Melanoma risk factors in a Latin American population

Nova, John; Sánchez-Vanegas, Guillermo; Gamboa, Mauricio Andión; Gil‐Quiñones, Sebastian Ramiro

doi:10.1016/j.abd.2019.11.009

Cited by 6 publications

(4 citation statements)

References 4 publications

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“…However, it seems that the incidence has increased in the last years in line with world data. The geographic diversity of the region, the presence of native inhabitants and the European and African descendants conform a heterogeneous feature that sometimes complicates obtaining solid conclusions [10,11]. The age-standardised incidence rates of CM per 100,000 people was established nearly 3-4.5 with a median age of 60 years, while mortality incidence was found to be 0.6-1.2/100,000 [12,13].…”

Section: Discussionmentioning

confidence: 99%

Role of sentinel lymph node biopsy for cutaneous melanoma in elderly patients: preliminary results in a Latin-American population

Featherston¹,

Nardi²,

Tomé³

et al. 2021

ecancer

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Introduction:In melanoma, lymph node status constitutes the most important prognostic factor among patients with locoregional disease. It has been postulated that elderly patients present less metastatic involvement in sentinel lymph node (SLN). Our objective was to analyse the results and evolution of patients ≥ 70 years-old with cutaneous melanoma in whom sentinel lymph node biopsy (SLNB) was carried out.Methods: Retrospective analysis of 194 patients with primary CM who had a SLNB between 2005 and 2020 was included. Demographic and tumour data, SLN status, recurrence rate, morbidity and evolution were evaluated. Patients were divided into two groups according to age: Group 1 (<70 years old) and Group 2 (≥70 years old).Results: One hundred and fifty patients were included in Group 1 and 44 patients in Group 2. Median Breslow thickness was 1.7 mm in Group 1 and of 2 mm in Group 2 (p = 0.015).Forty-seven patients had positive SLNB; 38 (25%) belonged to Group 1 and 9 (20.5%) to Group 2 (p = 0.55). Recurrence was found in 34 patients: 25 belonging to Group 1 and 9 corresponding to Group 2 (p = 0.65). Morbidity was of 4% in Group 1 and 9% in Group 2 (p = 0.23). With an average follow-up of 30.6 months, 5-year overall survival was of 87% in Group 1 and of 63% in Group 2 (p = 0.04). Conclusion:Advanced age was not associated with differences regarding positivity of SLN and recurrence but difference in overall survival was observed. According to our results and the low morbidity rate, we consider SLNB should not be omitted in such age group, since it improves staging and gives the possibility to evaluate adjuvant treatment.

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Section: Discussionmentioning

confidence: 99%

Role of sentinel lymph node biopsy for cutaneous melanoma in elderly patients: preliminary results in a Latin-American population

Featherston¹,

Nardi²,

Tomé³

et al. 2021

ecancer

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“…Within the pathophysiology of melanoma and factors associated with its development, chronic solar exposure has been described as an important factor, especially in some types of melanoma. 23 , 24 However, the value of the finding described in this investigation lies in the role this risk exposure plays as a poor prognosis factor for these patients, both for OS and RFS. It is important because it makes it possible to demonstrate the importance of prevention against this factor, which is not only associated with the occurrence of the event but is also associated with two bad prognostic outcomes in this population.…”

Section: Discussionmentioning

confidence: 74%

Clinical Outcomes and Prognostic Factors of Patients With Early Malignant Melanoma in One Latin American Country: Results of the Epidemiological Registry of Malignant Melanoma in Colombia Study

Ospina

Contreras

Triana

et al. 2023

JCO Global Oncology

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To describe the population with early malignant melanoma, we performed a cohort study on the basis of the Epidemiological Registry of Malignant Melanoma in Colombia-Asociacion Colombiana de Hematologia y Oncologia. From January 2011 until December 2021, 759 patients were included; the average age was 66 years, 57% were women, acral lentiginous histology was found in 27.8% of patients, and the median follow-up was 36.5 months. The prognostic factors for overall survival in our population are Eastern Cooperative Oncology Group 3-4 (hazard ratio [HR], 13.8), stage III (HR, 5.07), received radiotherapy (HR, 3.38), ulceration on histology (HR, 2.68), chronic sun exposure (HR, 2.3), low income (HR, 2.04), previous local surgery (HR, 0.27), and have received adjuvant treatment (HR, 0.41).

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“…Em uma revisão sistemática, identificou características de alto risco para melanoma da pele, como presença de nódulos numerosos, nódulos grandes, nódulos congestos, indivíduos com pele clara e história familiar, foram consistentemente mencionadas (Yeung et al, 2020). Nova et al (2020) relata que essa associação pode envolver dois aspectos, sendo o primeiro, está relacionado ao fator genético que implica diretamente na determinação do risco de desenvolvimento desses tumores (características fenotípicas, síndromes hereditárias, genes específicos do tumor). Segundo, tem de ser ponderado os fatores ambientes que por viverem em um mesmo ambiente, indivíduos de uma mesma família estão expostos aos mesmos fatores, tornando-as suscetíveis ao desenvolvimento das mesmas doenças.…”

Section: Discussionunclassified

A relevância do diagnóstico precoce do câncer de pele na população de meia idade e idosos: Revisão de escopo

Carneiro,

Amorim,

Silva

et al. 2024

RSD

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Objetivos: Analisar as estratégias de prevenção para o rastreio precoce do câncer de pele, bem como sinais e sintomas que muitas vezes são tardios e identificar os fatores associados ao sugimento de neoplasia cutânea em indivíduos de meia idade e idosos. Metodologia: Scoping Review, baseado nos procedimentos recomendados pelo Instituto Joanna Briggs. Estabeleceu-se a pergunta norteadora: “Qual a relevância do diagnóstico precoce do câncer de pele na população de meia idade e idosos e quais as práticas de enfermagem no contexto da prevenção do câncer de pele?”. Serão realizadas buscas em três bases de dados nacionais e internacionais, sobre trabalhos publicados de 2018 a 2023. Resultados: Foram identificados 1.443 estudos dos quais, 53 eram duplicatas e 1.189 foram excluídos. Com base no título e resumo, 201 estudos foram avaliados e 35 estudos seguiram por elegibilidade para etapa de leitura do texto completo. Para essa revisão de escopo rápida, 8 estudos foram incluídos. Discussão: As evidências encontradas no escopo deste estudo demonstraram que as campanhas de prevenção as principais estratégias de prevenção para detecção precoce do câncer de pele. Além de resultados que mostram a idade, histórico familiar, tabagismo e exposição solar como os principais fatores de riscos para o desenvolvimento da doença. Considerações Finais: Os resultados deste estudo reafirmam a relevância de intensificar ações preventivas no contexto da promoção da saúde, principalmente no que se refere ao diagnóstico precoce e conscientização da população, devendo ser constantemente estimulados.

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Melanoma risk factors in a Latin American population

Cited by 6 publications

References 4 publications

Role of sentinel lymph node biopsy for cutaneous melanoma in elderly patients: preliminary results in a Latin-American population

Role of sentinel lymph node biopsy for cutaneous melanoma in elderly patients: preliminary results in a Latin-American population

Clinical Outcomes and Prognostic Factors of Patients With Early Malignant Melanoma in One Latin American Country: Results of the Epidemiological Registry of Malignant Melanoma in Colombia Study

A relevância do diagnóstico precoce do câncer de pele na população de meia idade e idosos: Revisão de escopo

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