History of N-Acetylcysteine

Herzenberg, Leonore A.

doi:10.1007/978-981-10-5311-5_1

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…Changes in the redox status, including an increase in the level of ROS or a decrease in endogenous antioxidant levels, refer to a pathological state observed in several psychiatric and neurological disorders (Herzenberg, 2019; Smaga et al, 2012). In fact, the brain is uniquely vulnerable to ROS due to its high oxygen metabolism and limited antioxidant capabilities.…”

Section: Mechanism Of Actionmentioning

confidence: 99%

“…First, NAC has been widely prescribed as a mucolytic agent for patients with cystic fibrosis and as an antidote to treat paracetamol overdose. The therapeutic potential of NAC has also been used to prevent liver diseases associated with decreased GSH levels and/or increased oxidative stress, such as alcoholic liver disease (Herzenberg, 2019). NAC is considered safe and well tolerated for most children and adults when administered orally, intravenously, or via inhalation.…”

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confidence: 99%

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N‐acetylcysteine as a new prominent approach for treating psychiatric disorders

Smaga

Frankowska

Filip

2021

British J Pharmacology

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N‐acetylcysteine (NAC) is a well‐known and safe mucolytic agent, also used in patients with paracetamol overdose. In addition to these effects, recent preclinical and clinical studies have shown that NAC exerts beneficial effects on different psychiatric disorders. Many potential mechanisms have been proposed to underlie the therapeutic effects of NAC, including the regulation of several neurotransmitters, oxidative homeostasis, and inflammatory mediators. In this paper, we summarize the current knowledge on the ability of NAC to ameliorate symptoms and neuropathologies related to different psychiatric disorders, including attention deficit hyperactivity disorder, anxiety, bipolar disorder, depression, obsessive–compulsive disorder, obsessive–compulsive‐related disorder, posttraumatic stress disorder, and schizophrenia. Although preclinical studies have shown a positive effect of NAC on animal models of psychiatric disorders, the clinical efficacy of NAC is not fully established. NAC remains a strong candidate for adjunct treatment for many psychiatric disorders, but additional preclinical and clinical studies are needed.

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Section: Mechanism Of Actionmentioning

confidence: 99%

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confidence: 99%

N‐acetylcysteine as a new prominent approach for treating psychiatric disorders

Smaga

Frankowska

Filip

2021

British J Pharmacology

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Protective effects of jervine purified from Veratrum album on paracetamol-induced liver toxicity in rats

Yiğit,

Aydın,

Bitiktaş

et al. 2024

Cukurova Medical Journal

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Purpose: Since paracetamol toxicity is a very common type of poisoning, we planned to investigate whether Jervine has an effect on paracetamol toxicity by utilizing its anti-inflammatory effect. Materials and Methods: In our study, 42 Sprague Dawley rats of 8 weeks of age were used. Seven groups were formed with 6 animals in each group. At the 24th hour of the study, all groups underwent laparotomy under anesthesia, and liver dissection was performed. Hematoxylin and Eosin (H&E) staining was performed to evaluate liver histopathology. SOD, CAT, GSH, and MDA levels were analyzed biochemically. Results: Histopathological, while liver tissues were normal in the control group, we observed degeneration areas, inflammation, and hemorrhage in the paracetamol group. Jervine reduced the severity of paracetamol toxicity and prevented liver damage. Jervine significantly increased SOD levels. Paracetamol administration significantly decreased CAT levels. Paracetamol significantly decreased GSH levels compared to the control group. Conclusion: Jervine reduced the adverse effects of paracetamol toxicity on liver tissue, such as degeneration, inflammation, and hemorrhage. Jervine increased antioxidant activity and reduced the harmful effects of NAPQI, the toxic metabolite of paracetamol, on liver tissue.

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History of N-Acetylcysteine

Cited by 2 publications

References 11 publications

N‐acetylcysteine as a new prominent approach for treating psychiatric disorders

N‐acetylcysteine as a new prominent approach for treating psychiatric disorders

Protective effects of jervine purified from Veratrum album on paracetamol-induced liver toxicity in rats

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