Expression of OPN3 in fibroblasts, melanocytes, and keratinocytes of skin with facial melasma in comparison with unaffected adjacent skin

Espósito, Ana Cláudia Cavalcante; Souza, Nathália Pereira de; Miot, Luciane Donida Bartoli; Miot, Hélio Amante

doi:10.1016/j.abd.2020.05.016

Cited by 4 publications

(2 citation statements)

References 8 publications

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“…20 Nevertheless, OPN3 receptors were not differentially expressed in keratinocytes, melanocytes, or fibroblasts between facial melasma and the healthy adjacent skin. 21 Visible light-induced hyperpigmentation in darker skin types was deeper and longer-lasting over a two-week period compared to UVA1. 22 In addition, compared with UVB irradiation, blue-violet light (415 nm) induced significantly evident hyperpigmentation in a dose-dependent manner.…”

Section: Ultraviolet and Visible Light Exposurementioning

confidence: 92%

New Mechanistic Insights of Melasma

Liu¹,

Chen²,

Xia³

2023

CCID

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Melasma is a common acquired disorder of pigmentation that negatively impacts quality of life. Present treatments show poor therapeutic effect with frequent recurrence. This in large part is due to the currently limited understanding of the disease's etiology. It is urgent to elucidate the pathogenesis of melasma to further the discovery of new therapeutic strategies. Recent studies show that melasma is triggered or aggravated by a variety of factors, including genetic susceptibility, ultraviolet radiation, and sex hormone dysregulation. Ultraviolet B radiation upregulates the expression of several melanocyte-specific genes and stimulates the release of key factors that participate in the synthesis of melanin. There is a significant increase in melanin in both the epidermal and dermal layers of affected skin, possibly due to abnormalities in crosstalk between the melanocytes and other cells. Melanogenesis is regulated through various signaling networks including the Wnt/β-catenin, PI3K/Akt, cAMP/PKA, and SCF/c-kit-mediated signaling pathways. In addition, inflammatory mediators, oxidative stress, neuroactive molecules, sebocytes, etc, have also been proved to be related to the pathogenesis of melasma. This review provides a comprehensive update on the current understanding of the pathogenesis of melasma.

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Section: Ultraviolet and Visible Light Exposurementioning

confidence: 92%

New Mechanistic Insights of Melasma

Liu¹,

Chen²,

Xia³

2023

CCID

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“…Pigmentation is found only in darker phototypes (III-VI) after high doses of VL exposure, and only shorter wavelengths (420-470 nm, blue and violet) can induce pigmentation through the activation of opsin 3 (OPN3) receptors in melanocytes [31]. While OPN3 is not overexpressed in skin with facial melasma compared with adjacent skin, use of tinted sunscreens (with iron oxides), which block short VL wavelengths, enhances the depigmenting effect of hydroquinone and hinders melasma pigmentation in summer [32,33].…”

Section: Solar Radiationmentioning

confidence: 99%

Update on Melasma—Part I: Pathogenesis

Espósito¹,

Cassiano

Silva³

et al. 2022

Dermatol Ther (Heidelb)

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Melasma is a multifactorial dyschromia that results from exposure to external factors (such as solar radiation) and hormonal factors (such as sex hormones and pregnancy), as well as skin inflammation (such as contact dermatitis and esthetic procedures), in genetically predisposed individuals. Beyond hyperfunctional melanocytes, skin with melasma exhibits a series of structural and functional alterations in the epidermis, basement membrane, and upper dermis that interact to elicit and sustain a focal hypermelanogenic phenotype. Evolution in the knowledge of the genetic basis of melasma and the cutaneous response to solar radiation, as well as the roles of endocrine factors, antioxidant system, endothelium proliferation, fibroblast senescence, mast cell degranulation, autophagy deficits of the melanocyte, and the paracrine regulation of melanogenesis, will lead to the development of new treatments and preventive strategies. This review presents current knowledge on these aspects of the pathogenesis of melasma and discusses the effects of specific treatments and future research on these issues.

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Non-image-forming functional roles of OPN3, OPN4 and OPN5 photopigments

Karthikeyan

Gunhaga

2023

Journal of Photochemistry and Photobiology

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Expression of OPN3 in fibroblasts, melanocytes, and keratinocytes of skin with facial melasma in comparison with unaffected adjacent skin

Cited by 4 publications

References 8 publications

New Mechanistic Insights of Melasma

New Mechanistic Insights of Melasma

Update on Melasma—Part I: Pathogenesis

Non-image-forming functional roles of OPN3, OPN4 and OPN5 photopigments

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