Worse survival of invasive melanoma patients in men and “de novo” lesions

Giavina-Bianchi, Mara; Festa-Neto, Cyro; Sanches, José Antônio; Teixeira, Magaly Gêmio; Waldvogel, Bernadette Cunha

doi:10.1016/j.abd.2019.07.003

Cited by 5 publications

(6 citation statements)

References 16 publications

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“…Survival in the men and in the patients with advanced skin malignant melanoma in our study was significantly lower, which is in line with the data from two large-scale studies conducted in Brazil [ 40 ] and Europe [ 41 ]. However, the 5-year survival rates of 95.7% and 85%, respectively, are substantially higher than the 63% survival rate established by us.…”

Section: Discussionsupporting

confidence: 92%

Re-excision within a radius of 2 cm in patients with melanoma of the skin – sufficient for local oncological radicalness

et al. 2020

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Introduction: Malignant melanoma is one of the most malignant tumours in the human body. Radical re-excision of the tumour bed is a principal part of its surgical treatment. We aim to test the hypothesis that the re-excision with a 2 cm margin in all directions to the scar from the previous biopsy of the primary tumour provides sufficient local control in patients with this disease. Material and methods: This is a prospective descriptive study using STROBE methods, including all 151 patients with malignant melanoma of the skin, diagnosed and treated at the

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Section: Discussionsupporting

confidence: 92%

Re-excision within a radius of 2 cm in patients with melanoma of the skin – sufficient for local oncological radicalness

et al. 2020

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“…In relation to survival related to different histological melanoma subtypes, our study did not demonstrate statistically significant differences in survival among the three most common subtypes encountered (superficial spreading melanoma, nodular melanoma and acral melanoma). This contrasts with the findings of Giavina‐Bianchi et al., 50 who examined 565 cases of invasive melanoma and analyzed disease‐specific survival according to histological type and the Breslow Index. In their study, univariate analysis showed significant differences in survival between the subtypes; however in multivariate analysis with adjusted hazard ratios, they found no significant correlation between histological type and survival.…”

Section: Discussioncontrasting

confidence: 71%

Macroscopic tumor dimension, sentinel lymph node outcome, and survival analysis among cutaneous melanoma

Asato,

Moraes‐Neto,

Moraes

et al. 2024

Int J Dermatology

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BackgroundCutaneous melanoma is characterized by a high risk of metastasis to distant organs and a substantial mortality rate. For planning treatment and assessing outcomes, the Breslow micrometric measurement is critical. The tumor macroscopic dimension is not considered a prognostic parameter in cutaneous melanoma, although there are studies showing that tumor size is an independent prognostic factor for melanoma‐specific survival. Therefore, this study aimed to evaluate the macroscopic dimension of melanoma and other known prognostic factors (i.e., Breslow index, mitoses, regression, and ulceration) as predictors of sentinel lymph node outcome and survival outcome.MethodsWe performed a retrospective cross‐sectional study of 227 melanoma lesions subjected to sentinel lymph node biopsy at two Brazilian referral centers.ResultsOn univariate analysis, there was a statistically significant correlation between the largest macroscopic tumor dimension and the sentinel lymph node result (P = 0.001); however, on multivariate analysis considering all evaluated parameters, there was no significant difference between the sentinel lymph node result and the tumor macroscopic dimension (P = 0.2689). Regarding melanoma‐specific survival, the macroscopic dimension showed no significant correlation (P = 0.4632) in contrast to Breslow's dimension (P < 0.0001).ConclusionThe Breslow thickness was the only significant factor related to both the sentinel lymph node outcome and melanoma specific survival among the evaluated variables.

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“…Given the associations of the de novo subtype with increased tumour thickness and nodular histotype, one would have expected at least an association with shorter survival in univariate analysis. Their finding is in contrast to two relatively large recent studies, including an analysis of a prospective cohort, that found that de novo classification was an independent predictor of worse survival 7,8 . The current study has several limitations to the survival analysis including the retrospective collection of patients, the short median follow‐up (~2·7 years), and the collection of datasets from seven centres with different staging and follow‐up protocols.…”

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confidence: 59%

“…Dermatologists are well placed to manage such conditions and therefore should be more involved in cellulitis care. The Norwich model has shown the value of dermatological input for cellulitis, 8 particularly as red legs do not always mean cellulitis and mismanagement frequently occurs. 9…”

mentioning

confidence: 99%

“…Their finding is in contrast to two relatively large recent studies, including an analysis of a prospective cohort, that found that de novo classification was an independent predictor of worse survival. 7,8 The current study has several limitations to the survival analysis including the retrospective collection of patients, the short median follow-up (~2Á7 years), and the collection of datasets from seven centres with different staging and follow-up protocols. One particular limitation is the exclusion of patients with stage III disease.…”

mentioning

confidence: 99%

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Melanoma origins: data from early‐stage tumours supports de novo and naevus‐associated melanomas as distinct subtypes

Wiggins

Polsky

2021

Br J Dermatol

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Worse survival of invasive melanoma patients in men and “de novo” lesions

Cited by 5 publications

References 16 publications

Re-excision within a radius of 2 cm in patients with melanoma of the skin – sufficient for local oncological radicalness

Re-excision within a radius of 2 cm in patients with melanoma of the skin – sufficient for local oncological radicalness

Macroscopic tumor dimension, sentinel lymph node outcome, and survival analysis among cutaneous melanoma

Melanoma origins: data from early‐stage tumours supports de novo and naevus‐associated melanomas as distinct subtypes

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