Spontaneous regression of Merkel cell carcinoma with positive detection of Merkel cell polyomavirus by PCR and immunohistochemistry

Bellott, Thiago Rubim; Luz, Flávio Barbosa; Varella, Rafael Brandão; Rochael, Mayra Carrijo

doi:10.1016/j.abd.2021.04.018

Cited by 1 publication

(1 citation statement)

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“…2 The regression observed in Merkel Cell Carcinoma is a rare phenomenon, with less than 40 descriptions found in the literature. 11 Several risk factors are observed in the pathogenesis of MCC, with Merkel Cell Polyomavirus (MCPyV) being related to the development of most cases of MCC. In addition to other factors such as advanced age, ultraviolet radiation and chronic immunosuppression (8% of patients with CCM hematological malignancy, solid organ transplantation or HIV/AIDS).…”

Section: Introductionmentioning

confidence: 99%

Regression of a Merkel cell carcinoma in the hypothenar region: a case report

Trocoli-Couto¹,

Santos²,

Farias³

et al. 2023

JCPCR

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Merkel cell carcinoma (MCC) is a rare and aggressive cutaneous neuroendocrine neoplasm with a poor prognosis. It usually affects white-skinned old individuals in areas chronically exposed to solar radiation. MCC's spontaneous regression is a mechanism not yet clearly understood. It is a known fact and a rare occurrence in MCC, after biopsy or incomplete resection has been performed. Considering the rarity of this type of occurrence, we will describe a clinical case treated at Hospital da Baleia, Belo Horizonte, State of Minas Gerais, Brazil. The report will address a male patient, 72 years old, leukodermic, with systemic arterial hypertension, type 2 diabetes mellitus and vitiligo. He was referred to the surgery department with a lesion in the right hypothenar region with an onset 4 months before admission, and presented with tumor regression after biopsy. Data was assembled through the analysis of the patient's medical record, after declared authorization, open interview with the patient at the time of follow-up appointments to the hospital's outpatient clinic, and analysis of photographic records of the injury before and after the instituted therapy.

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Section: Introductionmentioning

confidence: 99%