Asbestos-Induced Oxidative Stress in Lung Pathogenesis

Miller, J; Thompson, Joyce K.; Shukla, Arti

doi:10.1007/978-3-642-30018-9_201

Cited by 2 publications

(2 citation statements)

References 107 publications

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“…Pulmonary fibrosis is a well-studied human disease and the cumulative number of publications between 1975 and 2010 reached beyond 17 000 papers, as reviewed by Todd et al (2012), citing over 300 papers. We focused our search for general schemes of pulmonary fibrosis development and progression to recent reviews, including Todd et al (2012), as well as 6 other reviews (Boyles et al, 2014;Kinnula et al, 2005;Manresa et al, 2014;Miller et al, 2014;Rockey et al, 2015;Vancheri, 2013). In addition, 2 reviews relevant to AOP development for pulmonary fibrosis were identified (Labib et al 2015;Vietti et al 2016).…”

Section: Methodsmentioning

confidence: 99%

A Data Fusion Pipeline for Generating and Enriching Adverse Outcome Pathway Descriptions

Nymark

Rieswijk

Ehrhart

et al. 2017

Toxicological Sciences

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Increasing amounts of systems toxicology data, including omics results, are becoming publically available and accessible in databases. Data-driven and informatics-tool supported pipeline schemas for fitting such data into Adverse Outcome Pathway (AOP) descriptions could potentially aid the development of nonanimal-based hazard and risk assessment methods. We devised a 6-step workflow that integrated diverse types of toxicology data into a novel AOP scheme for pulmonary fibrosis. Mining of literature references and diverse data sources covering previous pathway descriptions and molecular results were coupled in a stepwise manner with informatics tools applications that enabled gene linkage and pathway identification in molecular interaction maps. Ultimately, a network of functional elements coupled 64 pulmonary fibrosis-associated genes into a novel, open-source AOP-linked molecular pathway, now available for commenting and improvements in WikiPathways (WP3624). Applying in silico-based knowledge extraction and modeling, the pipeline enabled screening and fusion of many different complex data types, including the integration of omics results. Overall, the taken, stepwise approach should be generally useful to construct novel AOP descriptions as well as to enrich developing AOP descriptions in progress.

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Section: Methodsmentioning

confidence: 99%

A Data Fusion Pipeline for Generating and Enriching Adverse Outcome Pathway Descriptions

Nymark

Rieswijk

Ehrhart

et al. 2017

Toxicological Sciences

View full text Add to dashboard Cite

show abstract

“… The “oxidative stress theory” explains that an indirect action of asbestos, due to the inability of phagocytic cells to digest asbestos fibers, results in a massive release of reactive oxygen species and reactive nitrogen from macrophages (Fig. 1 ), thus causing chronic inflammation [ 31 , 32 ]. Consequently, oxidative stress impairs DNA repair mechanisms [ 33 , 34 ] and leads to genetic and epigenetic alterations responsible for uncontrolled growth, resistance to apoptosis, and ultimately the occurrence of MPM [ 33 , 35 , 36 ].…”

Section: Cellular Processes and Molecular Alterations Leading To Mpmmentioning

confidence: 99%

Molecular Alterations in Malignant Pleural Mesothelioma: A Hope for Effective Treatment by Targeting YAP

et al. 2022

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Malignant pleural mesothelioma is a rare and aggressive neoplasm, which has primarily been attributed to the exposure to asbestos fibers (83% of cases); yet, despite a ban of using asbestos in many countries, the incidence of malignant pleural mesothelioma failed to decline worldwide. While little progress has been made in malignant pleural mesothelioma diagnosis, bevacizumab at first, then followed by double immunotherapy (nivolumab plus ipilumumab), were all shown to improve survival in large phase III randomized trials. The morphological analysis of the histological subtyping remains the primary indicator for therapeutic decision making at an advanced disease stage, while a platinum-based chemotherapy regimen combined with pemetrexed, either with or without bevacizumab, is still the main treatment option. Consequently, malignant pleural mesothelioma still represents a significant health concern owing to poor median survival (12–18 months). Given this context, both diagnosis and therapy improvements require better knowledge of the molecular mechanisms underlying malignant pleural mesothelioma’s carcinogenesis and progression. Hence, the Hippo pathway in malignant pleural mesothelioma initiation and progression has recently received increasing attention, as the aberrant expression of its core components may be closely related to patient prognosis. The purpose of this review was to provide a critical analysis of our current knowledge on these topics, the main focus being on the available evidence concerning the role of each Hippo pathway’s member as a promising biomarker, enabling detection of the disease at earlier stages and thus improving prognosis.

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Asbestos-Induced Oxidative Stress in Lung Pathogenesis

Cited by 2 publications

References 107 publications

A Data Fusion Pipeline for Generating and Enriching Adverse Outcome Pathway Descriptions

A Data Fusion Pipeline for Generating and Enriching Adverse Outcome Pathway Descriptions

Molecular Alterations in Malignant Pleural Mesothelioma: A Hope for Effective Treatment by Targeting YAP

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