Update on human papilloma virus - part I: epidemiology, pathogenesis, and clinical spectrum

Magalhães, Geraldo Magela; Vieira, Érica Cristina; Garcia, Lucas Campos; Carvalho-Leite, Maria de Lourdes Ribeiro de; Guedes, Antônio Carlos Martins; Araújo, Marcelo Grossi

doi:10.1016/j.abd.2020.11.003

Cited by 30 publications

(31 citation statements)

References 48 publications

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“…Human papillomavirus (HPV) is a non-enveloped tumor DNA virus with a genome of about 8 kb and is the agent of a common sexually transmitted infection globally. Although the infection clears, persistent infection leads to tumor development [162]. HPV infection occurs in the cutaneous or mucosal epithelium, especially in the genital tract.…”

Section: Human Papillomavirus (Hpv)mentioning

confidence: 99%

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Viral Manipulation of the Host Epigenome as a Driver of Virus-Induced Oncogenesis

2021

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Tumorigenesis due to viral infection accounts for a high fraction of the total global cancer burden (15–20%) of all human cancers. A comprehensive understanding of the mechanisms by which viral infection leads to tumor development is extremely important. One of the main mechanisms by which viruses induce host cell proliferation programs is through controlling the host’s epigenetic machinery. In this review, we dissect the epigenetic pathways through which oncogenic viruses can integrate their genome into host cell chromosomes and lead to tumor progression. In addition, we highlight the potential use of drugs based on histone modifiers in reducing the global impact of cancer development due to viral infection.

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Section: Human Papillomavirus (Hpv)mentioning

confidence: 99%

“…Persistent infection accounts for 70% of cervical cancer and 90% of genital warts. Other neoplasms directly connected to HPV infection include anal, penile, vulvar, vaginal and oropharyngeal cancer [162].…”

Section: Human Papillomavirus (Hpv)mentioning

confidence: 99%

Viral Manipulation of the Host Epigenome as a Driver of Virus-Induced Oncogenesis

2021

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“…Cutaneous warts are common skin conditions caused by some strains of human papilloma virus [ 1 ]. Plantar warts can be painful and disabling, limiting ambulation and daily activities, and their management is often challenging because of the risk of treatment failure and recurrence.…”

Section: Introductionmentioning

confidence: 99%

Spreading Allergic Contact Dermatitis to Tea Tree Oil in an Over-the-Counter Product Applied on a Wart

et al. 2022

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Tea tree oil is an essential oil obtained by distillation from the leaves and terminal branchlets of Melaleuca alternifolia and is now present in numerous products for body care and self-medication. We report a case of allergic contact dermatitis to tea tree oil in a young man who was applying a lotion containing tea tree oil on a wart localized on the plantar aspect of the right big toe, which had previously been treated with cryotherapy. He developed a severe eczematous eruption on the right foot and the right leg, with subsequent id reactions affecting the right thigh, the contralateral lower limb, the trunk and the upper limbs. The lotion was discontinued, and the dermatitis resolved after topical corticosteroid therapy. Patch testing with the aforementioned lotion 10% pet. and oxidized tea tree oil 5% pet. identified tea tree oil as the culprit agent of the dermatitis. This case report confirms that products made of natural ingredients, often perceived to be harmless, can cause allergic reactions.

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“…Siğil etkeni olarak bilinen insan papilloma virüs (Human papilloma virüs, HPV), epiteliyal hücrelere tropizm gösteren bir DNA virüsüdür [1,2]. Genital HPV enfeksiyonu, dünyada en sık görülen cinsel yolla bulaşan enfeksiyondur ve cinsel aktif erişkinlerin, hayat boyu bir kez HPV ile enfekte olma ihtimali yaklaşık %75'tir [2].…”

Section: Introductionunclassified

“…Genital HPV enfeksiyonu, dünyada en sık görülen cinsel yolla bulaşan enfeksiyondur ve cinsel aktif erişkinlerin, hayat boyu bir kez HPV ile enfekte olma ihtimali yaklaşık %75'tir [2]. Çok sayıda cinsel partner ve erken yaşta cinsel ilişki yaşının erken yaşlarda olması bulaş için risk faktörleri arasındadır [1].…”

Section: Introductionunclassified

Pamukkale University Medical Students’ Level of Knowledge about Importance of Genital Warts

Cenk

EGELİ

TAŞ

et al. 2022

Turkish Journal of Clinics and Laboratory

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Aim: Genital human papillomavirus (HPV) is the most common sexually transmitted infection worldwide. Besides common genital warts, it is also associated with cervical, anal, penile, and oral cancers. It is important to increase the knowledge level of society to prevent the development of cervical cancer, which is an avoidable disease. Therefore, we aimed to evaluate Pamukkale University medical students’ knowledge level about the importance of genital warts and to increase their current knowledge. Material and Methods: A questionnaire composed of 30 closed-ended questions was fulfilled by medical students in the Pamukkale University Faculty of Medicine. The questionnaire was applied by using Google Forms. The questions were asked for evaluating their knowledge on viral transmission, risky sexual behaviors, required measurements, HPV-related diseases, and vaccination in an informative manner (e.g., do you know that HPV can cause warts and/or malignant lesions on the skin, in the oral cavity, anal or vaginal canal and cervix uteri?). After completing the questionnaire, they were asked whether their knowledge was increased or not. Results: The study included 808 medical students. Most of the students (85%) stated that they knew about HPV and genital warts. Seventy percent of them knew the relationship between HPV and cervical cancer, also, 52.2% of the students (21.7% of the male students) knew that anal infections and malignancies were seen more common in men who have sex with men. Seventy-four percent of them had heard about the vaccine, mostly from school or classes (57.5%). Mostly, they approved being vaccinated (79.5%) and educated on sex-related issues in an age-dependent manner (97%) for themselves and their children. After completing the questionnaire, 75.4% out of the students who thought that they had known about HPV (85%) declared that their knowledge increased. Totally 90,1% of all students had increased knowledge at the end of the questionnaire, which was statistically significant (p:0.001). Conclusion: Although the knowledge of the medical students seems to be generally sufficient, it was seen that nearly half of them did not know about the vaccine and the relationship between HPV, cervical cancer, and other malignities. As a result, HPV and related malignant diseases, which are known inadequately even by medical students, continue to threaten public health. Thus, we think that education and vaccination should be encouraged so that individuals can have a chance to protect themselves, their partners, and their children from cervical cancer and other possible malignities.

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Update on human papilloma virus - part I: epidemiology, pathogenesis, and clinical spectrum

Cited by 30 publications

References 48 publications

Viral Manipulation of the Host Epigenome as a Driver of Virus-Induced Oncogenesis

Viral Manipulation of the Host Epigenome as a Driver of Virus-Induced Oncogenesis

Spreading Allergic Contact Dermatitis to Tea Tree Oil in an Over-the-Counter Product Applied on a Wart

Pamukkale University Medical Students’ Level of Knowledge about Importance of Genital Warts

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