Darier disease: the use of dermoscopy in monitoring acitretin treatment

Silva-Hirschberg, Catalina; Cabrera, Raúl; Rollán, María Paz; Castro, Alex

doi:10.1016/j.abd.2021.05.021

Cited by 3 publications

(3 citation statements)

References 9 publications

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“…Dermoscopy can also be used to assess treatment response in patients with HHD and DD [ 24 , 36 ]. There is one publication in the literature that evaluated CO 2 laser in patients with HHD using dermoscopy [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

“…There is one publication in the literature that evaluated CO 2 laser in patients with HHD using dermoscopy [ 24 ]. Also, there is one case report assessing dermoscopy as a tool for monitoring patients with DD during acitretin treatment [ 36 ]. These case reports showed that dermoscopy can be a useful method to evaluate treatment of HHD and DD; however, research with a larger study group is needed.…”

Section: Discussionmentioning

confidence: 99%

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Dermoscopy as a Noninvasive Diagnostic Tool for Hailey-Hailey Disease and Darier Disease

Kurzeja,

Rakowska,

Jasinska

et al. 2023

Dermatol Ther (Heidelb)

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Introduction Hailey-Hailey disease (HHD) and Darier disease (DD) are rare genetic disorders for which differential diagnosis, especially in less obvious cases, can be difficult. The diagnosis is based on the clinical picture and family history, and is confirmed by histopathologic examination. Dermoscopy is a noninvasive technique that is primarily used at the present time to diagnose skin cancers. However, in the past few years this technique has also been increasingly used as a noninvasive diagnostic tool of inflammatory skin diseases. The aim of the study was to evaluate whether dermoscopy is a useful noninvasive diagnostic tool for HHD and DD. Methods We performed an observational retrospective case series study involving 13 patients with HHD ( n = 8) and DD ( n = 5). The presence or absence of standardized dermoscopic features of inflammatory diseases (according to International Dermoscopy Society [IDS] guidelines) was assessed in these patients. Results The most distinctive feature of HHD was white clouds separated by pink furrows, visible in all cases (8/8; 100.0%). Another distinctive clue of HHD was the crumbled fabric pattern seen in six patients with HHD (6/8; 75.0%). These dermoscopic findings were not present in patients with DD. The most typical features of DD in the dermoscopic examination was star-like or oval-shaped yellow areas surrounded by whitish halo, visible in all patients (5/5; 100.0%). Another distinctive dermoscopic clue of DD was pinkish homogeneous structureless background, which was present in all patients (5/5, 100.0%). These latter two features were not observed in patients with HHD. Conclusion Dermoscopy reveals distinctive features of HHD and DD, respectively. Therefore, we conclude that dermoscopy can be an excellent complementary noninvasive tool in the diagnostic process of patients with HHD and DD.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Dermoscopy as a Noninvasive Diagnostic Tool for Hailey-Hailey Disease and Darier Disease

Kurzeja,

Rakowska,

Jasinska

et al. 2023

Dermatol Ther (Heidelb)

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“…The ducts were lined by two rows of epithelial cells, with a characteristic comma-shaped/tadpole-like pattern, and filled with eosinophilic amorphous substances. In Darier disease, the dermoscopic evaluation showed comedo-like openings with a central polygonal yellowish/brownish structure, surrounded by a whitish halo on a pink background [10]. Histopathology findings showed acantholysis above the basal layer of the epidermis and dyskeratotic keratinocytes.…”

Section: Es Is Easily Misdiagnosis Clinically and May Be Confused Withmentioning

confidence: 99%

Three cases of eruptive syringoma with dermoscopic features

Jiang¹,

Jiang²,

Guo³

et al. 2022

J Clin Images Med Case Rep

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Syringoma is a benign adnexal neoplasm originating from the intraepidermal eccrine duct. Eruptive Syringoma (ES) is a rare variant that is characterized by skin-colored to reddish-brown and shiny papules. Here we report three cases of ES, one of them initially misdiagnosed as Darier disease. Dermoscopy showed light brown pigment networks and dotted or linear vessels. All these cases were confirmed as ES by histopathological examination, highlighting the importance of histopathological and dermoscopic evaluation.

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