Imaging of Kaposi sarcoma

Addula, Dhivya; Das, Chandan Jyoti; Kundra, Vikas

doi:10.1007/s00261-021-03205-6

Cited by 13 publications

(3 citation statements)

References 57 publications

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“…Likewise, direct endoscopic visualization and sampling of the GI mucosa should be performed if other lesions are suspected due to the potential progression of KS. 15,16 One year after diagnosis, our patient remains disease-free after resection of the rectal nodule.…”

Section: Discussionmentioning

confidence: 84%

Gastrointestinal Kaposi Sarcoma: A Rare Case of an Isolated Rectal Lesion in an Immunocompetent HIV-Negative Patient

Silva-Santisteban,

Mahmood,

Fernandez

et al. 2023

ACG Case Rep J

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Kaposi sarcoma (KS) is a pathological endothelial growth associated with human herpes virus-8 which primarily affects the skin. In HIV-negative men who have sex with men, the clinical presentation of KS resembles the classic form limited to cutaneous or multifocal disease. In this report, we present a unique case of a healthy 61-year-old man who has sex with men with an isolated gastrointestinal KS who does not meet criteria for any of the typical KS clinical variants. Proper follow-up and regular HIV screenings are needed to evaluate the potential progression course of the disease in these patients.

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Section: Discussionmentioning

confidence: 84%

Gastrointestinal Kaposi Sarcoma: A Rare Case of an Isolated Rectal Lesion in an Immunocompetent HIV-Negative Patient

Silva-Santisteban,

Mahmood,

Fernandez

et al. 2023

ACG Case Rep J

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“…Pulmonary involvement is particularly important, as it is associated with worse prognosis and increased mortality compared with other systems [ 7 ]. In a cohort of 305 HIV-1-infected patients diagnosed with KS since 1996, the median survival time for patients with pulmonary KS was 19 months compared with a median survival time of four months reported for the same cohort in the pre-ART era [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

Kaposi Sarcoma as Presentation of HIV – A Clinical Case

Costa¹,

Silva²,

Monteiro³

et al. 2021

Cureus

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Kaposi sarcoma (KS) is the most common neoplasm of people with human immunodeficiency virus (HIV) infection. Although, in the antiretroviral therapy (ART) era, KS is a rare form of presentation of HIV/acquired immunodeficiency syndrome. The authors present a case of disseminated KS in a 23-year-old male. Just after the diagnosis the patient started ART and then chemotherapy with placlitaxel with clinical improvement. This case is highly representative of the complexity of HIV. The authors aim to bring awareness of an unusual form of presentation of HIV, and recall the severity and the necessity of an early diagnosis and treatment.

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“…No current guidelines recommend the use of virological diagnosis tools to detect the HHV-8 genome or antibodies for KS diagnosis, but HHV-8 can be identified by using LNA-1 antibody or by PCR. Imaging using modalities such as CT, MRI, and FDG-PET/CT scans can aid in diagnosing and staging cutaneous KS and lymph node involvement, as well as responses to treatment of KS lesions [ 77 , 78 ].…”

Section: Clinical Presentations Of Ks-irismentioning

confidence: 99%

Immune Reconstitution Inflammatory Syndrome Associated Kaposi Sarcoma

Poizot‐Martin

Brégigeon

Palich

et al. 2022

Cancers

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People living with HIV (PLWH) with advanced immunosuppression who initiate antiretroviral therapy (ART) are susceptible to the occurrence of an immune reconstitution inflammatory syndrome (IRIS). Although ART is responsible for AIDS- associated Kaposi sarcoma (KS) improvement and resolution, new onset (unmasking KS-IRIS) or sudden progression of preexisting KS (paradoxical KS-IRIS) can occur after a time delay of between a few days and 6 months after the initiation or resumption of ART, even in patients with a low degree of immunocompromise. KS-IRIS incidence varies from 2.4% to 39%, depending on study design, populations, and geographic regions. Risk factors for developing KS-IRIS include advanced KS tumor stage (T1), pre-treatment HIV viral load >5 log10 copies/mL, detectable pre-treatment plasma-KSHV, and initiation of ART alone without concurrent chemotherapy. Both paradoxical and unmasking KS-IRIS have been associated with significant morbidity and mortality, and thrombocytopenia (<100,000 platelets/mm3 at 12 weeks) has been associated with death. KS-IRIS is not to be considered as ART failure, and an ART regimen must be pursued. Systemic chemotherapy for KS in conjunction with ART is recommended and, in contrast with management of IRIS for other opportunistic infections, glucocorticoids are contra-indicated. Despite our preliminary results, the place of targeted therapies in the prevention or treatment of KS-IRIS needs further assessment.

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Imaging of Kaposi sarcoma

Cited by 13 publications

References 57 publications

Gastrointestinal Kaposi Sarcoma: A Rare Case of an Isolated Rectal Lesion in an Immunocompetent HIV-Negative Patient

Gastrointestinal Kaposi Sarcoma: A Rare Case of an Isolated Rectal Lesion in an Immunocompetent HIV-Negative Patient

Kaposi Sarcoma as Presentation of HIV – A Clinical Case

Immune Reconstitution Inflammatory Syndrome Associated Kaposi Sarcoma

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