Serum interleukin-6 levels are increased in post-herpetic neuralgia: a single-center retrospective study

Lin, Ding Yu; Zhong, Changyang; Jiang, Quanlong; Liu, Yuan

doi:10.1016/j.abd.2022.03.007

Cited by 3 publications

(2 citation statements)

References 21 publications

(18 reference statements)

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“…Therefore, the data of these studies should be interpreted carefully. Among the reported studies, Ding Lin et al 31 found no significant difference in IL-10 levels between PHN and control groups, which is inconsistent with the studies of ShenMei Zhu et al 22 and Wei Chen et al 75 and the reason for the difference may be due to the use of different analytical methods. Yanrong Yuan et al 32 reported that CD8+ T cells did not show a remarkable difference between the two groups, which may be because 129 patients were included in the case group while only 31 patients were included in the control group, causing an insufficient statistical test.…”

Section: Discussionmentioning

confidence: 82%

Humoral Cytokine Levels in Patients with Herpes Zoster: A Meta-Analysis

Yue,

Yao

2024

JPR

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Background The neurocutaneous disease caused by the reactivation of varicella-zoster virus (VZV) is called herpes zoster (HZ). The virus remains in the spinal cord back root after the chickenpox disappears. Diminished immune function can reactivate VZV, causing severe neuropathic pain that can last for months or even years, leading to postherpetic neuralgia (PHN), which severely affects the patient’s quality of life. Much literature compares various cytokine levels in the body fluids HZ and PHN patients; however, no studies comprehensively evaluate them. Methods The Cochrane Library, PubMed, Web of Science, and Medline were screened for studies on cytokine levels in body fluids of HZ and PHN patients in the English language. Healthy individuals were selected as the control group, and the standardized mean difference (SMD) between the case and control groups was imputed using a fixed-effects or random-effects model and expressed as a 95% confidence interval (CI). The Newcastle-Ottawa Scale (NOS) was used to assess article quality. Results This meta-analysis included 13 articles with 1373 participants. Compared with the control group, the HZ group had significantly higher levels of interleukin (IL)-4, IL-6, IL-10, Hcy, and C-reactive protein (CRP), whereas the levels of CD3+ T and CD4+ T lymphocytes were reduced. Additionally, PHN patients had significantly higher levels of IL-6 and IL-1β compared with the control group. Conclusion This meta-analysis provides compelling evidence that CRP, Hcy, IL-1β, IL-4, IL-6, IL-8, and IL-10 are associated with the genesis and development of HZ and PHN. These markers can be used to improve the diagnosis and treatment of these diseases.Furthermore, for making the results more convincing, it is necessary to harmonize sample acquisition techniques and analytical methods and also require larger, more rigorously designed studies with broader subgroups and sex/age-matched controls.

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Section: Discussionmentioning

confidence: 82%

Humoral Cytokine Levels in Patients with Herpes Zoster: A Meta-Analysis

Yue,

Yao

2024

JPR

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“…The level of IL-2 in patients with pathological neuralgia was higher than that in healthy individual, and the level of IL-6 was lower. [34] The study [35] found that the level of serum IL-6 in patients with PHN increased, which can be used as an indicator of the severity of PHN. This study suggests that AHP can increase serum IL-10 levels in patients with PHN and reduce serum IL2 and IL6 levels in patients with PHN.…”

Section: Discussionmentioning

confidence: 99%

Acupoint herbal patching for postherpetic neuralgia: A systematic review and meta-analysis

Pu,

Lu,

et al. 2024

Medicine

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Background: This study aimed to systematically evaluate the clinical effectiveness and safety of acupoint herbal patching in the treatment of postherpetic neuralgia. Methods: Eight databases including PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, Wan-Fang Database, China Biomedical Literature Service System, and Chongqing VIP Chinese Science were searched. The search time was set to October 2023. Two researchers independently screened the literature according to the inclusion and exclusion criteria; extracted the basic information, acupoints, Chinese herbal medicine, pain score, sleep score, depression score, and other information of the subjects, and independently assessed the risk of bias by 2 researchers. Meta-analysis of the included studies was performed using the StataMP 16 software. Results: Fifteen studies with 1362 participants were included in this meta-analysis. Ashi is the acupoint frequency at the forefront, and Borneol is the Chinese herbal medicine frequency at the forefront. The acupoint herbal patching group showed significant improvements in visual analog score (SMD: −2.09; 95% Cl: −2.77, −1.42; P < .001), sleep score (SMD: −1.58; 95% Cl: −2.11, −1.05; P < .001), depression score (SMD: −1.61; 95% Cl: −2.22, −0.99; P < .001), Chinese medicine syndrome score (SMD: −2.32; 95% Cl: −2.84, −1.80; P = .06), dermatology life quality index (weighted mean differences: −4.11; 95% Cl: −4.58, −3.63; P = .98), and related laboratory indicators compared to the control group, and the total effective rate was significantly higher (relative risk: 1.20; 95% confidence interval: 1.15, 1.26; P = .99) than the control group. Two studies reported adverse reactions, but the 2 groups were not statistically significant. Conclusions: Acupoint herbal patching intervention in postherpetic neuralgia is effective in improving the pain, sleep, anxiety, depression, quality of life of patients, and related laboratory indicators.

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Trigeminal Postherpetic Neuralgia: From Pathophysiology to Treatment

Niemeyer,

Harlander-Locke,

Bubak

et al. 2024

Curr Pain Headache Rep

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Purpose of Review Trigeminal postherpetic neuralgia (TG-PHN) is a neuropathic pain condition complicating herpes zoster (HZ) attributed to the trigeminal nerve. It poses significant challenges due to its persistent and debilitating nature. This review explores the clinical characteristics of TG-PHN, analyzes its pathophysiological underpinnings, and addresses existent and potential therapies. Recent Findings TG-PHN is one of the most common and complex PHN locations. It has distinguishing clinical and pathophysiological characteristics, starting with viral triggered injuries to the trigeminal ganglion (TG) and peripheral tissue and involving the ascending and descending brain modulation pathways. Current therapies include vaccines, oral and topical medications, and interventional approaches, like nerve blocks and neurostimulation. Summary This review covers TG-PHN’s clinical and physiological components, treatment options, and potential future targets for improved management. By exploring the complexities of this condition, we aim to contribute to developing more effective and targeted therapies for patients suffering from trigeminal PHN.

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Serum interleukin-6 levels are increased in post-herpetic neuralgia: a single-center retrospective study

Cited by 3 publications

References 21 publications

Humoral Cytokine Levels in Patients with Herpes Zoster: A Meta-Analysis

Humoral Cytokine Levels in Patients with Herpes Zoster: A Meta-Analysis

Acupoint herbal patching for postherpetic neuralgia: A systematic review and meta-analysis

Trigeminal Postherpetic Neuralgia: From Pathophysiology to Treatment

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