An 18-year-old man had recently discovered systemic arterial hypertension, whose etiology was being investigated. He was admitted to the emergency department with adherent white lesions on the tongue and dysgeusia. He had no other known comorbidities, although he complained of nausea, dyspnea at rest, and generalized edema for the previous month. A physical examination revealed adherent and welldemarcated white plaque-like lesions on the tongue surface predominantly under the tongue (Figure 1A), tachycardia (140 bpm), skin pallor, 160/80 mm Hg arterial pressure, signs of pulmonary congestion, and loud pericardial friction rub. Laboratory examinations detected a hemoglobin level of 3.7 g/dl, a total white blood cell count of 12,130/mm 3 , a platelet count of 228,000/mm 3 , a creatinine level of 32.9 mg/dl, a urea level of 479.7 mg/dl, and a potassium level of 6.8 mmol/L. Arterial blood gas analysis showed a pH of 7.23, HCO 3 of 5.3 mmol/L, pCO 2 of 13.1 mm Hg, and lactate of 0.5 mmol/L. Uremia raised suspicion that the oral lesions had been caused by uremic stomatitis.