Update on vasculitis: an overview and dermatological clues for clinical and histopathological diagnosis – part I

Morita, Tharnara Cristiane Alves Batista; Trés, Gabriela Franco Sturzeneker; Criado, Roberta Fachini Jardim; Sotto, Mírian Nacagami; Criado, Paulo Ricardo

doi:10.1016/j.abd.2020.01.003

Cited by 29 publications

(30 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ANA, ANCA and serum complement levels are laboratory tests that help the physician in knowing the pathophysiology and diagnosis. [19] The complement system is a major component of innate immunity and an effector arm of humoral immune system. It also serves as a mechanism to identify and clear injured tissue and cellular debris.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Vasculitis-Associated Auto-antibodies and Complement Levels in patients with COVID-19 Infection

Mobini

Ghasemian

Larijani

et al. 2020

Preprint

View full text Add to dashboard Cite

Introduction / objectives: The cause of coronavirus disease 2019 (COVID-19) is severe acute respiratory syndrome 2 (SARS-CoV-2). There are evidences of involvement of immune system in pathogenesis of this disease. We investigated the presence of various vasculitis-associated auto-antibodies and complement levels in a series of patients with COVID-19 infection admitted to our hospital.Methods: Forty patients with severe or critical type of COVID 19 were evaluated for symptoms, signs and laboratory tests of vasculitis syndromes including rheumatoid factor (RF), anti-nuclear antibody (ANA), anti dsDNA, c and p anti-neutrophilic cytoplasmic antibody (c ANCA and p ANCA) and complement levels. Descriptive statistics methods were used to describe the clinical / laboratory findings.Results: Forty patients with severe to critical illness were enrolled in the study. The mean age of the patients was 48.5 ± 9.8 years. All patients had pulmonary involvement in lung CT scan. Lymphopenia in 19 (47.5%), raised creatinine in 8(20%) and hyperbilirubinemia in 19(47.5%) of patients were seen. Vasculitis laboratory test results included: RF in 2 patients, ANA in 3 patients and ANCA in one patient. 17(42.5%) of patients had hypocomplementemia in one or more complement tests. Of the four patients who were expired, three had a decrease in complement.Conclusion: In 17 of patients (42.5%) we detected low complement levels. A decrease in complement levels may predict a critical state of the disease. Therefore, measuring its levels may be helpful in making earlier decisions to initiate disease-suppressing treatments, including corticosteroids and IVIG.

show abstract

Section: Discussionmentioning

confidence: 99%

“…We encountered limitations in the study. First: this study was performed as a pilot on these patients and according our knowledge, evaluation of vasculitis tests and complement levels in COVID- 19 have not yet been published. Therefore, we did not have any previous study to estimate the number of samples based on them.…”

Section: Discussionmentioning

confidence: 99%

Vasculitis-Associated Auto-antibodies and Complement Levels in patients with COVID-19 Infection

Mobini

Ghasemian

Larijani

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…ANA, ANCA, and serum complement levels are laboratory tests that help the physician in understanding the pathophysiology and making accurate diagnosis. [ 23 ] In this study, we did not find any classic vasculitis syndrome which might be due to small sample size, but the variety of symptoms in patients with COVID-19 can be similar and mimic the syndromes of vasculitis.…”

Section: Discussionmentioning

confidence: 56%

Immunologic markers, vasculitis-associated autoantibodies, and complement levels in patients with COVID-19

et al. 2021

View full text Add to dashboard Cite

Background: The cause of coronavirus disease 2019 (COVID-19) is a virus which can lead to severe acute respiratory syndrome-CoV-2 (SARS-COV-2). There are evidences of involvement of immune system in pathogenesis of this disease. We investigated the presence of various vasculitis-associated autoantibodies and complement levels in patients with COVID-19. Materials and Methods: Patients with severe or critical type of COVID-19 were evaluated for symptoms, signs, and laboratory tests of vasculitis syndromes including rheumatoid factor (RF), antinuclear antibody (ANA), anti-double-stranded DNA, c and p anti-neutrophilic cytoplasmic antibody (c ANCA and P ANCA), and complement levels. Results: The study was performed in forty patients with severe or critical illness. The mean age of the participants was 48.5 ± 9.8 years. All patients had pulmonary involvement in lung computed tomography scans. Vasculitis laboratory test results included RF in two patients, ANA in three patients, and ANCA in one patient. Seventeen (42.5%) patients had hypocomplementemia in one or more complement tests. Four patients expired, of whom three had a decrease in complement level. Conclusion: Decrease in complement levels may predict a critical state of COVID-19 disease. Therefore, measuring its levels may be of great benefit in making earlier decisions to initiate disease-suppressing treatments including corticosteroids.

