Papillary Microcarcinoma of the Thyroid

Drucker, William D.; Robbins, Richard J.

doi:10.1007/1-84628-013-3_29

Cited by 3 publications

(3 citation statements)

References 69 publications

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“…A consensus has been reached that, when PMCT is incidentally detected pathologically in surgical specimens of benign thyroid diseases, patients should generally be monitored without any surgery, such as complete total thyroidectomy with lymph node dissection. 27 Furthermore, as described above, the prevalence of incidentally detected PMCT and that of clinical thyroid carcinoma differ substantially. These findings strongly suggest that only a small number of PMCT grow, indicating that most tumors do not require surgical treatment.Whether an individual PMCT will remain latent or grow to cause harm is, however, impossible to predict at the time of diagnosis.…”

Section: Observational Trial Of Incidentally Detected Pmctmentioning

confidence: 93%

A therapeutic strategy for incidentally detected papillary microcarcinoma of the thyroid

2007

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Papillary microcarcinoma of the thyroid (PMCT) is defined as papillary carcinoma measuring 1.0 cm or less. PCMT are frequently detected by ultrasonographic screening and ultrasonography-guided fine-needle aspiration biopsy. