Clinical profile of vitiligo patients and relationship with immuno-inflammatory markers

Mascarenhas, Marta Regina Machado; Oliveira, Mariana de Castro; Oliveira, Luise Fonseca de; Magalhães, Andréa Santos; Machado, Paulo Roberto Lima

doi:10.1016/j.abd.2023.03.007

Anais Brasileiros de Dermatologia

2024

DOI: 10.1016/j.abd.2023.03.007

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Clinical profile of vitiligo patients and relationship with immuno-inflammatory markers

Marta Regina Machado Mascarenhas,

Mariana de Castro Oliveira,

Luise Fonseca de Oliveira

et al.

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2024

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An Evaluation of the Hematological Markers of Systemic Inflammation and Oxidative Stress in Vitiligo: A Case-Control Study

Temel,

Orenay,

Karaosmanoglu

2024

Cureus

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Introduction Melanocyte dysfunction in vitiligo is considered to be due to genetics, inflammation, and autoimmunity. Research has shown that oxidative stress plays a significant role in triggering these conditions. Currently, there are several markers indicating hematological inflammation and oxidative stress. This study aimed to investigate the status of inflammation and oxidative stress markers in vitiligo. Methods This study included patients with vitiligo and age-gender-matched healthy controls. C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-high-density lipoprotein ratio (MHR) and extent of vitiligo were calculated and compared. Results The study included 138 participants (69 vitiligo and 69 controls). The mean was 41.46 years with a female predominance (55.1%). The patient group demonstrated higher levels of platelets, neutrophils, CRP, NLR, MLR, PLR, and HDL and lower levels of lymphocytes and HDL compared to the control group (p>0,05). The only significantly different value between the groups was MHR (p=0.03). The generalized vitiligo group demonstrated higher levels of platelets, neutrophils, monocytes, CRP, NLR, PLR, and MLR, and lower levels of lymphocytes and HDL compared to the localized group. The only significantly different values between the groups were MHR and MLR (p=0.02, p=0.03). Conclusion This study found that MHR and CRP values were higher in vitiligo patients. Additionally, MHR and MLR values were higher in patients with generalized vitiligo. These results suggest that MHR is a reliable indicator marker for systemic inflammation and oxidative stress in vitiligo.

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An Evaluation of the Hematological Markers of Systemic Inflammation and Oxidative Stress in Vitiligo: A Case-Control Study

Temel,

Orenay,

Karaosmanoglu

2024

Cureus

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Clinical profile of vitiligo patients and relationship with immuno-inflammatory markers

Cited by 1 publication

References 37 publications

An Evaluation of the Hematological Markers of Systemic Inflammation and Oxidative Stress in Vitiligo: A Case-Control Study

An Evaluation of the Hematological Markers of Systemic Inflammation and Oxidative Stress in Vitiligo: A Case-Control Study

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