volume 91, issue 3, P631-639 2015
DOI: 10.1016/j.ijrobp.2014.11.004
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Lauren E. Colbert, Sarah B. Fisher, Serdar Balci, Burcu Saka, Zhengjia Chen, Sungjin Kim, Bassel F. El-Rayes, N. Volkan Adsay, Shishir K. Maithel, Jerome C. Landry, Walter J. Curran

Abstract: Purpose Nuclear Hypoxia-Inducible Factor 1 Alpha (HIF1a) is involved in tumor response to microenvironmental stress and may initiate development of micrometastases and chemoradiation resistance. The goal of this analysis was to evaluate HIF1a expression as a prognostic factor for distant recurrence (DR) and local recurrence (LR) following pancreatic adenocarcinoma (PAC) resection. Materials/Methods Tissue specimens were collected from 98 patients with PAC who underwent resection without neoadjuvant therapy…

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