Clinical characteristics and associations of palmoplantar pustulosis: an observational study

Öktem, Ayşe; Uysal, Pınar Incel; Akdoğan, Neslihan; Tokmak, Aslı; Yalçın, Başak

doi:10.1016/j.abd.2019.04.008

Cited by 7 publications

(7 citation statements)

References 22 publications

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“…This cross-sectional study found that the prevalence and age distribution of PPP in Korea were comparable to data reported in previous studies . Unlike previous studies, the male to female ratio in the current study was relatively even, which may be a result of differences in study design, sample size, or participant race .…”

Section: Discussionsupporting

confidence: 75%

Risks of Comorbidities in Patients With Palmoplantar Pustulosis vs Patients With Psoriasis Vulgaris or Pompholyx in Korea

et al. 2022

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Section: Discussionsupporting

confidence: 75%

Risks of Comorbidities in Patients With Palmoplantar Pustulosis vs Patients With Psoriasis Vulgaris or Pompholyx in Korea

et al. 2022

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“…As seen in previous cohorts, there was a strong female predominance, and a history of smoking was more common than in the general population (38.1% vs 14.0%). 4,[8][9][10] Currently, there are no US Food & Drug Administrationapproved treatments specifically for PPP. A Cochrane review that included 37 studies (1663 participants; mean [range] age, 50 [34-63] years; 24% were men) concluded that evidence is lacking for all major long-term PPP treatments (superpotent corticosteroids, phototherapy, acitretin, methotrexate, and cyclosporine), and only low-and moderate-quality evidence is available for the efficacy of biologic agents.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of a Case Series of Patients With Palmoplantar Pustulosis in the United States

et al. 2022

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almoplantar pustulosis (PPP) is a limited form of pustular psoriasis characterized by persistent, sterile macroscopic pustules on the palms and/or soles and presents both in isolation and in patients with a history of plaque psoriasis. Previous research suggests there is a genetic overlap between PPP and plaque psoriasis, 1-4 but despite any similarities, there are also key differences. Palmoplantar pustulosis predominantly presents in women, while psoriasis occurs in men and women equally. Despite the limited body surface area associated with PPP compared with psoriasis, patients with palmoplantar psoriasis have been shown to experience greater health-related quality-of-life impairment than those with moderate to severe plaque psoriasis. 5,6 Finally, treatments for PPP and palmoplantar psoriasis are similar, but much less is known about the response to treatment in patients with PPP. The objective of this study is to describe the clinical characteristics, longitudinal disease course, treatments, and health care utilization in patients with PPP across the US. Methods Study Design and PopulationThis is a retrospective case series of adults (age ≥18 years) with a diagnosis of PPP made by a dermatologist between January 1, 2007, and December 31, 2018. Up to 10 potential cases were identified from each of 20 sites using electronic health records and/or site-specific databases, starting with cases seen most recently. All diagnoses were confirmed by the principal investigator at each site at the time of data entry, and only patients who met the European Rare and Severe Psoriasis Expert Network consensus definition for PPP-documentation of primary, persistent (<3 months), sterile, macroscopic pustules on the palms and/or soles, not occurring within psoriatic plaques 7 -and had a dermatology encounter with active pustular disease during the study period were included. This study was granted exempt status by the University of Penn-IMPORTANCE Palmoplantar pustulosis (PPP) is a is a chronic, orphan disease with limited epidemiological data. OBJECTIVE To describe the clinical characteristics, treatments, longitudinal disease course, and health care utilization in adults with PPP across the US.

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“…There are previous reports indicating that smoking is a common habit among PPP patients in general (72.9% of 48 cases; 1 men 74.7% of 203 cases, women 32.9% of 266 cases; 7 94.92% of 59 cases 10 ). The smoking rate was high among PAO patients, as well.…”

Section: Discussionmentioning

confidence: 92%

“…Palmoplantar pustulosis (PPP) is a disease in which pinhead‐sized aseptic pustules appear chronically and repeatedly on the palms of hands and soles of feet 1,2 . The incidence of PPP is higher in Japan (0.12%) than in Western countries (0.01–0.05%) 3 …”

Section: Introductionmentioning

confidence: 99%

Clinical characteristics and treatment status of pustulotic arthro‐osteitis: A single‐center study involving 51 cases

Kondo

Sakai

Kakutani

et al. 2021

The Journal of Dermatology

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Pustulotic arthro‐osteitis (PAO) is a major complication of palmoplantar pustulosis (PPP). In orthopedic surgery outpatient clinics, PPP patients with osteoarticular symptoms are seen frequently, but PAO's clinical features remain not well known. To determine Japanese patients’ clinical features and treatment status with PAO, we conducted a single‐center retrospective epidemiologic survey. Clinical features, including gender, age, smoking habit, the onset pattern, interval between skin manifestation and osteoarticular symptoms, and the incidence of sternoclavicular joint lesions, axial and peripheral joint lesions, were examined. The association between physical status and image findings by X‐ray, computed tomography, bone scintigraphy with Technetium99, or magnetic resonance imaging was evaluated. The distribution pattern of peripheral joint lesions and the treatment status were evaluated. We identified 51 patients, 10 men and 41 women, with PAO. The average age was 48 years and 59% were smokers. The frequency of onset patterns was skin‐leading type (63%), simultaneous onset (18%), and osteoarticular leading type (16%). The average interval between skin involvement and osteoarticular involvement in skin‐leading type was significantly longer than that in osteoarticular leading type (7.1 years vs. 2.0 years). A sternoclavicular joint (SCJ) lesion was detected in 65% cases, and the physical findings of SCJ were significantly related to the image findings. Axial and peripheral joint lesions were detected in the same ratio (23 cases, 45%). In the peripheral joints, the finger joint was the most common (26%), followed by the shoulder joint (21%). Patients were treated with nonsteroidal anti‐inflammatory drugs (76%), followed by conventional synthetic disease‐modifying antirheumatic drugs (DMARDs) (29%) and biological DMARDs (9.8%). Tonsillectomy was performed in 11 cases. In conclusion, PAO more frequently involves SCJ in middle‐aged women who smoke. Given that osteoarticular leading type was detected in 16% cases, seronegative oligoarthritis patients should be monitored for PPP, leading to a diagnosis of PAO.

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Clinical characteristics and associations of palmoplantar pustulosis: an observational study

Cited by 7 publications

References 22 publications

Risks of Comorbidities in Patients With Palmoplantar Pustulosis vs Patients With Psoriasis Vulgaris or Pompholyx in Korea

Risks of Comorbidities in Patients With Palmoplantar Pustulosis vs Patients With Psoriasis Vulgaris or Pompholyx in Korea

Evaluation of a Case Series of Patients With Palmoplantar Pustulosis in the United States

Clinical characteristics and treatment status of pustulotic arthro‐osteitis: A single‐center study involving 51 cases

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