Uncommon subtypes of frontal fibrosing alopecia: retrospective analysis of clinical characteristics and prognosis

Rocha, Vanessa Barreto; Machado, Carla Jorge; Contin, Letícia Arsie

doi:10.1016/j.abd.2021.02.009

Cited by 1 publication

(4 citation statements)

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“…84 Rocha et al found that the most common comorbidities of FFA were hypertension, DM, dyslipidemia, and hypothyroidism, however, they found no significant differences between FFA patients and controls. 77 Another small study found both systolic and diastolic BP were significantly higher in patients with FFA compared to controls. 85 Overall, the question regarding CV risk in relation to FFA has not been adequately explored and larger studies investigating this relationship as well as associated comorbidities are necessary before considering the impact of FFA treatment on the potential mitigation of CV risk factors.…”

Section: Frontal Fibrosing Alopecia (Ffa)mentioning

confidence: 97%

“…Rocha et al found that the most common comorbidities of FFA were hypertension, DM, dyslipidemia, and hypothyroidism, however, they found no significant differences between FFA patients and controls 77 . Another small study found both systolic and diastolic BP were significantly higher in patients with FFA compared to controls 85 …”

Section: Scarring Alopeciasmentioning

confidence: 98%

“…77 It primarily affects postmenopausal women, though there is increasing incidence in men and skin of colour patients and it is reportedly the most common primary cicatricial alopecia. [77][78][79] The overall prevalence appears to be increasing in recent years and has been estimated based on one NYC cohort to be 0.012%. 78,80,81 The pathogenesis of FFA is not yet completely clear.…”

Section: Frontal Fibrosing Alopecia (Ffa)mentioning

confidence: 99%

“…FFA is a primary cicatricial alopecia characterised by progressive band‐like frontotemporal hairline regression, often accompanied by madarosis (eyebrow loss), and shares histopathological characteristics with LPP 77 . It primarily affects postmenopausal women, though there is increasing incidence in men and skin of colour patients and it is reportedly the most common primary cicatricial alopecia 77–79 . The overall prevalence appears to be increasing in recent years and has been estimated based on one NYC cohort to be 0.012% 78,80,81 .…”

Section: Scarring Alopeciasmentioning

confidence: 99%

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Cardiovascular risk in patients with scarring and nonscarring alopecias: Assessing the current state of evidence

Sally,

Robinson,

Orlow

et al. 2023

JEADV Clinical Practice

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Alopecia is traditionally classified into scarring and nonscarring subtypes, with etiopathologies ranging from androgen‐mediated to immuno‐inflammatory. Over 50% of men and almost 50% of women will experience some form of hair loss in their lifetime. Given this prevalence and the psychosocial significance of hair, understanding the pathophysiology and comorbidities of different types of hair loss is imperative. Other proinflammatory dermatologic disorders, such as psoriasis, are recognised to have systemic manifestations including an increased risk of cardiovascular (CV) disease, and are now considered CV risk‐enhancing conditions. With increased recognition of the importance of systemic inflammation in promoting atherosclerosis, high prevalence, and improved treatment strategies, there is increased interest in establishing whether a similar association between alopecia and cardiovascular disease (CVD) exists. In this manuscript, we aim to review the current literature regarding CV risk in androgenic alopecia (AGA) and alopecia areata (AA). Additionally, we review the literature for cicatricial alopecias and highlight the need for more research into their potential associations with CV risk. Evidence from the identified AGA publications suggests an association of AGA with CV risk factors including hypertension, dyslipidemia, and insulin resistance, as well as with coronary artery disease. For AA, most of the identified studies found an association between AA and CV risk, though the relationships were not always statistically significant. Research on cicatricial alopecias and CV risk is limited and often contradictory. There is great need for more studies regarding the association between various types of alopecia and the development of CVD, and potential mechanisms. Particularly needed are more studies of cicatricial alopecias and potential associated CV risk. While some literature suggests that patients with alopecia have an increased risk of CVD, the lack of concrete evidence represents a notable gap in our current understanding.

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Section: Frontal Fibrosing Alopecia (Ffa)mentioning

confidence: 97%

Section: Scarring Alopeciasmentioning

confidence: 98%