Health Hazards Associated with Wheat and Gluten Consumption in Susceptible Individuals and Status of Research on Dietary Therapies

Rustgi, Sachin; Shewry, Peter R.; Brouns, Fred

doi:10.1007/978-3-030-34163-3_20

Cited by 4 publications

(4 citation statements)

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“…In susceptible individuals, many indigestible peptides were identified to trigger immune responses, such as celiac disease, wheat allergy, and non-celiac wheat sensitivity ( 2 ). No therapy other than a restrictive diet is available, which is not a straightforward solution due to the ubiquity of gluten proteins in processed foods, medicines, and cosmetics, unintended contaminations, and fiscal/social reasons ( 47 ). Hence a broadly acceptable solution to this problem is sorely needed.…”

Section: Discussionmentioning

confidence: 99%

Targeting Induced Local Lesions in the Wheat DEMETER and DRE2 Genes, Responsible for Transcriptional Derepression of Wheat Gluten Proteins in the Developing Endosperm

et al. 2022

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Wheat is a major source of energy and nutrition worldwide, but it is also a primary cause of frequent diet-induced health issues, specifically celiac disease, for which the only effective therapy so far is strict dietary abstinence from gluten-containing grains. Wheat gluten proteins are grouped into two major categories: high-molecular-weight glutenin subunits (HMWgs), vital for mixing and baking properties, and gliadins plus low-molecular-weight glutenin subunits (LMWgs) that contain the overwhelming majority of celiac-causing epitopes. We put forth a hypothesis that eliminating gliadins and LMWgs while retaining HMWgs might allow the development of reduced-immunogenicity wheat genotypes relevant to most gluten-sensitive individuals. This hypothesis stems from the knowledge that the molecular structures and regulatory mechanisms of the genes encoding the two groups of gluten proteins are quite different, and blocking one group's transcription, without affecting the other's, is possible. The genes for gliadins and LMWgs have to be de-methylated by 5-methylcytosine DNA glycosylase/lyase (DEMETER) and an iron-sulfur (Fe-S) cluster biogenesis enzyme (DRE2) early during endosperm development to permit their transcription. In this study, a TILLING (Targeting Induced Local Lesions IN Genomes) approach was undertaken to identify mutations in the homoeologous DEMETER (DME) and DRE2 genes in common and durum wheat. Lines with mutations in these genes were obtained that displayed reduced content of immunogenic gluten proteins while retaining essential baking properties. Although our data at first glance suggest new possibilities for treating celiac disease and are therefore of medical and agronomical interest, it also shows that inducing mutations in the DME and DRE2 genes analyzed here affected pollen viability and germination. Hence there is a need to develop other approaches in the future to overcome this undesired effect.

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Section: Discussionmentioning

confidence: 99%

Targeting Induced Local Lesions in the Wheat DEMETER and DRE2 Genes, Responsible for Transcriptional Derepression of Wheat Gluten Proteins in the Developing Endosperm

et al. 2022

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“…No extant wheat genotype under cultivation or in the wild is safe for celiac patients [9,27,28]. in order to develop celiac-safe wheat cultivars, we undertook two approaches: genetic engineering and germplasm screening.…”

Section: Peanut Genetic Engineering For Reduced Content Of Immunogeni...mentioning

confidence: 99%

“…Similar efforts are underway in different parts of the world to develop reducedimmunogenicity wheat genotypes suitable for celiac patients and wheat-allergic individuals [9,27,28,39]. Some noteworthy efforts from the public sector were from Francisco Barro's group at the Institute for Sustainable Agriculture, Córdoba, Spain; Susan Altenbach's group at the Western Regional Research Center, USDA-ARS, Albany, CA, USA; Hetty van den Broeck's group and Marinus Smulders's group at Wageningen University & Research, The Netherlands; and Domenico Lafiandra's group at the University of Tuscia, Italy.…”

Section: Wheat-germplasm Screening For Reduced-gluten Contentmentioning

confidence: 99%

Reduced-Immunogenicity Wheat and Peanut Lines for People with Foodborne Disorders

Rustgi

Alam²,

Jones³

et al. 2022

Iocag 2022

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“…In the absence of a cure for CD, prevention by following a strict, life-long glutenfree diet is the only remedy currently available. In practice this is a challenge for CD patients because of the presence of wheat and gluten in many food products as explained above (Gilissen et al 2014;Rustgi et al 2020). Indeed, compliance with the gluten-free diet is difficult and presently far from 100% (Scherf et al 2020).…”

Section: Negative Effects Of Wheat Consumptionmentioning

confidence: 99%

Low Gluten and Coeliac-Safe Wheat Through Gene Editing

Gilissen

Smulders

2021

Plant Biotechnology

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Article 25fa states that the author of a short scientific work funded either wholly or partially by Dutch public funds is entitled to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work.This publication is distributed under The Association of Universities in the Netherlands (VSNU) 'Article 25fa implementation' project. In this project research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication.

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Health Hazards Associated with Wheat and Gluten Consumption in Susceptible Individuals and Status of Research on Dietary Therapies

Cited by 4 publications

References 223 publications

Targeting Induced Local Lesions in the Wheat DEMETER and DRE2 Genes, Responsible for Transcriptional Derepression of Wheat Gluten Proteins in the Developing Endosperm

Targeting Induced Local Lesions in the Wheat DEMETER and DRE2 Genes, Responsible for Transcriptional Derepression of Wheat Gluten Proteins in the Developing Endosperm

Reduced-Immunogenicity Wheat and Peanut Lines for People with Foodborne Disorders

Low Gluten and Coeliac-Safe Wheat Through Gene Editing

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