Cutaneous manifestations of bartonellosis

Lins, Karina de Almeida; Drummond, Marina Rovani; Velho, Paulo Eduardo Neves Ferreira

doi:10.1016/j.abd.2019.09.024

Cited by 39 publications

(24 citation statements)

References 79 publications

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“…The genus Bartonella consists of numerous species, some of which are known to cause Trench fever, Carrion’s disease, and cat scratch disease (CSD) [ 2 ]. Trench fever, originally described more than 100 years ago as infecting nearly one million troops during World War I, is caused by B. quintana [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

What Is in a Cat Scratch? Growth of Bartonella henselae in a Biofilm

2021

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Bartonella henselae (B. henselae) is a gram-negative bacterium that causes cat scratch disease, bacteremia, and endocarditis, as well as other clinical presentations. B. henselae has been shown to form a biofilm in vitro that likely plays a role in the establishment and persistence of the bacterium in the host. Biofilms are also known to form in the cat flea vector; hence, the ability of this bacterium to form a biofilm has broad biological significance. The release of B. henselae from a biofilm niche appears to be important in disease persistence and relapse in the vertebrate host but also in transmission by the cat flea vector. It has been shown that the BadA adhesin of B. henselae is critical for adherence and biofilm formation. Thus, the upregulation of badA is important in initiating biofilm formation, and down-regulation is important in the release of the bacterium from the biofilm. We summarize the current knowledge of biofilm formation in Bartonella species and the role of BadA in biofilm formation. We discuss the evidence that defines possible mechanisms for the regulation of the genes required for biofilm formation. We further describe the regulation of those genes in the conditions that mimic both the arthropod vector and the mammalian host for B. henselae. The treatment for persistent B. henselae infection remains a challenge; hence, a better understanding of the mechanisms by which this bacterium persists in its host is critical to inform future efforts to develop drugs to treat such infections.

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Section: Introductionmentioning

confidence: 99%

What Is in a Cat Scratch? Growth of Bartonella henselae in a Biofilm

2021

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“…Our patient did not have Osler's nodes or Janeway lesions, but he did present with purpura in his lower extremities, which was reminiscent of ANCA-related vasculitis. Lin et al reported on the cutaneous manifestations of bartonellosis ( 14 ). In their review, they cited the paper from Teoh et al, reporting that vasculitis can be induced by bartonellosis and even simulate systemic vasculitis with ANCA positivity ( 15 ).…”

Section: Discussionmentioning

confidence: 99%

Glomerulonephritis Caused by <i>Bartonella</i> spp. Infective Endocarditis: The Difficulty and Importance of Differentiation from Anti-neutrophil Cytoplasmic Antibody-related Rapidly Progressive Glomerulonephritis

et al. 2021

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A 65-year-old man with valvular disorder presented to his physician because of widespread purpura in both lower extremities. Blood tests showed elevated serum creatinine levels and proteinase 3-anti-neutrophil cytoplasmic antibody (ANCA) with hematuria, suggesting ANCA-related rapidly progressive glomerulonephritis (RPGN). Although multiple blood cultures were negative, transthoracic echocardiography revealed warts in the valves, and a renal biopsy also showed findings of glomerular infiltration by mononuclear leukocytes and C3 deposition in the glomeruli, suggesting infection-related glomerulonephritis. Later, Bartonella antibody turned positive. Antimicrobial treatment improved the purpura and renal function without any recurrence. ANCA-positive RPGN requires the exclusion of infective endocarditis, especially that induced by Bartonella spp.

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“…In addition to cat scratch disease, Bartonella henselae causes from asymptomatic bacteraemia to potentially fatal diseases, and, certainly due to the lack of knowledge on the part of health professionals and the consequent weakness in diagnosis, it has not been correctly diagnosed (Lins et al, 2019). Transmission to the individual occurs through scratches from domestic cats or wild cats, usually asymptomatic, infested with infected fleas.…”

Section: Introductionmentioning

confidence: 99%

Serological evidence of Bartonellosis in an indigenous community in the Brazilian Legal Amazonia

Vivi-Oliveira

Pessoa

Lacerda

et al. 2021

Zoonoses and Public Health

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Background: Due to immunological susceptibility, close contact with the environment and way of life, indigenous communities are in a highly vulnerable condition to be affected by zoonoses, such as bartonellosis. Methods: Seventy three paired serum samples were collected from indigenous people from a region of the Brazilian Legal Amazon, in cohorts carried out in 2014 and 2015, with the performance of serological tests by indirect immunofluorescence to detect anti-Bartonella IgG antibodies. The interviews and laboratory results were double entered in the EpiInfo 7 software, and the data processing was performed in the MiniTab 17 software.Results: 5.47% of the indigenous people were seroreagent. The female gender was predominant (65.75%), aged between 20 and 39 years old (39.73%) with complete elementary school (42.47%). As for housing, wooden residences predominated (50.68%). Rodents were seen by 46.58% of the interviewees, and 55.88% of them reported that the animal was close to or inside the house. It was identified that each indigenous family, in its majority, had four to six cats, for the function of hunters of rodents. Conclusion:The high concentration of domestic cats, the close contact of indigenous people with wild rodents and the lack of care and poor hygiene of both are aspects that imply the possibility of infection by Bartonella sp. Health surveillance through seroepidemiological studies is essential to find evidence of the circulation of bartonellosis in these populations.

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Cutaneous manifestations of bartonellosis

Cited by 39 publications

References 79 publications

What Is in a Cat Scratch? Growth of Bartonella henselae in a Biofilm

What Is in a Cat Scratch? Growth of Bartonella henselae in a Biofilm

Glomerulonephritis Caused by <i>Bartonella</i> spp. Infective Endocarditis: The Difficulty and Importance of Differentiation from Anti-neutrophil Cytoplasmic Antibody-related Rapidly Progressive Glomerulonephritis

Serological evidence of Bartonellosis in an indigenous community in the Brazilian Legal Amazonia

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