Ischemia-modified albumin as a possible marker of oxidative stress in patients with telogen effluvium

Savcı, Ünsal; Şenel, Engin; Öztekin, Aynure; Sungur, Mustafa; Erel, Özcan; Neşeli̇oğlu, Salim

doi:10.1016/j.abd.2020.01.005

Cited by 12 publications

(5 citation statements)

References 20 publications

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“…Oxidative stress has been suggested in the pathogenesis of AA, AGA, and TE . Antioxidants—eg, selenium, carotenoids, and vitamins A, C, and E—are commonly included in supplements.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of the Safety and Effectiveness of Nutritional Supplements for Treating Hair Loss

et al. 2023

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ImportanceDespite the widespread use of nutritional supplements and dietary interventions for treating hair loss, the safety and effectiveness of available products remain unclear.ObjectiveTo evaluate and compile the findings of all dietary and nutritional interventions for treatment of hair loss among individuals without a known baseline nutritional deficiency.Evidence ReviewThe MEDLINE, Embase, and CINAHL databases were searched from inception through October 20, 2021, to identify articles written in English with original findings from investigations of dietary and nutritional interventions in individuals with alopecia or hair loss without a known baseline nutritional deficiency. Quality was assessed with Oxford Centre for Evidence Based Medicine criteria. Outcomes of interest were disease course, both objectively and subjectively measured. Data were evaluated from January 3 to 11, 2022.FindingsThe database searches yielded 6347 citations to which 11 articles from reference lists were added. Of this total, 30 articles were included: 17 randomized clinical trials (RCTs), 11 clinical studies (non-RCT), and 2 case series studies. No diet-based interventional studies met inclusion criteria. Studies of nutritional interventions with the highest-quality evidence showed the potential benefit of Viviscal, Nourkrin, Nutrafol, Lamdapil, Pantogar, capsaicin and isoflavone, omegas 3 and 6 with antioxidants, apple nutraceutical, total glucosides of paeony and compound glycyrrhizin tablets, zinc, tocotrienol, and pumpkin seed oil. Kimchi and cheonggukjang, vitamin D3, and Forti5 had low-quality evidence for disease course improvement. Adverse effects were rare and mild for all the therapies evaluated.Conclusions and RelevanceThe findings of this systematic review should be interpreted in the context of each study’s design; however, this work suggests a potential role for nutritional supplements in the treatment of hair loss. Physicians should engage in shared decision-making by covering the potential risks and benefits of these treatments with patients experiencing hair loss. Future research should focus on larger RCTs with active comparators.

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“…Oxidative stress has been suggested in the pathogenesis of AA, AGA, and TE . Antioxidants—eg, selenium, carotenoids, and vitamins A, C, and E—are commonly included in supplements.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of the Safety and Effectiveness of Nutritional Supplements for Treating Hair Loss

et al. 2023

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“…It is well known that the oxidative stress environment of the scalp results in oxidatively modified proteins on the maturing hair fibre and surrounding follicular tissue [12]. It has also been shown that oxidative stress markers correlate with conditions of hair loss [47].…”

Section: Discussionmentioning

confidence: 99%

Scalp application of antioxidants improves scalp condition and reduces hair shedding in a 24‐week randomized, double‐blind, placebo‐controlled clinical trial

Davis

Piliang

Bergfeld

et al. 2021

Intern J of Cosmetic Sci

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Increasing hair fullness is a global unmet need for many men and women. An approach to the problem is to decrease hair fall or shedding by reducing scalp stratum corneum oxidation and barrier damage to increase hair retention. This study evaluated a combination of functional antioxidants and barrier-enhancing cosmetic ingredients to improve scalp condition thereby enabling stronger hair anchorage and longer retention.Methods: Male and female subjects with normal scalp condition and self-perceived hair thinning participated in a 24-week, double-blind, placebo-controlled, randomized clinical study assessing either a regimen of treatment shampoo and leaveon treatment containing functional antioxidant and barrier-enhancing agents or an identical placebo chassis shampoo control. The functional ingredients were piroctone olamine, zinc pyrithione, zinc carbonate, niacinamide, panthenol and caffeine. At baseline and after 8, 16 and 24 weeks of product use, several measurements were taken: hair shedding, total hair count (by phototrichogram), hair samples, TEWL and evaluation of biomarkers of scalp and hair conditions. Subjects also completed self-assessment questionnaires.Results: Statistically significant effects for functional ingredient-containing treatment regimen versus a placebo control shampoo formulation were observed for reduced hair shedding, increased total hair count, reduced TEWL and improvement in scalp biomarker values. Subjects also noticed these improvements assessed via self-assessment questionnaires.Conclusions: These results establish that the use of functional antioxidant and barrier-enhancing agents to further improve scalp condition can enable a reduction in hair shedding and thus an increase in perceived hair fullness. The underlying improvements in scalp condition suggest the hair benefits were achieved as a result of improved scalp skin barrier and scalp condition leading to a viable preventative approach for hair thinning.

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“…Few studies have also reported high serum IMA levels in some dermatological diseases associated with OS, such as psoriasis [8], vitiligo[38], Behçet's disease [39], AA [12], and telogen e uvium [40]. In another study, it was reported that increased IMA levels in patients with AA might be associated with the antioxidant/oxidant imbalance and cardiovascular disease risk [19].…”

Section: Discussionmentioning

confidence: 99%

Association of oxidative stress in mild patchy alopecia areata: a case- control study

Kakşi,

Ülfer,

Çakıter

et al. 2023

Preprint

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Background Alopecia areata (AA) is a chronic immune-mediated disease characterized by sudden-onset, sharply circumscribed alopecic patches that can occur in any part of the body, mostly on the scalp. Its etiology has not yet been fully clarified. Recently, increasing data regarding the relationship between oxidative stress and AA are available in the literature. Objectives To evaluate the effect of oxidative stress with ischemia-associated albumin (IMA) and conventional methods together with total oxidant state (TOS), total antioxidant state (TAS) and oxidative stress index (OSI) in patients with new-onset mild AA. Methods The study was conducted as a single-center, prospective, case-control study and included 36 patients with AA and 34 healthy volunteers. Serum TAS, TOS, OSI and IMA levels were compared between the two groups. Results The TOS and OSI levels were found to be significantly higher and the TAS level was significantly lower in the AA group. Although the IMA level was higher in the AA group, it did not significantly differ from the control group. Conclusions This study supports the presence of a relationship between oxidative stress and AA. Antioxidant defense mechanisms may be delayed to compensate for the high oxidant levels in mild acute AA. Oxidative damage can also be caused by non-ischemic pathways, and IMA levels may become more pronounced in more chronic and severe cases. We consider that there is a need to investigate individual oxidative causes in larger and different subgroup populations of AA and re-evaluate related markers after antioxidant treatment.

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Ischemia-modified albumin as a possible marker of oxidative stress in patients with telogen effluvium

Cited by 12 publications

References 20 publications

Evaluation of the Safety and Effectiveness of Nutritional Supplements for Treating Hair Loss

Evaluation of the Safety and Effectiveness of Nutritional Supplements for Treating Hair Loss

Scalp application of antioxidants improves scalp condition and reduces hair shedding in a 24‐week randomized, double‐blind, placebo‐controlled clinical trial

Association of oxidative stress in mild patchy alopecia areata: a case- control study

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