Comedogenic lupus: a rare variant of chronic cutaneous lupus erythematosus – case series

Carbamazepine‐induced comedonic lupus: A case report

“…Besides topical corticosteroids, benzoyl peroxide and both oral and topical retinoids, hydroxychloroquine has often been the preferred drug, with favourable clinical outcomes in documented cases. 2,3 Notably, in this case, resolution only occurred with cessation of carbamazepine (and commencement of levetiracetam) simultaneous to use of hydroxychloroquine. This patient failed to improve with antimalarial or retinoid therapy alone.…”

“…While some authors suggest the condition arises due to a breakdown of the pilosebaceous units, resulting in seborrheic areas and CD4 T-cell mediated epithelial hyperplasia, the definitive pathogenesis remains elusive. 2,3 Clinically, this disorder may masquerade as benign entities including trichoepithelioma, syringoma, Favre-Racouchot syndrome, nevus comedonicus, milia en plaque and acne vulgaris. 3 There is no gold standard treatment for CL.…”

“…2,3 Clinically, this disorder may masquerade as benign entities including trichoepithelioma, syringoma, Favre-Racouchot syndrome, nevus comedonicus, milia en plaque and acne vulgaris. 3 There is no gold standard treatment for CL. Photoprotection is imperative due to sun-induced exacerbation of comedones, sebum retention and lupus onset.…”

Cutaneous lupus erythematosus: a review of etiopathogenic, clinical, diagnostic and therapeutic aspects

“…It is often confused with acne vulgaris, nevus comedonicus, and nodular elastoidosis with cysts and comedones, which often delays diagnosis and treatment, resulting in inaesthetic scars. 37 , 38 , 39 …”