Telomere length, oxidative and epigenetic changes in blood DNA of patients with exacerbated psoriasis vulgaris

Sericin coated thin polymeric films reduce keratinocyte proliferation via the mTOR pathway and epidermal inflammation through IL17 signaling in psoriasis rat model

“…SERPINA3 gene mutation or upregulation of serpinA3 is a predisposing factor of pustular psoriasis 56 3* 18.2 134 2.90 TRFE_RAT SerotranScFerrin SerotranScFerrin is an abundant blood plasma glycoprotein, which is upregulated in psoriatic skin, and is involved in cellular proliferation 57 3* 48.9 1218 2.63 HEMO_RAT Hemopexin Hemopexin is the plasma protein with the highest binding affinity to heme, which is elevated in respiratory diseases, particularly asthma and chronic obstructive pulmonary disease (COPD) 58 1 # 39.6 546 2.13 HSP72_RAT Heat shock-related 70 kDa protein 2 (HSPA2) HSPA2 is a stress-induced chaperone, contributing to the early step of keratinocyte differentiation and maintenance of epidermal homeostasis 59 3 # 22.1 117 2.00 Down-regulation FRAP_RAT Serine/threonine-protein kinase mTOR (mTOR) mTOR is a serine/threonine kinase, that regulates cell growth, autophagy, and the actin cytoskeleton in response to the stimuli and cytokines. The mTOR signaling proteins are upregulated in psoriatic skin and proliferation keratinocytes 20 , 22 3* 19.3 120 22.50 TEP1_RAT Telomerase protein component 1 (TEP1) TEP1 is a component of the ribonucleoprotein complex responsible for telomerase activity enhancement in psoriasis 60 , 61 3* 14.5 106 6.00 …”