Measurement of pesticides in hair samples from pemphigus foliaceus and pemphigus vulgaris patients in Southeastern Brazil

Serra, Leonardo La; Salathiel, Adriana Martinelli; Lanaro, Rafael; MARTINIS, B DE; Roselino, Ana Maria Ferreira

doi:10.1016/j.abd.2022.10.010

Cited by 1 publication

(1 citation statement)

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“…Another suggested pathway is the loss of cell adhesion as a consequence of decreased skin muscarinic and nicotinic receptors expression ( 70 ). In a recent study, authors measured pesticides in hair samples of pemphigus patients and healthy controls confirming different distribution of contamination with organophosphates and/or organochlorines in hair samples in PV and PF and controls (6.3, 25.6, and 11.9%, respectively; p = 0.0437) ( 71 ). More conclusive data come from a very recent systematic review and meta-analysis from Chang and coworkers.…”

Section: Trigger Factorsmentioning

confidence: 85%

Pemphigus: trigger and predisposing factors

Moro,

Sinagra,

Salemme

et al. 2023

Front. Med.

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Pemphigus is a life-threatening autoimmune blistering disease affecting skin and mucous membranes. Despite its etiopathogenesis remains largely unknown, several trigger and predisposing factors have been reported. Pemphigus is caused by autoantibodies that target desmoglein 1 and desmoglein 3, impacting desmosome function. However, circulating autoantibodies are often the consequence of a precipitating factor that occurs in predisposed individuals. This review aims to describe and discuss almost all trigger and predisposing factors reported as possible or probable cause of the disease. Among the reported trigger factors that may induce or exacerbate pemphigus, we have found of particular interest: drug intake (especially thiol- and phenol-containing compounds), vaccines, infections, as well as some reports about pregnancy, radiations, emotional stress, pesticides and physical trauma. Moreover, we discuss the possible role of food intake in pemphigus onset and particular attention is given to dietary factors containing thiol, phenol and tannin compounds. A trigger factor is “the straw that breaks the camel’s back,” and often acts together with predisposing factors. Here we discuss how pemphigus onset may be influenced by genetic susceptibility and comorbidities like thyroid diseases, malignancies and other autoimmune disorders.To identify other hitherto unknown trigger and predisposing factors, well designed prospective studies are needed. In this context, future research should explore their connection with the aim to advance our understanding of pemphigus pathogenesis.

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Section: Trigger Factorsmentioning

confidence: 85%