Eruptive disseminated Spitz nevi – Case report

Vargas, Pablo; Cárdenas, Rodrigo A.; Cullen, Roberto; Figueroa, Andrés

doi:10.1016/j.abd.2019.01.010

Cited by 5 publications

(6 citation statements)

References 9 publications

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“…Several EDSN have presented in a symmetric distribution. 4,12,22,25,29 According to some, this pattern suggest a vascular dissemination, 29 with a cutaneous tropism similar to the ascending embryologic pattern of melanocytic migration to the skin. 29 This latter point, however, is not exclusive of tropism to other internal organs, obviously not investigated.…”

Section: Case Reportmentioning

confidence: 98%

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Genetic Studies on a Case of Eruptive Disseminated Spitz Nevus and Review of Other 33 Cases

Fernández-Flores

Cassarino

2022

The American Journal of Dermatopathology

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Eruptive disseminated Spitz nevus is an uncommon presentation of Spitz nevi. Only a few tens of cases have been published and only 6 of them have genetic studies. We present an additional case of a 29-year-old woman with dozens of Spitz nevi which had appeared since she was aged 10 years. The nevi were located on arms, inner thighs, legs, and buttocks. Nine of them were biopsied. Four presented severe atypia. Immunohistochemistry was performed on 5 of the biopsied specimens and was negative for PRAME, ROS-1, PDL-1, pan-TRK, and ALK. Molecular studies on the largest lesion demonstrated no NTRK1, NTRK2, or NTRK3 fusions. FISH study for PTEN showed no alteration in that same lesion. Next-generation sequencing was also negative for any detectable mutations in numerous genes analyzed. In conclusion, it seems reasonable to be cautious when evaluating atypia, even if severe, in cases of eruptive disseminated Spitz nevus.

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Section: Case Reportmentioning

confidence: 98%

“…57 In several cases, EDSN spontaneously regressed. 3,4,7,31 Lymphocyte-mediated regression (different to involution due to senescence) is not an uncommon phenomenon in Spitz nevi, 59 although it usually takes months or years, [60][61][62] and it is not necessarily complete. It happens in some degree in up to 79% of cases of Spitz nevus.…”

Section: Case Reportmentioning

confidence: 99%

Genetic Studies on a Case of Eruptive Disseminated Spitz Nevus and Review of Other 33 Cases

Fernández-Flores

Cassarino

2022

The American Journal of Dermatopathology

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“…Although our solution Fig. 2 Examples of division into superpixels by LIME and by our algorithm of skin lesion (Vargas et al, 2020) and car photo. For each pair, the left image shows the automatic LIME segmentation and the right one a LIMEcraft segmentation supported by the user who outlined the skin lesion of interest (first pair) or the car (second pair).…”

Section: Motivationmentioning

confidence: 99%

LIMEcraft: handcrafted superpixel selection and inspection for Visual eXplanations

2022

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The increased interest in deep learning applications, and their hard-to-detect biases result in the need to validate and explain complex models. However, current explanation methods are limited as far as both the explanation of the reasoning process and prediction results are concerned. They usually only show the location in the image that was important for model prediction. The lack of possibility to interact with explanations makes it difficult to verify and understand exactly how the model works. This creates a significant risk when using the model. The risk is compounded by the fact that explanations do not take into account the semantic meaning of the explained objects. To escape from the trap of static and meaningless explanations, we propose a tool and a process called LIMEcraft. LIMEcraft enhances the process of explanation by allowing a user to interactively select semantically consistent areas and thoroughly examine the prediction for the image instance in case of many image features. Experiments on several models show that our tool improves model safety by inspecting model fairness for image pieces that may indicate model bias. The code is available at: http://github.com/MI2DataLab/LIMEcraft.

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“…The agminated form appears as localized clusters or segmental distributed speckles that often arise on a lentiginous patch. The disseminated variant is a less common manifestation, with only 28 reports in the literature, and consists of the eruption of scattered polymorphic papules throughout the body, in a short period of time 1 . First described as “eruptive juvenile melanomata”, this latter entity most frequently occurs between the second and third decade of life, with a slight predilection in women 2,3 .…”

Section: Figurementioning

confidence: 99%

“…The disseminated variant is a less common manifestation, with only 28 reports in the literature, and consists of the eruption of scattered polymorphic papules throughout the body, in a short period of time. 1 First described as "eruptive juvenile melanomata", this latter entity most frequently occurs between the second and third decade of life, with a slight predilection in women. 2,3 Its etiopathogenesis is still unknown; however, it has been related to trauma, radiotherapy, intravenous drugs, pregnancy, and other sorts of cutaneous stimulation.…”

Section: Given These Findings a Diagnosis Of Eruptive Disseminatedmentioning

confidence: 99%

Eruptive disseminated Spitz nevi: a case report

et al. 2020

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Eruptive disseminated Spitz nevi – Case report

Cited by 5 publications

References 9 publications

Genetic Studies on a Case of Eruptive Disseminated Spitz Nevus and Review of Other 33 Cases

Genetic Studies on a Case of Eruptive Disseminated Spitz Nevus and Review of Other 33 Cases

LIMEcraft: handcrafted superpixel selection and inspection for Visual eXplanations

Eruptive disseminated Spitz nevi: a case report

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