Malignant melanoma after treatment for Merkel cell carcinoma

Ishikawa, Masato; Yamamoto, Toshiyuki

doi:10.1016/j.abd.2020.02.013

Cited by 3 publications

(2 citation statements)

References 4 publications

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“…There have been reports describing the development of malignant melanoma following the treatment of MCC, but reports documenting the development of MCC following the excision of malignant melanoma are scarce. 9 Interestingly, there has been a report of a patient who was incidentally found to have both metastatic MCC and metastatic melanoma in a single sentinel lymph node following wide local excision of Merkel cell carcinoma. 10 Regardless, the development of MCC as a second cancer to malignant melanoma is underreported.…”

Section: Discussionmentioning

confidence: 99%

Development of metastatic Merkel cell carcinoma following the excision of same‐sided recurrent auricular melanoma

Cartwright

Snyder²,

Moreno³

2022

Clinical Case Reports

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Merkel cell carcinoma (MCC) is a rare neuroendocrine malignancy of the skin that is highly aggressive and often metastasizes early. MCC is diagnosed based on histopathological findings and is most commonly treated with surgical resection, which may be accompanied by chemotherapy and/or radiation. This report describes a 55-year-old male patient with the history of recurrent malignant melanoma of the right pinna and subsequent excision. Three years following the excision of melanoma, he presented with a lesion to the right forehead as well as a right-sided neck mass that were found to be metastatic Merkel cell carcinoma.

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Section: Discussionmentioning

confidence: 99%

Development of metastatic Merkel cell carcinoma following the excision of same‐sided recurrent auricular melanoma

Cartwright

Snyder²,

Moreno³

2022

Clinical Case Reports

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“…Saxena et al revealed an increased risk of second primary cancer following the diagnosis of MCC, with cutaneous malignant melanoma being the most prevalent cancer to follow MCC (standardized incidence ratio (of 3.09; 95% confidence interval, 2.02-4.73) [36]. Better understanding of the etiology of the second malignancy in MCC patients will help in better assessment of the disease prognosis and optimization of treatment, follow-up and surveillance posttreatment [37,38].…”

Section: Immunotherapiesmentioning

confidence: 99%

Updates on the diagnosis, current and future therapeutic options in Merkel-cell carcinoma

2021

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Merkel-cell carcinoma (MCC) is a rare and extremely aggressive nonmelanocytic cutaneous neuroendocrine carcinoma. Historically, it has been associated with limited therapy options and poor prognosis. While its incidence has been rising over the last two decades, recent discoveries and a better understanding of its pathogenesis, viral association and immunologic features have allowed for the emergence of new therapies. Surgical excision with or without radiotherapy remains the first-line therapy for primary lesions without evidence of metastatic disease. The majority of MCC cases are regrettably diagnosed at advanced stages and oftentimes require systemic therapy. There have been several significant advances in the treatment of MCC in the last decade. Among these have been the development of immune checkpoint inhibitors targeting the programmed death protein-1 (PD-1)/programmed death ligand-1 (PDL-1). Despite recent success of immunotherapy, nearly 50% of patients diagnosed with MCC still succumb to the disease. Fortunately, there has been a number of new targeted therapies that hold great promise. Among them are phosphatidylinositide-3kinase (Pl3K) inhibitors, adoptive T-cell immunotherapy, activated NK-92 cells infusions and therapeutic vaccines. Additional emerging therapeutic targets include cellular ubiquitin-specific processing protease 7 (Usp7) that restricts viral replication and IFN genes (STING), activation of which promotes an antitumor inflammatory response.

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Carcinoma de Merkel primario de la mama en un hombre con injerto cutáneo: reporte de caso

et al. 2022

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Introducción. El carcinoma de células de Merkel (CCM) es un cáncer neuroendocrino de la piel, agresivo, muy poco frecuente que, por lo general, aparece como un nódulo en la cara, cabeza o cuello. El CCM ocurre principalmente en adultos mayores. Presentación del caso. Hombre de 85 años, blanco, que asistió al Servicio de Mastología del Instituto Nacional de Oncología y Radiobiología (INOR), en La Habana, Cuba, por aumento de volumen, cambio de color y temperatura en la mama derecha. El paciente había sufrido trauma térmico en el hemitórax derecho 18 años antes de la consulta, el cual fue tratado mediante injerto cutáneo del muslo. En los estudios de imagen (ultrasonido, mamografía, resonancia magnética y tomografía computarizada) se observó un nódulo con características imagenológicas sugestivas de malignidad. El diagnóstico de CCM se confirmó mediante biopsia por punción con aguja gruesa, donde se reportó positividad de marcadores CD-56, CK-7 y Ki- 67. Conclusiones. Característicamente, el CCM se presenta como nódulos cutáneos firmes de rápido crecimiento en las áreas expuestas al sol, a diferencia del presente caso, en el que la lesión apareció en la piel injertada en el hemitórax derecho. Reconocer hallazgos imagenológicos sugestivos de esta neoplasia es de gran importancia para el diagnóstico en zonas inusuales del cuerpo como la mama.

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Malignant melanoma after treatment for Merkel cell carcinoma

Cited by 3 publications

References 4 publications

Development of metastatic Merkel cell carcinoma following the excision of same‐sided recurrent auricular melanoma

Development of metastatic Merkel cell carcinoma following the excision of same‐sided recurrent auricular melanoma

Updates on the diagnosis, current and future therapeutic options in Merkel-cell carcinoma

Carcinoma de Merkel primario de la mama en un hombre con injerto cutáneo: reporte de caso

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