Depressive symptoms before and during treatment of acne with isotretinoin and its correlations: a prospective study

Luvizotto, Priscilla Pereira; Schmitt, Juliano Vilaverde

doi:10.1016/j.abd.2020.04.008

Cited by 4 publications

(2 citation statements)

References 4 publications

(4 reference statements)

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“…One patient attempted suicide and four (3.4%) had an increase on the BDI to 10 or greater, indicating the development of mild depression. Other studies showed similar improvement in depression using the BDI or similar instruments, including reports from Bozdağ et al (2009) with the BDI in 50 patients, Ergun et al (2012) with the BDI in 48 patients, Nevoralová and Dvořáková (2013) with 100 patients, Schmitt and Luvizotto (2020) with the BDI in 42 patients, Gnanaraj et al (2015) et al with the HDRS in 150 patients, Rubio-Garcíam et al (2015) with the BDI in 22 patients, and Marron et al (2013) with the HADS in 346 patients. Ergun et al (2012) l had five patients develop depression on isotretinoin although overall mood scores improved.…”

Section: Isotretinoin Treatment Studies In Acne Patientsmentioning

confidence: 75%

Isotretinoin and neuropsychiatric side effects: Continued vigilance is needed

Bremner

2021

Journal of Affective Disorders Reports

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Section: Isotretinoin Treatment Studies In Acne Patientsmentioning

confidence: 75%

Isotretinoin and neuropsychiatric side effects: Continued vigilance is needed

Bremner

2021

Journal of Affective Disorders Reports

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“…Previously, treatment of acne with isotretinoin has been met with resistance due to fear of psychiatric side effects. 37 This fear has now largely been put to rest, as acne patients treated with isotretinoin do not appear to have an increased risk of depression. 38,39 Our results confirm that patients with untreated acne have a numerical trend for increased risk of depression.…”

Section: Discussionmentioning

confidence: 99%

The Social and Psychological Impact of Acne Treatment: A Cross-Sectional Study of Blood Donors

et al. 2022

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Background Acne in adolescence and adulthood is believed to have a long-term impact on socioeconomic status (SES) and health-related quality-of-life (HRQoL) in adults. Objective To estimate the cross-sectional prevalence of medically treated (MedTreAc) and untreated acne (UnTreAc) and to characterize its long-term impact in adults. Methods A nationwide cross-sectional study on 17 428 blood donors aged 18-35 was performed. Associations among acne and HRQoL, depressive symptoms, total income, and SES were investigated via linear/logistic/multinomial logistic regression analyses adjusted for relevant covariables. HRQoL was measured by the Short Form-12, and depressive symptoms by the Major Depression Inventory. The data were self-reported. Results Of the participants, 3591 (20.6%) and 1354 (7.8%) identified as the MedTreAc and UnTreAc phenotype, respectively. Neither phenotype was associated with a long-term impact on total income, but the MedTreAc group was associated with being an apprentice/student (OR = 1.26; 95% CI: 1.12, 1.42; P = 1.3×10-4) or high skill-level employee (OR = 1.22, 95% CI: 1.07; 1.39, P = .0023), while self-employment was more common for those with UnTreAc (OR = 1.53; 95% CI: 1.12, 2.06, P = .0061). Additionally, the UnTreAc group was associated with a lower mental HRQoL (SF-12 mental component summary score −1.05, 95% CI: −1.56, −0.54; P = 1.4×10-9) and increased odds ratio of depressive symptoms (OR = 1.44; 95% CI: 1.00, 2.02, P = .046). Conclusion In this population of blood donors, the cumulative prevalence of MedTreAc and UnTreAc were 20.6% and 7.8%, respectively. Untreated acne had a long-term impact on psychosocial well-being in adulthood. It was associated with lower mental HRQoL and higher occurrence of depressive symptoms. Acne was not associated with a lower salary or SES.

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Isotretinoin for acne vulgaris – an update on adverse effects and laboratory monitoring

Fallah

Rademaker

2022

Journal of Dermatological Treatment

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Depressive symptoms before and during treatment of acne with isotretinoin and its correlations: a prospective study

Cited by 4 publications

References 4 publications

Isotretinoin and neuropsychiatric side effects: Continued vigilance is needed

Isotretinoin and neuropsychiatric side effects: Continued vigilance is needed

The Social and Psychological Impact of Acne Treatment: A Cross-Sectional Study of Blood Donors

Isotretinoin for acne vulgaris – an update on adverse effects and laboratory monitoring

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