Interleukin-17A in Egyptian leprosy patients: a clinical, genetic, and biochemical study

Farag, Azza Gaber Antar; Labeeb, Azza Zagloul; Gerges, Amany Nagy Abdalla; Elshaib, Mustafa Elsayed

doi:10.1016/j.abd.2021.09.016

Cited by 3 publications

(3 citation statements)

References 18 publications

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“…In leprosy, Farag et al . have demonstrated that IL17A rs2275913 genotype GG was associated with significantly increased IL-17A levels in Egyptian patients [ 57 ]. Finally, another study by Li et al revealed that IL-17A polymorphisms may influence hepatocellular carcinoma risk in chronic hepatitis B virus infection via regulating IL-17A production [ 58 ].…”

Section: Discussionmentioning

confidence: 99%

An elevated level of interleukin-17A in a Senegalese malaria cohort is associated with rs8193038 IL-17A genetic variant

Thiam,

Diop,

Coulonges

et al. 2024

BMC Infect Dis

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Malaria infection is a multifactorial disease partly modulated by host immuno-genetic factors. Recent evidence has demonstrated the importance of Interleukin-17 family proinflammatory cytokines and their genetic variants in host immunity. However, limited knowledge exists about their role in parasitic infections such as malaria. We aimed to investigate IL-17A serum levels in patients with severe and uncomplicated malaria and gene polymorphism’s influence on the IL-17A serum levels. In this research, 125 severe (SM) and uncomplicated (UM) malaria patients and 48 free malaria controls were enrolled. IL-17A serum levels were measured with ELISA. PCR and DNA sequencing were used to assess host genetic polymorphisms in IL-17A. We performed a multivariate regression to estimate the impact of human IL-17A variants on IL-17A serum levels and malaria outcomes. Elevated serum IL-17A levels accompanied by increased parasitemia were found in SM patients compared to UM and controls (P < 0.0001). Also, the IL-17A levels were lower in SM patients who were deceased than in those who survived. In addition, the minor allele frequencies (MAF) of two IL-17A polymorphisms (rs3819024 and rs3748067) were more prevalent in SM patients than UM patients, indicating an essential role in SM. Interestingly, the heterozygous rs8193038 AG genotype was significantly associated with higher levels of IL-17A than the homozygous wild type (AA). According to our results, it can be concluded that the IL-17A gene rs8193038 polymorphism significantly affects IL-17A gene expression. Our results fill a gap in the implication of IL-17A gene polymorphisms on the cytokine level in a malaria cohort. IL-17A gene polymorphisms also may influence cytokine production in response to Plasmodium infections and may contribute to the hyperinflammatory responses during severe malaria outcomes.

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Section: Discussionmentioning

confidence: 99%

An elevated level of interleukin-17A in a Senegalese malaria cohort is associated with rs8193038 IL-17A genetic variant

Thiam,

Diop,

Coulonges

et al. 2024

BMC Infect Dis

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“…In BL, Th17 cells play a protective role in the immune response 13,22 secreting IFN-γ, IL-4 and IL-5 13 . Conflicting data concerning IL-17 levels have been reported, suggesting decreased levels in the serum of patients with leprosy 23,24 , whereas other studies 13,14,17,25 have reported higher levels in the TT/BT polar forms than in the LL form [11][12][13][14]25,26 . Furthermore, one study concerning IL-17F identified higher levels in non-reactional patients than in healthy controls, suggesting the greater the bacillary load, the greater the secretion of IL-17F 17 .…”

Section: Th17 Levels In the Clinical Forms Of Leprosymentioning

confidence: 95%

“…Concerning IL-17A gene polymorphism, genetic factors influence the type of host immune response against the bacillus. Farag et al 25 showed that, while IL-17A gene polymorphisms were not significantly associated with genetic susceptibility to leprosy, the GG genotype and G allele of IL-17A were associated with progression to the LL form.…”

Section: Introductionmentioning

confidence: 99%

Th17 Cells and Cytokines in Leprosy: Understanding the Immune Response and Polarization

Zaniolo,

Damazo

2023

Rev. Soc. Bras. Med. Trop.

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While there are conflicting data concerning interleukin (IL)-17 levels in the serum of patients with leprosy compared with those in healthy controls, higher levels have been more evident in the tuberculoid clinical form of leprosy and type 1 reactions. This review aimed to highlight the role of Th17 cells and their cytokines in leprosy. Cytokines such as IL-1β and IL-23 induce Th17, while transforming growth factor beta and IL-10 inhibit Th17, indicating that the balance between Th17 and regulatory T cells is crucial for leprosy polarization. However, more comprehensive paired studies are required to better elucidate the role of Th17 cells in leprosy.

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An elevated level of Interleukin-17A in a Senegalese malaria cohort is associated with rs8193038 IL-17A genetic variant

Thiam

Diop

COULONGES

et al. 2023

Preprint

View full text Add to dashboard Cite

Malaria infection is a multifactorial disease partly modulated by host immuno-genetic factors. Recent evidence has demonstrated the importance of Interleukin-17 family proinflammatory cytokines and their genetic variants in host immunity. However, limited knowledge exists about their role in parasitic infections such as malaria. We aimed to investigate IL-17A serum levels in patients with severe and uncomplicated malaria and the gene polymorphism’s influence on the IL-17A serum levels. 125 severe (SM) and uncomplicated (UM) malaria patients and 48 free malaria controls were enrolled in this research. IL-17A serum levels were measured with ELISA. PCR and DNA sequencing were used to assess host genetic polymorphisms in IL-17A. We performed a multivariate regression to estimate the impact of human IL-17A variants on IL-17A serum level and malaria outcome. Elevated serum IL-17A levels accompanied by increased parasitemia were found in SM patients compared to UM and controls (P < 0.0001). Also, the IL-17A levels were lower in SM patients who were deceased than in those who survived. In addition, the minor allele frequencies (MAF) of two IL-17A polymorphisms (rs3819024 and rs3748067) were more prevalent in SM patients than UM patients indicating an essential role in SM. Interestingly, the heterozygous rs8193038 AG genotype was significantly associated with higher levels of IL-17A than the homozygous wild type (AA). According to our results, it can be concluded that the IL-17A gene rs8193038 polymorphism significantly affects IL-17A gene expression. Our results fill a gap in the implication of IL-17A gene polymorphisms on the cytokine level in a malaria cohort. IL-17A gene polymorphisms also may influence cytokine production in response to Plasmodium infections and may contribute to the hyperinflammatory responses during severe malaria outcomes.

show abstract

Interleukin-17A in Egyptian leprosy patients: a clinical, genetic, and biochemical study

Cited by 3 publications

References 18 publications

An elevated level of interleukin-17A in a Senegalese malaria cohort is associated with rs8193038 IL-17A genetic variant

An elevated level of interleukin-17A in a Senegalese malaria cohort is associated with rs8193038 IL-17A genetic variant

Th17 Cells and Cytokines in Leprosy: Understanding the Immune Response and Polarization

An elevated level of Interleukin-17A in a Senegalese malaria cohort is associated with rs8193038 IL-17A genetic variant

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