Clinical evolution of neural function in a series of leprosy neuropathy cases after ulnar neurolysis

Barroso‐Freitas, Juliana; Ribas, Pedro Arthur da Rocha; Rebello, Paula Frassinetti Bessa; Pennini, Silmara Navarro

doi:10.1016/j.abd.2020.07.015

Cited by 1 publication

(2 citation statements)

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“…A study conducted in Manaus, Brazil, showed that simultaneous administration of clinical treatment for leprosy neuritis improved the effectiveness of treatment for neuritis. This combined treatment contributed to the prevention of relapse and the development of chronic conditions, reducing the risk of progression to physical disability, improving sensory and motor function, and avoiding prolonged corticosteroid therapy and its associated consequences 6 . Individuals who underwent neurolysis showed partial regeneration of preoperative deformities 7,13,14,17 .…”

Section: Discussionmentioning

confidence: 99%

“…Among the guidelines for treating the complications of leprosy neuritis, pharmacological treatment with corticosteroids is recommended to control potential complications, such as pain, permanent neural damage, and inflammatory processes [2][3][4] . In cases of therapeutic failure or absolute contraindications, neurolysis, a medical surgical technique, may be indicated as a possible treatment 5,6 .…”

Section: Introductionmentioning

confidence: 99%

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Effectiveness of neurolysis as a treatment for complications of leprosy neuritis: a systematic review

Gonçalves

Fuentealba-Torres

Silva

et al. 2023

Rev. Soc. Bras. Med. Trop.

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Background: Complications of leprosy neuritis are considered serious and apparent, with the potential to disable and/or limit individuals. These complications affect not only a patient's physical functioning, but also their family and social lives, while directly impacting the ability to work and/or maintain financial independence, subsequently interfering with their overall quality of life. The present review, therefore, aimed to analyze the effectiveness of neurolysis as an alternative treatment for the complications associated with leprosy neuritis. Methods:The present review was performed based on the Joanna Briggs Institute methodology, in an effort to answer the following research question: what is the effectiveness of neurolysis as a treatment for leprosy neuritis complications? This research question was defined using the patient-intervention-outcome (PIO) framework, where leprosy represents 'P', neurolysis for 'I', and neuropathic pain/ motor function/sensorial function/physical disability/quality of life for 'O'. Randomized and non-randomized clinical trials and prospective observational cohort studies were included in the present review, with no time or date restrictions. Results:The present review included 1 randomized clinical trial and 10 prospective studies, published between 1976 and 2020. All of the outcomes showed improvement, with relief from neuropathic pain being the primary finding. Conclusions:The evidence obtained in the present review suggested that neurolysis is an effective alternative for the treatment of physical disabilities, the recovery of sensory and motor function, the restoration of quality of life, and neuropathic pain relief.

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Section: Discussionmentioning

confidence: 99%