Association of e-cadherin gene CDH1 polymorphism -160 C/A with susceptibility to develop vitiligo

Kubelis‐López, David Emmanuel; Zapata-Salazar, Natalia Aranza; Salinas-Santander, Mauricio; Sánchez‐Domínguez, Celia Nohemí; Morlett-Chávez, Jesús Antonio; Candiani, Jorge Ocampo

doi:10.1016/j.abd.2022.07.003

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2024

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“…CDH1, encoding E-cadherin, may be an important candidate gene for golden and silver feathers of Wenchang chickens. Research has found that before clinical lesions appear in vitiligo patients, E-cadherin between melanocytes and keratinocytes appears to have discontinuous distribution or disappears, resulting in the loss of melanocytes and the appearance of white spots on the skin ( Wagner et al., 2015 ; Kubelis-Lopez et al., 2023 ). Knockdown of ZMIZ1 (a golden feather candidate gene in Wenchang chickens) inhibits the proliferation and migration of melanocytes ( Li et al., 2020 ).…”

Section: Discussionmentioning

confidence: 99%