High rate of sensitization to Kathon CG, detected by patch tests in patients with suspected allergic contact dermatitis

Silva, Eliane Aparecida; Bosco, Marcia Regina Miras; Lozano, Rejane Rojas; Latini, Ana Carla Pereira; Souza, Vânia Niéto Brito de

doi:10.1016/j.abd.2019.09.026

Cited by 2 publications

(1 citation statement)

References 19 publications

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“…Other authors also reported that the most frequent involvement was the hands (33.3%), followed by the face (26.5%) (32). In a study that evaluated the Brazilian series, with a 0.5% sensitization to MCI/MI, it was also found that the hands were the most affected site (58.6%), followed by the head, face, and neck (48.3%) (33).…”

Section: F O R P U B L I C a T I O Nmentioning

confidence: 90%

Prospective study of consecutive patch testing in patients with contact dermatitis using an adapted Latin American baseline series

Belluco

Giavina‐Bianchi

Belluco

et al. 2023

Eur Ann Allergy Clin Immunol

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Background: Contact dermatitis is a disease characterized by pruritic skin lesions with high prevalence rates. The patch test is an instrument to evaluate contact allergies. Current data on characteristics of the affected population and studies about patch testing using adequate baseline series are needed. Objectives:To describe the clinical and epidemiological characteristics of a population with suspected contact dermatitis who underwent to a patch testing using an adapted Latin American baseline series in the departments of allergy and dermatology of a referral center in Brasília, Brazil, between March and December 2020.Methods: Observational, descriptive and analytical clinical study with prospective data collection was performed in consecutively evaluated patients at a referral center. The results of 208 participants who underwent patch testing using an adapted Latin American baseline series containing 40 allergens were analyzed, and the prevalence of contact allergies was compared with data from the literature. Pearson's chi-square test was used to calculate the odds ratio and respective 95% confidence interval for qualitative variables. Quantitative variables were compared using the Mann-Whitney U test. The four most prevalent allergens were entered into multiple binary logistic regression models as response variables to identify the main explanatory variables associated with these allergies. The significance of the regression parameters was tested using the Wald statistical test. Results:The mean age of participants was 42.6 years. A total of 69.7% had one or more positive tests. Among those with positive tests, 82.8% were women (OR = 1.371; p = 0.398). The hands were the most commonly affected site at 43%. An occupational history was detected in 19.2%. The most common allergen was nickel sulfate (32.2%), followed by sodium tetrachloropalladate (19.7%), fragrance mix I (15.4%), and methylisothiazolinone (13.5%). In multivariate logistic regression models, nickel was significantly related to female sex (p < 0.05), as well as palladium (p < 0.05). Fragrance mix I was related to a family history of allergy (p < 0.05). On the other hand, methylisothiazolinone was statistically significantly related to face (p < 0.05) and hand (p < 0.001) lesions. Conclusion:This study demonstrated a detailed profile of a population with suspected allergic contact dermatitis. Our patch test results, using an adapted Latin American baseline series, represent a significant update of this important diagnostic tool.

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Section: F O R P U B L I C a T I O Nmentioning

confidence: 90%

Prospective study of consecutive patch testing in patients with contact dermatitis using an adapted Latin American baseline series

Belluco

Giavina‐Bianchi

Belluco

et al. 2023

Eur Ann Allergy Clin Immunol

View full text Add to dashboard Cite

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Polyphenols: Natural Preservatives with Promising Applications in Food, Cosmetics and Pharma Industries; Problems and Toxicity Associated with Synthetic Preservatives; Impact of Misleading Advertisements; Recent Trends in Preservation and Legislation

et al. 2023

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The global market of food, cosmetics, and pharmaceutical products requires continuous tracking of harmful ingredients and microbial contamination for the sake of the safety of both products and consumers as these products greatly dominate the consumer’s health, directly or indirectly. The existence, survival, and growth of microorganisms in the product may lead to physicochemical degradation or spoilage and may infect the consumer at another end. It has become a challenge for industries to produce a product that is safe, self-stable, and has high nutritional value, as many factors such as physical, chemical, enzymatic, or microbial activities are responsible for causing spoilage to the product within the due course of time. Thus, preservatives are added to retain the virtue of the product to ensure its safety for the consumer. Nowadays, the use of synthetic/artificial preservatives has become common and has not been widely accepted by consumers as they are aware of the fact that exposure to preservatives can lead to adverse effects on health, which is a major area of concern for researchers. Naturally occurring phenolic compounds appear to be extensively used as bio-preservatives to prolong the shelf life of the finished product. Based on the convincing shreds of evidence reported in the literature, it is suggested that phenolic compounds and their derivatives have massive potential to be investigated for the development of new moieties and are proven to be promising drug molecules. The objective of this article is to provide an overview of the significant role of phenolic compounds and their derivatives in the preservation of perishable products from microbial attack due to their exclusive antioxidant and free radical scavenging properties and the problems associated with the use of synthetic preservatives in pharmaceutical products. This article also analyzes the recent trends in preservation along with technical norms that regulate the food, cosmetic, and pharmaceutical products in the developing countries.

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High rate of sensitization to Kathon CG, detected by patch tests in patients with suspected allergic contact dermatitis

Cited by 2 publications

References 19 publications

Prospective study of consecutive patch testing in patients with contact dermatitis using an adapted Latin American baseline series

Prospective study of consecutive patch testing in patients with contact dermatitis using an adapted Latin American baseline series

Polyphenols: Natural Preservatives with Promising Applications in Food, Cosmetics and Pharma Industries; Problems and Toxicity Associated with Synthetic Preservatives; Impact of Misleading Advertisements; Recent Trends in Preservation and Legislation

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