Cutaneous lupus erythematosus: a review of etiopathogenic, clinical, diagnostic and therapeutic aspects

Vale, Everton Carlos Siviero do; Garcia, Lucas Campos

doi:10.1016/j.abd.2022.09.005

Cited by 12 publications

(26 citation statements)

References 71 publications

(318 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cutaneous inflammation is quite common in patients with SLE. 41 The activation of the innate and adaptive immune systems promotes skin tissue inflammation, thus resulting in cytotoxic damage. Accumulated damage resulting from chronic inflammation leads to the inability of keratinocytes and fibroblasts to produce crucial cellular components compared to their younger counterparts.…”

Section: Discussionmentioning

confidence: 99%

Genetically Proxied Autoimmune Diseases and the Risk of Facial Aging

Zhang,

Li,

Geng

et al. 2024

CCID

View full text Add to dashboard Cite

Purpose Previous studies have suggested a relationship between autoimmune diseases and the risk of facial skin aging. However, evidence from population-based studies on this topic is limited, leaving the causal association between these factors unknown. This study aimed to systematically evaluate the causal effects of 18 autoimmune diseases on the risk of facial skin aging, aim of providing strategies to mitigate early facial aging in patients with autoimmune diseases. Patients and Methods We conducted univariate Mendelian randomization (UVMR) analyses to examine the causal relationship between 18 autoimmune diseases and facial aging using publicly available summary data from genome-wide association studies (GWASs). We also conducted multivariate Mendelian randomization (MVMR) analyses to adjust for confounding factors, including smoking, alcohol consumption, and body mass index (BMI). Results The main inverse variance weighted (IVW) method revealed that genetically proxied ankylosing spondylitis (AS) (OR 1.017; 95% CI: 1.003–1.031; P =0.018), sicca syndrome (SS) (OR 1.008; 95% CI: 1.005–1.011; P = 2.66×10 −6 ), systemic lupus erythematosus (SLE) (OR 1.006; 95% 1.001–1.011; P =0.014), multiple sclerosis (MS) (OR 1.004; 95% CI: 1.001–1.007; P =0.021), primary sclerosing cholangitis (PSC) (OR 1.002; 95% CI: 1.000–1.004; P =0.023), and celiac disease (CeD) (OR 1.002; 95% CI: 1.001–1.004; P =0.009) were significantly associated with higher risk of facial aging. After adjusting for potential confounding factors, the association persisted between AS, SLE, and CeD. Conclusion These findings indicated that autoimmune diseases play a causal role in facial skin aging. Therefore, patients with autoimmune diseases should take appropriate measures to prevent early facial aging.

show abstract

Section: Discussionmentioning

confidence: 99%

Genetically Proxied Autoimmune Diseases and the Risk of Facial Aging

Zhang,

Li,

Geng

et al. 2024

CCID

View full text Add to dashboard Cite

show abstract

“…Etiopathogenesis of TLE has not been yet fully elucidated but is believed to involve a complex interplay between genetic, environmental, and immunological factors [19,21,22]. Ultraviolet (UV) radiation is a major triggering factor in most, but not all TLE patients [15,23].…”

Section: Etiopathogenesismentioning

confidence: 99%

“…Similar to other types of cutaneous lupus erythematosus, plasmacytoid dendritic cells (pDCs) recruitment is believed to be a major factor in the pathogenesis, with the resultant production of Interferon type I (IFN-I). The latter subsequently leads to the activation of T-lymphocytes and the induction of chemokines and cytokines [22,33].…”

Section: Etiopathogenesismentioning

confidence: 99%

“…As part of the spectrum of LE, the nosology of TLE has been evolving. Whereas rheumatological classification for LE is based on symptoms and assessment of systemic involvement, from a dermatological perspective, classification has been established in order to categorize the disease mainly according to the morphology of skin lesions [22,39,40].…”

Section: Classification Of Tlementioning

confidence: 99%

“…In the classification systems for dermatological purposes, chilblain lupus, lupus tumidus, and lupus profundus are predominantly classified as cutaneous-limited LE [22,39]. Since the first case described in the early 1900s, Gougerot and Burnier [41] described five patients with similar clinical features, such as erythematous, indurated, non-scarring lesions on the face with minimal surface changes.…”

Section: Classification Of Tlementioning

confidence: 99%

See 2 more Smart Citations

Tumid Lupus Erythematosus (TLE): A Review of a Rare Variant of Chronic Cutaneous Lupus Erythematosus (cCLE) with Emphasis on Differential Diagnosis

Daruish,

Ambrogio,

Foti

et al. 2024

Diagnostics

View full text Add to dashboard Cite

Tumid lupus erythematosus (TLE) has been the subject of heated debate regarding its correct nosographic classification. The definition of TLE has changed over time, varying according to the different studies performed. In this review, we address the initial definition of TLE, the changes that have taken place in the understanding of TLE, and its placement within the classification of cutaneous lupus erythematosus (CLE), with a focus on clinical, histopathological, immunophenotypical, and differential diagnosis aspects.

show abstract