Drug–Nutrient Interactions in the Elderly

Kinosian, Bruce; Knight-Klimas, Tanya C.

doi:10.1007/978-1-60327-362-6_22

Cited by 1 publication

(1 citation statement)

References 214 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interactions between calcium ions and drugs such as tetracyclines and some fluoroquinolones are well known, where calcium forms insoluble complexes with these drugs, and thus negatively impacts their absorption. 1 Much less effort has been diverted to examine the potential of calcium interacting with different excipients, even though many excipients are anionic polymers, and thus capable of interacting with divalent cations such as calcium. Enteric film formers are one example of anionic polymers used as pharmaceutical excipients.…”

Section: Introductionmentioning

confidence: 99%

Effect of Calcium Ions on the Disintegration of Enteric-Coated Solid Dosage Forms

Al-Gousous

Langguth

2016

Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

To investigate the effect of calcium ions on the disintegration of enteric-coated dosage forms, disintegration testing was performed on enteric-coated aspirin tablets in the presence and absence of calcium in the test media. The results show that the presence of calcium ions retards the disintegration of enteric-coated dosage forms. This finding, which has not been reported in scientific literature, sheds light on the importance of conducting well-designed detailed investigations into the potential of calcium from dietary sources, calcium supplements, antacids, and/or phosphate binders affecting the absorption of drugs formulated into enteric-coated dosage forms. Moreover, it shows the necessity to investigate the potential of the occurrence of additional nutrient-excipient interactions.

show abstract

Section: Introductionmentioning

confidence: 99%