating the natural formation of a biomineralized composite, such as eggshell, where the mineral is heterogeneously nucleated on a collagenous membrane and in which some organic material is found throughout the biomineralized layer. In this study, we expand on our previous work that demonstrated the co-precipitation of a HA -GEL composite [7] and detail the deposition of an eggshell-like CaCO 3 -GEL composite using the ASP.…”

Section: Introductionmentioning

confidence: 89%

“…The ASP was automated using an inexpensive robotic crane built from parts from a Lego Mindstorms NXT kit (Lego Group, Denmark) with a mesh basket for holding glass cover slips as in [7]. Membrane samples that would curl up and cover the active surface if left in a basket were mounted by wrapping around a stainless steel disk and supported by a magnet with the active surface facing down.…”

Section: Automated Alternate Soaking Processmentioning

confidence: 99%

“…Mineral deposition during the ASP relies on layer-by-layer ion binding to the surface of the substrate while the rinse solution removes loose ions that would form solution precipitates. We recently modified the ASP for HA to include an organic component, gelatin (GEL), for co-precipitation of an organic-inorganic composite [7]. This lends itself to replicating the natural formation of a biomineralized composite, such as eggshell, where the mineral is heterogeneously nucleated on a collagenous membrane and in which some organic material is found throughout the biomineralized layer.…”

Section: Introductionmentioning

confidence: 98%

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Biomimetic Mineral-Protein Composites formed by an Automated Alternate Soaking Process

2012

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Biomineralized composite materials found in nature have a compromise of good mechanical properties and relatively small embodied energies in the process of their formation. The Alternate Soaking Process (ASP) is a laboratory technique that has only recently been applied to replicating composite biomineralization. The nexus of the ASP -heterogeneous nucleationmakes it ideal for replicating biominerals where the mineral is templated onto an organic substrate, such as occurs in avian eggshell. Here we demonstrate the deposition of a calcium carbonate gelatin composite on either glass cover slips or demineralized eggshell membranes using an automated ASP. SEM images and FTIR spectra of the resulting mineral show that by altering the amount of gelatin in the growth solutions the final organic component can be controlled accurately in the range of 1-10%, similar to that of natural eggshell. This study shows for the first time the co-precipitation of a CaCO 3 -gelatin composite by an ASP and that the organic fraction of this mineral can be tuned to mimic that of natural biomineralized composites.

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From Playroom to Lab: Tough Stretchable Electronics Analyzed with a Tabletop Tensile Tester Made from Toy‐Bricks

et al. 2016

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Toy bricks are an ideal platform for the cost‐effective rapid prototyping of a tabletop tensile tester with measurement accuracy on par with expensive, commercially available laboratory equipment. Here, a tester is presented that is not only a versatile demonstration device in mechanics, electronics, and physics education and an eye‐catcher on exhibitions, but also a powerful tool for stretchable electronics research. Following the “open‐source movement” the build‐up of the tester is described and all the details for easy reproduction are disclosed. A a new design of highly conformable all‐elastomer based graded rigid island printed circuit boards is developed. Tough bonded to this elastomer substrate are imperceptible electronic foils bearing conductors and off‐the‐shelf microelectronics, paving the way for next generation smart electronic appliances.

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Biomimetic bone-like composites fabricated through an automated alternate soaking process

Cited by 34 publications

References 35 publications

Calcium orthophosphate deposits: Preparation, properties and biomedical applications

Calcium orthophosphate deposits: Preparation, properties and biomedical applications

Biomimetic Mineral-Protein Composites formed by an Automated Alternate Soaking Process

From Playroom to Lab: Tough Stretchable Electronics Analyzed with a Tabletop Tensile Tester Made from Toy‐Bricks

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