Annular epidermolytic ichthyosis: a case report and literature review

Newborn Girl Presenting With Erythema and Blisters

“…Keratin variations result in increased transepidermal water loss and inflammation on exposure to noxious environmental factors . Typical features of AEI include superficial erosions, vesicles and bullae with or without erythema early on, and recurrent migratory annular and polycyclic erythematous plaques on the trunk and extremities . Palmoplantar keratoderma (PPK) is associated with KRT1 variations, rather than those of KRT10 .…”

“…4 Typical features of AEI include superficial erosions, vesicles and bullae with or without erythema early on, and recurrent migratory annular and polycyclic erythematous plaques on the trunk and extremities. 5 Palmoplantar keratoderma (PPK) is associated with KRT1 variations, rather than those of KRT10. 2,3 Original magnification ×50 During the intermittent period, all lesions, excluding PPK in patients with KRT1 variations, demonstrate near-complete resolution, distinguishing AEI from the major EI forms.…”

“…4 Typical features of AEI include superficial erosions, vesicles and bullae with or without erythema early on, and recurrent migratory annular and polycyclic erythematous plaques on the trunk and extremities. 5 Palmoplantar keratoderma (PPK) is associated with KRT1 variations, rather than those of KRT10. 2,3 During the in-…”