Cutaneous sarcoidosis: clinico–epidemiological profile of 72 patients at a tertiary hospital in São Paulo, Brazil

Torquato, Mariana Fernandes; Costa, Marcella Karen Souza da; Nico, Marcello Menta Simonsen

doi:10.1016/j.abd.2019.06.004

Cited by 9 publications

(22 citation statements)

References 20 publications

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“…The most common clinical cutaneous manifestation in our cohort, were papular eruptions (43%). Comparing this data to cohort studies of different ethnic groups showed similiar results with papules ( 8 , 9 , 12 , 16 , 17 ) and plaques ( 11 , 13 , 14 ) being the most common skin features in cutaneous sarcoidosis. Our study demonstrated that sarcoid skin lesions were highly associated with additional systemic involvement.…”

Section: Discussionmentioning

confidence: 56%

“…All our cutaneous sarcoidosis patients with systemic involvement showed bilateral hilar lymphadenopathy, of whom almost 50% also had an impaired lung function. Lung involvement in cutaneous sarcoidosis is frequent ( 8 – 10 , 12 , 13 , 15 – 17 , 22 ). The other organ manifestations were less pronounced, such as arthritis (30%), splenomegaly (16%) and uveitis (5%).…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of clinical and laboratory characteristics of patients with cutaneous sarcoidosis: A single-center retrospective cohort study

et al. 2022

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BackgroundCutaneous sarcoidosis is a relatively rare disease whose clinical manifestations include red-brown macules, plaques, papules and subcutaneous nodules. The skin changes may also be restricted to pre-existing scars. Cutaneous sarcoidosis can be associated with systemic organ involvement.ObjectivesAim of this retrospective study was to longitudinally investigate clinical and laboratory findings in patients with cutaneous sarcoidosis.MethodsPatients (>18 years) with histologically confirmed cutaneous sarcoidosis between January 2014 and December 2020 were included. Patient demographics, clinical features, laboratory and radiological findings, management, clinical outcomes and co-morbidities associated with cutaneous sarcoidosis were analyzed.ResultsThirty-seven patients with cutaneous sarcoidosis were identified, of whom 57% were female. The most common clinical phenotype of cutaneous sarcoidosis was papular sarcoidosis (n = 16), while plaques and nodules were present in 9 patients. In contrast, subcutaneous (n = 1) and scar-associated sarcoidosis (n = 1) were rare. Of patients with systemic disease, the cutaneous disease followed, preceded, and coincided with the development of systemic sarcoidosis in 2, 9, and 12 patients, respectively. Levels of soluble interleukin (IL)-2 receptor, angiotensin converting enzyme (ACE), and C-reactive protein (CRP) were elevated, in 76%, 21%, and 50% of the tested patients respectively and predicted systemic involvement. Hypercalcemia was present in 6% of patients. Female sex and younger age (<54 years) were significantly associated with systemic manifestations.ConlcusionsCutaneous sarcoidosis was frequently associated with additional systemic involvement, particularly when present in young females. 24 % of patients with cutaneous sarcoidosis developed additional organ involvement during follow-up.

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Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Evaluation of clinical and laboratory characteristics of patients with cutaneous sarcoidosis: A single-center retrospective cohort study

et al. 2022

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“…In general, early diagnosis is also beneficial. [5][6][7][8][9] Maculopapular Sarcoidosis It is the most common form. It is frequently localized on the face, especially around the eyes and nasolabial fold, but may also involve the occipital part of the neck, trunk, extremities, and mucous membranes.…”

Section: Dermatological Findingsmentioning

confidence: 99%

Sarcoidosis and skin manifestations

Yazıcı,

Hoşgün

2024

JOPIC

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Sarcoidosis is a multisystemic inflammatory disease of unknown etiology, affecting all organs and systems. Skin involvement is seen in one-third of cases. Cutaneous findings alone do not determine the prognosis of sarcoidosis, but they are useful in early diagnosis. There are specific and nonspecific cutaneous findings. The most common cutaneous findings are papules and plaques. This review summarizes the cutaneous manifestations of sarcoidosis.

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“…A sarcoidose é uma doença granulomatosa crônica, multissistêmica e de etiologia desconhecida. A pele é afetada entre nove e 37% dos casos 1,2 . A histopatologia é caracterizada pela presença de granulomas não caseosos, com pouca ou nenhuma quantidade de linfócitos circundantes (granuloma desnudo) 2,3 .…”

Section: Introdução|unclassified

“…A pele é afetada entre nove e 37% dos casos 1,2 . A histopatologia é caracterizada pela presença de granulomas não caseosos, com pouca ou nenhuma quantidade de linfócitos circundantes (granuloma desnudo) 2,3 . Clinicamente, pápulas e placas são as lesões mais observadas, mas se descreve ampla variabilidade morfológica de lesões na pele, tais como psoriasiformes, ictiosiformes, atróficas e ulcerativas [2][3][4] .…”

Section: Introdução|unclassified

Sarcoidose: polimorfismo lesional em um paciente

Moura¹,

Diniz²,

Lucas³

et al. 2023

RBPS

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A sarcoidose é uma doença granulomatosa crônica e multissistêmica de etiologia desconhecida. A pele é afetada entre 9 e 37% dos casos. A histopatologia se caracteriza pela formação de granulomas não caseosos, com pouca ou nenhuma quantidade de linfócitos circundantes. Clinicamente, pápulas e placas são as lesões mais observadas, mas é descrita ampla variabilidade morfológica de lesões cutâneas, como psoriasiformes, ictiosiformes, atróficas e ulcerativas. Relatamos um caso de sarcoidose sistêmica com envolvimento cutâneo em quatro localizações e manifestações clínicas distintas em cada uma delas.

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Cutaneous sarcoidosis: clinico–epidemiological profile of 72 patients at a tertiary hospital in São Paulo, Brazil

Cited by 9 publications

References 20 publications

Evaluation of clinical and laboratory characteristics of patients with cutaneous sarcoidosis: A single-center retrospective cohort study

Evaluation of clinical and laboratory characteristics of patients with cutaneous sarcoidosis: A single-center retrospective cohort study

Sarcoidosis and skin manifestations

Sarcoidose: polimorfismo lesional em um paciente

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