Familial fibrosing frontal alopecia in six sisters

Rocha, Vanessa Barreto; Pires, Mário Cézar; Contin, Letícia Arsie

doi:10.1016/j.abd.2019.02.009

Cited by 4 publications

(6 citation statements)

References 4 publications

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“…Another important aspect seen in 50% of our cases was the presence of facial papules. This characteristic was only reported in 3 previous studies [7,12,16] (Table 2). Furthermore, no difference in regard to the clinical manifestations between familial and nonfamilial FFA subjects was stablished.…”

Section: Discussion/conclusionmentioning

confidence: 53%

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Frontal Fibrosing Alopecia: Is There a Link in Relatives?

Ocampo‐Garza

Orizaga-Y-Quiroga

Olvera-Rodríguez

et al. 2021

Skin Appendage Disord

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Frontal fibrosing alopecia (FFA) is an acquired primary lymphocytic cicatricial alopecia characterized by frontotemporal hairline recession, leading to scarring alopecia with a band-like distribution. Prevalence is increasing worldwide, being the most frequent cause of primary scarring alopecia. The natural history of this condition is variable; however, slow progression with spontaneous remission is the most frequent reported outcome. The etiopathogenesis of FFA remains to be elucidated; numerous hypotheses concerning hormonal effects, environmental factors, and genetic predisposition have been proposed. Special interest on genetic basis has emerged since the first familial case was reported. Only a few more familial cases have been published. We report 6 additional cases of female patients with familial FFA (F-FFA) from 3 different families. Sixty-six percent had a family history of autoimmune disease in first-degree relatives; these same patients had a personal history of autoimmune disease. The families described in this cohort study plus the personal and family history of autoimmune disease, as well as the recently described involved genomic loci; reinforced the hypothesis of this disease being genetic. It is important to consider studying this entity since there are scarce data regarding familial cases and this might give us a better insight toward understanding its pathogenesis.

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Section: Discussion/conclusionmentioning

confidence: 53%

“…However, subsequent reports revealed cases in younger women and rarely in men [3,4]. Although an autoimmune reaction and hormonal factors seem to play a role, numerous hypotheses regarding environmental factors and a genetic basis have recently been proposed [2,[5][6][7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Frontal Fibrosing Alopecia: Is There a Link in Relatives?

Ocampo‐Garza

Orizaga-Y-Quiroga

Olvera-Rodríguez

et al. 2021

Skin Appendage Disord

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“…The current case represents the 25 th and resulted in a total of 59 individual cases [Table 1]. 4,[7][8][9][10][11][12][13][14][15][16] Most affected family members were women (88%) but some families had both men and women (8%) who were affected; only one family presented with only affected males (4%). Analysis of the familial relationships showed that the most common relationship was between sisters (56%) followed by mother and daughter (32%) and brother and sister (8%).…”

Section: Case Reportsmentioning

confidence: 99%

“…5 Genetic factors have also been linked to this disease, as family cases reported in the literature to date suggest. 4,[7][8][9][10][11][12][13][14][15][16][17][18][19] Finally some authors have stated an autoimmune origin due to the inflammatory infiltrates in the bulb, the similarities to LPP and the association with other autoimmune diseases. 17 Family groups of FFA are an infrequently described phenomenon, with unknown prevalence among all cases of FFA.…”

Section: Case Reportsmentioning

confidence: 99%

Familial Frontal Fibrosing Alopecia

Cuenca‐Barrales

Ruiz‐Villaverde

Molina‐Leyva

2021

Sultan Qaboos Univ Med J

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Frontal fibrosing alopecia (FFA) is an emerging disease in Western countries. We present the cases of three sisters who were referred simultaneously to the Department of Dermatology, Hospital Universitario San Cecilio, Granada, Spain, in 2018. All patients suffered from at least partial frontotemporal hairline recession and eyebrow loss. Following trichoscopic examination, the three sisters were diagnosed with FFA. Only one of the sisters agreed to be treated; she was prescribed with topical clobetasol propionate solution and minoxidil and achieved disease control at the three-month follow-up. These patients represent a new case of familial FFA wherein three sisters as well as their mother were affected by FFA. A systematic review found a total of 24 cases of familial FFA, of which this report is the 25th. In the majority of families, only females were affected (88%) while in the remainder both males and females (8%) were affected; there was only one family where only males were affected (4%). The relationship between the affected individuals was predominately between sisters (56%) followed by mother and daughter (32%). The median age was 61 years old (range: 14–88 years) and the duration of the disease ranged between 3–360 months. Family groups of FFA are an infrequently described phenomenon with unknown prevalence. Keywords: Alopecia; Dermatology; Hair Diseases; Case Report; Spain.

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“…1). 8 They all lived in different homes and some resided in different cities prior to their disease onset. The aim of this study is to assess HLA genetic variability in a large familial cluster (six sisters and one daughter), unnafected brothers/sisters and sporadic cases of FFA.…”

Section: Introductionmentioning

confidence: 99%

A large familial cluster and sporadic cases of frontal fibrosing alopecia in Brazil reinforce known human leucocyte antigen (HLA) associations and indicate new HLA susceptibility haplotypes

Ramos

Garbers

Silva

et al. 2020

Acad Dermatol Venereol

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Background Frontal fibrosing alopecia (FFA) is a lymphocytic scarring alopecia whose worldwide incidence is rising. Environmental triggers combined with genetic predisposition represent one of the current hypotheses in FFA aetiology. Familial clusters are opportunities to investigate the genetic basis of diseases. Objectives Assess human leucocyte antigen (HLA) genetic variability in a Brazilian sample of a large familial cluster (six sisters and one daughter) with FFA, unnafected familiar members and sporadic cases of FFA. Methods We addressed the HLA-A, HLA-B, HLA-C, HLA-G and HLA-E genetic variability in this family and in seven sporadic FFA cases, comparing allele frequencies with those reported for the São Paulo State from Brazil. Results Two susceptibility haplotypes, C

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Familial fibrosing frontal alopecia in six sisters

Cited by 4 publications

References 4 publications

Frontal Fibrosing Alopecia: Is There a Link in Relatives?

Frontal Fibrosing Alopecia: Is There a Link in Relatives?

Familial Frontal Fibrosing Alopecia

A large familial cluster and sporadic cases of frontal fibrosing alopecia in Brazil reinforce known human leucocyte antigen (HLA) associations and indicate new HLA susceptibility haplotypes

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