show abstract

“…Vessels caliber in the reticular dermis, ranges from 50 to 150 μm. 19 The border between papillary and reticular dermis hosts a superficial plexus that supplies the dermal papillae through a candelabra-like capillary system. 8,20 This superficial plexus is located 1-1.5 mm below the skin surface and consists of vessels less than 50 μm in caliber.…”

Section: Discussionmentioning

confidence: 99%

“…The two horizontal plexuses are connected by direct, vertical, arborizing channels. 19 In the US assessment of vascularization of breast and thyroid nodules, for example, the difficulty resides in the small caliber of the vessels and in the slow flow of the blood inside them. For the skin assessment, there are two additional obstacles.…”

Section: Discussionmentioning

confidence: 99%

Seeing the unseen with superb microvascular imaging: Ultrasound depiction of normal dermis vessels

Corvino

Varelli

Cocco

et al. 2021

J of Clinical Ultrasound

View full text Add to dashboard Cite

Purpose: Current color-and power-Doppler techniques cannot demonstrate vascularization of the dermis. Aim of this prospective study was to investigate whether the new superb vascular imaging (SMI) technique improves the ultrasound (US) depiction of dermis vessels in healthy volunteers. SMI was compared side-byside to conventional power-Doppler (PD) imaging.Methods: Thirty adult subjects (18 men and 12 women, mean age 45 years old) were evaluated with US at level of five body areas: forehead, forearm, palm, buttock, and thigh. The vascular index (VI) was employed to objectively quantify the difference between SMI and PD imaging in terms of dermis flow amount.Results: Forehead VI was higher for SMI than for PD in 93% of cases, forearm VI was higher for SMI than for PD in 97% of cases, palm VI was higher for SMI than for PD in 87% of cases, buttock VI was higher for SMI than for PD in 100% of cases, thigh VI was higher for SMI than for PD in 100% of cases. SMI-detected vascular signals in 100% of the body areas. PD failed to show any flow signals from the forehead in 23% of cases, forearm in 37% of cases, palm in 33% of cases, buttock in 47% of cases, and thigh in 50% of cases. Conclusion: SMI can demonstrate normal dermis vascularization whereas conven-tional PD cannot. SMI is a sensitive and promising technique in the study of dermis abnormalities, particularly when quantifying the disease activity is important.dermal vessels, dermatology ultrasound, Doppler ultrasound (US), power-Doppler (PD), superb microvascular imaging (SMI) | INTRODUCTIONThe skin is composed by the epidermis and the dermis, the latter consisting for 70% of connective tissue. [1][2][3] Dermis thickness varies in the different body areas, decreasing with aging. [1][2][3][4] The dermis has an intense vascularization, particularly in its deeper aspect. [1][2][3] This vascular network serves a number of vital functions such as nutritional support for tissues and homeostasis. 5 However, dermis vessels are usually not Abbreviations: PD, power Doppler; SMI, superb microvascular imaging; US, ultrasound; VI, vascular index.We confirm that this work is original and has not been published elsewhere nor is it currently under consideration for publication elsewhere.

show abstract

Update on vasculitis: an overview and dermatological clues for clinical and histopathological diagnosis – part I

Cited by 29 publications

References 36 publications

Vasculitis-Associated Auto-antibodies and Complement Levels in patients with COVID-19 Infection

Vasculitis-Associated Auto-antibodies and Complement Levels in patients with COVID-19 Infection

Immunologic markers, vasculitis-associated autoantibodies, and complement levels in patients with COVID-19

Seeing the unseen with superb microvascular imaging: Ultrasound depiction of normal dermis vessels

Contact Info

Product

Resources

About