Neurofibromatosis with vitiligo: an uncommon association rather than coexistence?

Tandon, Sidharth; Singh, Ajeet; Arora, Pooja; Gautam, R. K.

doi:10.1016/j.abd.2019.09.003

Cited by 1 publication

(1 citation statement)

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“…Behavioral problems include impaired socialization, sleep disturbance, anxiety and depression (4,5,12). Other associated autoimmune diseases have been previously described as uncommon occurrences, such as lichen sclerosus or vitiligo (29)(30)(31)(32)(33)(34).…”

Section: Introductionmentioning

confidence: 99%

Orthopaedic manifestations of neurofibromatosis type 1: A case report

et al. 2021

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Neurofibromatosis type 1 (NF1) or von Recklinghausen disease is one of the most common autosomal dominant genetic diseases. It is characterized by 'café-au-lait' spots and multiple tumors starting from the central and peripheric nervous system. The diagnosis is determined on two out of seven criteria: i) A total of 6 or more light brown spots larger than 5 mm in diameter (pre-puberty) or 15 mm in diameter (post-puberty); ii) a total of 2 or more neurofibromas or one plexiform neurofibroma; iii) axillary or inguinal freckling; iv) optic glioma; v) a total of 2 or more Lisch nodules; vi) bone abnormalities: tibia pseudarthrosis or dysplasia of the sphenoid wing; and vii) a relative of first degree having an NF1 diagnosis. A total of ~50% of patients have significant musculoskeletal manifestation, with scoliosis and congenital pseudarthrosis of tibia most common. Management of the orthopaedic manifestations of NF1 is often difficult. Due to NF1 influencing multiple organ systems, patients are likely to benefit most from a multidisciplinary treatment strategy.

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