Pustular psoriasis triggered by therapy with atezolizumab and bevacizumab

Andrade, Mariani Magnus da Luz; Tejada, Guilherme Ladwig; Peruzzo, Juliano; Bonamigo, Renan Rangel

doi:10.1016/j.abd.2023.02.003

Cited by 3 publications

(1 citation statement)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, VEGFA has a key role in the pathogenesis of psoriasis. Some anti-VEGFA small molecule inhibitors, such as bevacizumab [ 12 ], can effectively improve psoriatic lesions, but the specific mechanisms of action need further study.…”

Section: Introductionmentioning

confidence: 99%

Vascular Endothelial Growth Factor A VEGFA Inhibition: An Effective Treatment Strategy for Psoriasis

Chen,

Tai,

Zhu

et al. 2023

IJMS

View full text Add to dashboard Cite

Psoriasis is an inflammatory skin disease mediated by the immune system and characterized by an inflammatory ring, also known as an epithelial immune microenvironment (EIME). The interaction between the epithelial tissue of the skin and the immune system has a crucial role in the immune cycle of psoriasis. Although the formation of new blood vessels in skin lesions provides energy support for the proliferation of epidermal keratinocytes, the role of angiogenesis in psoriasis has not been extensively studied. Vascular endothelial growth factor A (VEGFA) is a key regulator of angiogenesis that has an important role in the development of psoriasis. VEGFA promotes angiogenesis and directly stimulates epidermal keratinocytes and infiltrating immune cells, thus contributing to the progression of psoriasis. Measuring VEGFA levels to identify angiogenic characteristics in psoriasis patients may be a predictive biomarker for disease severity and response to anti-angiogenic therapy. Clinical data have shown that anti-angiogenic therapy can improve skin lesions in psoriasis patients. Therefore, this study aimed to uncover the underestimated role of blood vessels in psoriasis, explore the relationship between VEGFA and keratinocytes in the EIME, and inspire innovative drug therapies for the treatment of psoriasis.

show abstract

Section: Introductionmentioning

confidence: 99%