Dermoscopic pattern of Kyrle's disease

Özbağçıvan, Özlem; Lebe, Banu; Fetil, Emel

doi:10.1016/j.abd.2019.07.007

Cited by 7 publications

(6 citation statements)

References 8 publications

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“…KD is diagnosed based on characteristic clinical and histopathologic findings. Dermoscopy has been shown to facilitate the clinical recognition and can be a helpful tool in making a conclusion in the direction of KD diagnosis [22] . It did help in our case.…”

Section: Discussionmentioning

confidence: 99%

Longstanding, Repetitively Misdiagnosed Kyrle’s Disease in a Patient With End-Stage Renal Disease: A Case Report

Karajovanov

Nikolovska

Gocev

et al. 2023

AMJ

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Kyrle's disease (KD) is a rare variant of acquired perforating dermatosis (APD), associated with systemic diseases in adults, particularly chronic kidney disease (CKD) and diabetes mellitus (DM). Hyperkeratotic papules of KD are clinically important as a sign of a systemic disorder that are often misdiagnosed, so clinicopathological correlation is needed to establish the diagnosis. We report a rare case with longstanding KD, associated with endstage renal disease (ESRD) on hemodialysis for 25 years that was repetitively misdiagnosed as folliculitis, excoriations and prurigo nodularis. The KD skin changes started to develop during earlier stages of CKD, before the kidney disease was suspected, and continued to appear in flares with extensive lesions when the systemic disease in the background was not under control. Dermoscopy revealed a 3-zonal concentric pattern, characterized by bright whitish scales in the centre, a structureless whitish-grey area surrounding the central crusts, and a peripheral, rose/brown pigmentation. Histopathological examination revealed moderately acantathotic epidermal invagination filled with a keratotic plug admixed with cellular debris and neutrophils, and a modest parakeratosis. Our goal is to emphasize that the accurate and timely diagnosis is vital to be able to monitor patients for a life threating, systemic disease such as kidney failure, and attaining better management of the dermatological status which can become longstanding and hindering, as well as to outline the importance of the multidisciplinary approach to improve outcomes in patients affected by KD.

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Section: Discussionmentioning

confidence: 99%

Longstanding, Repetitively Misdiagnosed Kyrle’s Disease in a Patient With End-Stage Renal Disease: A Case Report

Karajovanov

Nikolovska

Gocev

et al. 2023

AMJ

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“…Dermoscopic images of APD have not been fully summarized in the medical literature. [23][24][25] In our studies, we fully summarized the dermoscopic features of the complete APD process. The vessel pat- There is no uniform standard for the treatment of APD.…”

Section: Discussionmentioning

confidence: 99%

Acquired perforating dermatosis: A clinicopathologic study, and the features of dermoscopy and reflective confocal microscopy of 37 cases

Gao

Shan

2023

Skin Research and Technology

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Background: Acquired perforating dermatosis (APD) is a rare skin condition characterized by degenerated materials eliminated from the dermis. Several retrospective studies on APD have been reported; however, few data are available on Chinese APD and their features on dermoscopy and reflective confocal microscope (RCM) assays. Objective:The aim of this study was to retrospectively evaluate the clinical and histopathologic data of 37 acquired perforating dermatosis cases, and assess their features on dermoscopy and RCM.Methods: Thirty-seven APD patients were retrospectively enrolled in our study. We characterized the clinical histopathological features, concomitant diseases, treatment responses, and the dermoscopy and RCM findings.Results: Pruritus was the most common symptom, with the lower extremities as the most predilection sites (86.5%, n = 32; 91.9%, n = 34, respectively). Concomitant diseases were found in 34 patients (92.6%), among which diabetes mellitus was the most common, followed by thyroid nodules, allergic dermatosis, and chronic renal insufficiency. Dermoscopy and RCM assays were performed in 11 patients. The typical RCM images were hyperreflective cord-like structures from the epidermis to dermis. Dermoscopy features of fully developed lesions showed central ulceration with peripheral hairpin-like or loop-like capillaries with characteristic garland arrangements. Conclusion: APD is an uncommon skin disorder associated with various systemic conditions in Chinese individuals. Thyroid disorders are an overlooked complication and may play an important role in the development of APD. The results of this study indicate that noninvasive dermoscopy and RCM examination are helpful in the rapid diagnosis and early intervention of APD.

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“…The comparison of dermoscopic features of various perforating dermatoses is tabulated in Table 1 , which can help to differentiate PPPXE from other perforating disorders. [ 5 6 7 8 9 10 ]…”

Section: Discussionmentioning

confidence: 99%

Dermoscopic Intrusion into a Pathological Extrusion

Rajamanickam,

Murthy,

Karthikeyan

2023

Indian Dermatology Online Journal

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Dermoscopic pattern of Kyrle's disease

Cited by 7 publications

References 8 publications

Longstanding, Repetitively Misdiagnosed Kyrle’s Disease in a Patient With End-Stage Renal Disease: A Case Report

Longstanding, Repetitively Misdiagnosed Kyrle’s Disease in a Patient With End-Stage Renal Disease: A Case Report

Acquired perforating dermatosis: A clinicopathologic study, and the features of dermoscopy and reflective confocal microscopy of 37 cases

Dermoscopic Intrusion into a Pathological Extrusion

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