Sebaceous nevus of Jadassohn: review and clinical-surgical approach

Neto, Manoel Pereira da Silva; Assis, Barbara Rodovalho de; Andrade, Gustavo Rodrigues

doi:10.1016/j.abd.2021.11.001

Cited by 14 publications

(8 citation statements)

References 23 publications

(67 reference statements)

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“…Histopathology in the postpubertal stage reveals epidermal hyperplasia, hyperplastic sebaceous glands, and dilated ectopic apocrine glands. 6,7 Secondary skin and appendageal tumors arise in .50% of patients with nevus sebaceus. 8 Although most of these tumors are benign, clinical monitoring is essential and systemic workup may be required.…”

Section: Discussionmentioning

confidence: 99%

Linear Alopecia in a Healthy Young Woman: Answer

Samra,

Miteva

2024

The American Journal of Dermatopathology

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Section: Discussionmentioning

confidence: 99%

Linear Alopecia in a Healthy Young Woman: Answer

Samra,

Miteva

2024

The American Journal of Dermatopathology

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“…It manifests as a skin color or yellow-brown plaque that can be partial alopecic, which can change appearance and color in the second stage of puberty due to hormonal influence. The third stage of development appears in adults and is associated with an increased risk of secondary benign or malignant tumors [ 6 ]. In our patient, the scalp lesion had been present from birth, had grown during the patient’s teenage years, and had changed its appearance over the past three years.…”

Section: Discussionmentioning

confidence: 99%

“…The diagnosis of NSJ is usually clinical, and the follow-up and management of these lesions are unclear due to the risk of developing malignancies. Therefore, some authors recommend closer monitoring and excision only for aesthetic purposes or in cases where malignant change is suspected, rather than prophylactic surgery in late childhood or adolescence [ 6 ]. In our case, the lesion changed its appearance in the fourth decade of the patient’s life.…”

Section: Discussionmentioning

confidence: 99%

“…In adulthood, NSJ is associated with an increased risk of secondary benign, and more often, malignant tumors [ 4 , 5 ]. Trichoblastoma (TB) and syringocystadenoma papilliferum are the most common benign tumors, but NSJ can also be associated with trichilemmoma, sebaceous adenoma, desmoplastic trichilemmoma, apocrine adenoma, or poroma [ 6 , 7 ]. Trichoblastoma is a benign skin tumor that develops from follicular germinative cells and can appear alone or in conjunction with NSJ.…”

Section: Introductionmentioning

confidence: 99%

“…The most frequent malignant tumor is basal cell carcinoma (BCC), but other forms of carcinoma, including squamous cell carcinoma (SCC) and adnexal carcinoma, may also be present [ 6 , 7 ]. BCC is a common malignant tumor of the skin that develops from the cells of the basal layer or the appendages.…”

Section: Introductionmentioning

confidence: 99%

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Nevus Sebaceous of Jadassohn in Adults—Can Reflectance Confocal Microscopy Detect Malignant Transformation?

et al. 2023

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Nevus sebaceous of Jadassohn (NSJ) is a rare congenital lesion that affects the adnexal structures of the skin. It is typically located on the scalp and face of females and presents as a well-defined, slightly elevated, yellow lesion. It is also linked to a high risk of secondary tumors, which are more frequently benign than malignant. In vivo reflectance confocal microscopy (RCM) is a non-invasive imaging technique that provides a horizontal image of the skin with a resolution similar to histology. We report a case of basal cell carcinoma (BCC) developed in an NSJ with its dermoscopic, confocal, and histopathological features. A 49-year-old female presented with a well-circumscribed, 1 cm-diameter verrucous, yellowish lesion surrounded by a poorly defined, slightly erythematous, translucent plaque, located on the scalp in the temporoparietal region, which had been present since birth, grew at puberty, and changed its appearance in the last three years. Dermoscopy of the central lesion revealed yellow globules grouped into clusters, with peripheral linear and arborescent thin vessels, surrounded by several translucent nodular lesions with fine, arborizing vessels. RCM examination showed large, monomorphic cells with a hyperreflective periphery and a hyperreflective center located on the central lesion, corresponding to sebocytes, surrounded by multiple dark silhouettes lined with hyperreflective bands of thickened collagen, corresponding to tumor islands. The histopathological findings confirmed the diagnosis of BCC developed on an NJS. RCM can be a useful technique for the non-invasive examination and monitoring of these lesions, taking into account their transformation risk and preventing unnecessary excisions that might have a detrimental aesthetic impact on patients.

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