Healing effects of natural latex serum 1% from Hevea brasiliensis in an experimental skin abrasion wound model

Leite, Marcel Nani; Caetano, Guilherme Ferreira; Andrade, Thiago Antônio Moretti de; Frade, Marco Andrey Cipriani

doi:10.1016/j.abd.2019.12.003

Cited by 10 publications

(10 citation statements)

References 35 publications

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“…In addition, Leite et al. [ 16 ] used the same animal model to treat excoriations with latex and showed similar results regarding re-epithelialization and the delay when using antiseptic and saline.…”

Section: Discussionmentioning

confidence: 97%

“…First intention wounds, including abrasions, usually occur with domestic accidents and aesthetic procedures that involve abrasion. For these wounds, treatments are carried out to reduce pain and to keep the wound moist [ 16 , 18 , 19 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

“…The animals were randomly divided into three groups, with 24 rats each and their injured areas were treated topically with (sufficient amount to cover the lesion), once a day, for 14 days with 0.2% hyaluronic acid cream (HA), 10 mg/mL chlorhexidine digluconate as a positive control (CD) or 0.9% sodium chloride solution (saline) (S). No occlusive dressing was used [ 16 ].…”

Section: Methodsmentioning

confidence: 99%

“…The abrasions were photographed on days 2, 7, 10 and 14 and subsequently analyzed by ImageJ software to calculate the abrasion healing rate (AHR), calculated by the formula [(initial area - final area)/initial area] as described and performed by Leite et al. [ 16 ].…”

Section: Methodsmentioning

confidence: 99%

“…Subsequently, a line was drawn from the granular layer of the epidermis until the transition with the dermis, to measure the epidermis thickness and crust thickness. At the end of the tracing, the software provided the distance in micrometers [ 16 ].…”

Section: Methodsmentioning

confidence: 99%

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Efficacy of 0.2% hyaluronic acid in the healing of skin abrasions in rats

Leite

Frade

2021

Heliyon

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Acute injuries, such as surgical and traumatic, heal normally in an organized and rapid manner. Studies point to the healing activity of hyaluronic acid in all phases of healing. The aim was to evaluate the effectiveness of hyaluronic acid in skin abrasions on the dorsum of rats to compare to usual products on the market. Seventy-two Wistar rats were subjected to excoriation of approximately 2.0 cm 2 on the back by dermabrasion. According to the treatment, 3 groups were established: saline, chlorhexidine digluconate and 0.2% hyaluronic acid for 14 days. Animals were photographed on the 2 nd , 7 th , 10 th and 14 th postinjury days, and the index of healing of the abrasions was calculated. Biochemically, myeloperoxidase measurements of skin biopsies in addition to histological studies to assess the crust and epidermal layers were performed. The group treated with hyaluronic acid showed better re-epithelialization from the other groups (p < 0.05) on the 7 th and 10 th days. For the thickness of the crust, the hyaluronic acid group presented thinner crust than other groups on the 10 th and 14 th days (p < 0.05), but in the epidermis, no difference was observed between the groups studied. All groups showed an increase in myeloperoxidase enzyme on the 2 nd day, but a decreasing on the 7 th day. On the 10 th day, there was a difference in the hyaluronic acid group compared to the other groups (p < 0.05). The application of 0.2% hyaluronic acid significantly accelerated the re-epithelialization of skin abrasions compared to saline and chlorhexidine digluconate.

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Section: Discussionmentioning

confidence: 97%