IL-1β and IL-17 in cutaneous lupus erythematous skin biopsies: could immunohistochemicals indicate a tendency towards systemic involvement?

Lovato, Barbara Hartung; Fogagnolo, Leticia; Souza, Elemir Macedo de; Silva, Larissa Juliana Batista da; Velho, Paulo Eduardo Neves Ferreira; Cintra, Maria Leticia; Teixeira, Fernanda

doi:10.1016/j.abd.2023.02.007

Cited by 3 publications

(1 citation statement)

References 19 publications

(22 reference statements)

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“…Elevated levels of IL-1β are linked to a variety of skin pathologies such as psoriasis, acne vulgaris, and cutaneous lupus erythematosus. Thus, it is plausible that ILC3s could function similarly by interacting with neutrophils to drive skin inflammation [57][58][59][60][61]. Overall, more studies are needed to elucidate mechanisms by which neutrophils may initiate, repress, and/or promote crosstalk with ILCs in different skin conditions.…”

Section: Neutrophilsmentioning

confidence: 99%

Understanding Type 3 Innate Lymphoid Cells and Crosstalk with the Microbiota: A Skin Connection

To,

Oparaugo,

Kheshvadjian

et al. 2024

IJMS

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Innate lymphoid cells (ILCs) are a diverse population of lymphocytes classified into natural killer (NK) cells, ILC1s, ILC2s, ILC3s, and ILCregs, broadly following the cytokine secretion and transcription factor profiles of classical T cell subsets. Nonetheless, the ILC lineage does not have rearranged antigen-specific receptors and possesses distinct characteristics. ILCs are found in barrier tissues such as the skin, lungs, and intestines, where they play a role between acquired immune cells and myeloid cells. Within the skin, ILCs are activated by the microbiota and, in turn, may influence the microbiome composition and modulate immune function through cytokine secretion or direct cellular interactions. In particular, ILC3s provide epithelial protection against extracellular bacteria. However, the mechanism by which these cells modulate skin health and homeostasis in response to microbiome changes is unclear. To better understand how ILC3s function against microbiota perturbations in the skin, we propose a role for these cells in response to Cutibacterium acnes, a predominant commensal bacterium linked to the inflammatory skin condition, acne vulgaris. In this article, we review current evidence describing the role of ILC3s in the skin and suggest functional roles by drawing parallels with ILC3s from other organs. We emphasize the limited understanding and knowledge gaps of ILC3s in the skin and discuss the potential impact of ILC3-microbiota crosstalk in select skin diseases. Exploring the dialogue between the microbiota and ILC3s may lead to novel strategies to ameliorate skin immunity.

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Section: Neutrophilsmentioning

confidence: 99%

Understanding Type 3 Innate Lymphoid Cells and Crosstalk with the Microbiota: A Skin Connection

To,

Oparaugo,

Kheshvadjian

et al. 2024

IJMS

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Granzyme serine proteases in inflammation and rheumatic diseases

Aubert,

Jung,

Hiroyasu

et al. 2024

Nat Rev Rheumatol

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Role of Interleukin-17 in Predicting Activity of Rheumatoid Arthritis and Systemic Lupus Erythematosus

Samaan,

Taha,

Mahmoud

et al. 2024

Clin Med�Insights�Arthritis�Musculoskelet Disord

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Background: Although high serum levels of interleukin (IL)-17 and its producing cells have been found in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) in earlier research, it is still unclear how these findings relate to disease activity. Objectives: This study examines the link between serum levels of IL-17 and the activity of both RA and SLE. Design: This pilot case–control study included 100 patients with RA, 100 with SLE, and 100 healthy controls. Methods: The Disease Activity Score-28 (DAS28) scores assessed the activity of RA, whereas the Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) scores assessed SLE activity. All participants’ data were compared and correlated. Results: Serum levels of IL-17 were significantly higher in RA and SLE patients compared with the controls ( P < .001) and showed significantly positive correlations ( P < .001) with rheumatoid factor titer, anti-cyclic citrullinated peptide (anti-CCP) and DAS28 score among the RA patients. Although among SLE patients, they were significantly positively correlated ( P < .001) with anti-double-stranded DNA (anti-ds DNA) levels and the SLEDAI-2K scores, the best cut-off value of IL-17 for predicting moderate and high disease activity was > 175 pg/mL among RA patients and > 95 pg/mL among SLE patients. Conclusions: There is a significant correlation between RA and SLE activity and serum levels of IL-17. This discovery emphasizes IL-17 as a potential therapeutic target.

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IL-1β and IL-17 in cutaneous lupus erythematous skin biopsies: could immunohistochemicals indicate a tendency towards systemic involvement?

Cited by 3 publications

References 19 publications

Understanding Type 3 Innate Lymphoid Cells and Crosstalk with the Microbiota: A Skin Connection

Understanding Type 3 Innate Lymphoid Cells and Crosstalk with the Microbiota: A Skin Connection

Granzyme serine proteases in inflammation and rheumatic diseases

Role of Interleukin-17 in Predicting Activity of Rheumatoid Arthritis and Systemic Lupus Erythematosus

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