Pemphigus vegetans developing after Mohs micrographic surgery and cryotherapy

Jetter, Nathan; Cerci, Felipe B.; Pandher, Karan; Krunic, Aleksandar L.

doi:10.1016/j.abd.2020.07.018

Cited by 3 publications

(6 citation statements)

References 2 publications

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“…Reported cases have pemphigus lesions limited to the site of trauma, or generalized. 4,5 Our patient demonstrates that the repetitive needling and angioplasty of the arteriovenous fistula may trigger the development of pemphigus vegetans lesion on this site.…”

Section: Pemphigus Vegetans Overlying An Occlusive Hemodialysis Fistu...mentioning

confidence: 81%

Pemphigus vegetans overlying an occlusive hemodialysis fistula and involving multiple digits

Moe

Wang

2023

The Journal of Dermatology

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Section: Pemphigus Vegetans Overlying An Occlusive Hemodialysis Fistu...mentioning

confidence: 81%

Pemphigus vegetans overlying an occlusive hemodialysis fistula and involving multiple digits

Moe

Wang

2023

The Journal of Dermatology

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“…Jetter et al. described pemphigus vegetans after cryosurgery for actinic keratosis (AKs) at the temple and forehead ( 14 ). In addition, minor procedures such as periodontal procedures, electrosurgery, Mantoux test, or laser surgery could also trigger pemphigus ( 10 , 15 ).…”

Section: Discussionmentioning

confidence: 99%

Involvement of palms and soles in patients with autoimmune bullous diseases: a comparative analysis of a diagnostically relevant localization

Jałowska,

Spałek,

Bowszyc-Dmochowska

et al. 2023

Front. Immunol.

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IntroductionThe involvement of palms and soles is variable among disease entities belonging to autoimmune bullous diseases (AIBD). We present our own clinical-laboratory experience concerning presentations of skin lesions on palms and soles in the pemphigus diseases group, pemphigoid diseases group, epidermolysis bullosa acquisita (EBA), and lichen planus pemphigoides (LPP) and discuss the pertinent literature.MethodsLesions on palms and soles were assessed retrospectively on the basis of just photographic archives from the beginning of 2014 to March 2023. We comparatively evaluated 462 Slavic patients with AIBD.ResultsPalmoplantar involvement was observed in only 21 patients with AIBD (12 females and 9 males). There was no statistically significant difference between palmoplantar involvement in the pemphigus diseases group compared to the pemphigoid diseases group and no statistically significant difference between the pemphigus diseases group compared to the subepithelial AIBD.DiscussionNevertheless, particularly in LPP and EBA, and occasionally in pemphigus diseases and pemphigoid diseases groups of AIBD, localization on palms and soles may be diagnostically important at the clinical level.

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“…Duick et al, presented a case of pemphigus that started in a Mohs surgical wound after an excision of a squamous cell carcinoma (SCC) from a 49-year-old woman [ 41 ]. Jetter et al, described pemphigus vegetans after cryosurgery for actinic keratosis (AKs) at the temple and forehead [ 42 ]. A retrospective study of trauma-induced pemphigus found major surgery procedures (abdominal, chest, and orthopedic) as the most frequent trigger.…”

Section: Discussion Of the Issues Common To The Described Pv Locationsmentioning

confidence: 99%

“…These cytokines may act as facilitators in an already pemphigus-prone skin [ 45 ]. Furthermore, surgical trauma may trigger an epitope-spreading phenomenon [ 42 , 44 ]. Nevertheless, another explanation might be that epidermal injury may expose DSG 1 and 3 and lead to new autoantibody formation in genetically susceptible patients or to activation of pre-existing antibodies already present in low (subclinical) titers [ 42 , 44 ].…”

Section: Discussion Of the Issues Common To The Described Pv Locationsmentioning

confidence: 99%

“…Furthermore, surgical trauma may trigger an epitope-spreading phenomenon [ 42 , 44 ]. Nevertheless, another explanation might be that epidermal injury may expose DSG 1 and 3 and lead to new autoantibody formation in genetically susceptible patients or to activation of pre-existing antibodies already present in low (subclinical) titers [ 42 , 44 ]. An immunocompromised district (ICD), where edema and nerve injury paved the way for a buildup of immunoglobulins and immune cells, is probably associated with the development of pemphigus at postoperative sites [ 46 ].…”

Section: Discussion Of the Issues Common To The Described Pv Locationsmentioning

confidence: 99%

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Sacral Dimple, Conjunctiva, and Nipple as Less Obvious Pemphigus Vulgaris Locations around Natural Body Orifices: A Report of Three Cases

Jałowska

Gornowicz‐Porowska

Bowszyc‐Dmochowska

et al. 2022

JCM

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In this paper, we present our own clinical-laboratory experience concerning three less obvious presentations of pemphigus vulgaris (PV) and discuss the pertinent literature. The involvement of the sacral dimple reported here for the first time, as well as the nipple and the eyes, could initially be misleading clinically. These less stereotypical localizations may occur due to the transition of different epithelia, each with varying levels of cadherin (desmoglein, desmocollin) and thus altered sensitivity to mechanical stress. The role of dermatologists who have experience in treating autoimmune blistering dermatoses is fundamental for identifying promptly the initial and exacerbating PV lesions in such unusual locations.

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Pemphigus vegetans developing after Mohs micrographic surgery and cryotherapy

Cited by 3 publications

References 2 publications

Pemphigus vegetans overlying an occlusive hemodialysis fistula and involving multiple digits

Pemphigus vegetans overlying an occlusive hemodialysis fistula and involving multiple digits

Involvement of palms and soles in patients with autoimmune bullous diseases: a comparative analysis of a diagnostically relevant localization

Sacral Dimple, Conjunctiva, and Nipple as Less Obvious Pemphigus Vulgaris Locations around Natural Body Orifices: A Report of Three Cases

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