Success in the use of oral propranolol in the treatment of infantile hemangioma in nasal tip – Report of two cases

Costa, Mariana Carvalho; Andrade, Odil Garrido Campos de; Pereira, Lethícia de Castro; Costa, Izelda Maria Carvalho

doi:10.1016/j.abd.2019.05.005

Cited by 2 publications

(1 citation statement)

References 10 publications

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“…3 Nowadays, oral propranolol is proven to be the first-line medication in IHs. [46][47][48] The exploration of local administration pathway as local injection and topical application is in progress. 49 IHs are the most usual infantile soft tissue benign neoplasms.…”

Section: Use Of Propranolol In Ihsmentioning

confidence: 99%

Propranolol in the Treatment of Infantile Hemangiomas

Tan¹,

Guo²,

Wang³

2021

CCID

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Propranolol, as the first generation of β-blocker family, was initially introduced in the clinical application for tachycardia and hypertension in the 1960s. However, the occasional discovery of propranolol in the involution of infantile hemangiomas (IHs) brought us a new perspective. IHs are the most common infantile tumor, affecting 4–10% newborns. So far, oral propranolol is the first-line medication for IHs treatment. At the same time, local injection and topical propranolol are developing. Despite the worldwide application, the precise mechanism of propranolol of IHs has not been completely studied. In this article, we reviewed and summarized the current information on pharmacology, mechanism, efficacy, and adverse effects of propranolol. Novel design of biomaterials and bioactive molecules are needed for new treatment and ideal pathway to attain the minimal effective treatment concentration and eliminate the adverse effects.

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Section: Use Of Propranolol In Ihsmentioning

confidence: 99%

Propranolol in the Treatment of Infantile Hemangiomas

Tan¹,

Guo²,

Wang³

2021

CCID

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Treatment for Sequelae after Infantile Hemangioma Involution on the Body Surface

Nomura

Takeda

Terashi

2023

JJSLSM

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Sequelae after infantile hemangioma involution on the body surface includes telangiectasia, residual fibrous adipose tissue, skin atrophy and excess skin, and scarring, which occur at a relatively high rate. A pulsed dye laser is effective for telangiectasia. Surgical treatment is required for residual fibrofatty tissue, skin atrophy, excess skin and scars. Further research is needed on the issue of how to avoid sequelae in order to reduce the burden on patients.

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Success in the use of oral propranolol in the treatment of infantile hemangioma in nasal tip – Report of two cases

Cited by 2 publications

References 10 publications

Propranolol in the Treatment of Infantile Hemangiomas

Propranolol in the Treatment of Infantile Hemangiomas

Treatment for Sequelae after Infantile Hemangioma Involution on the Body Surface

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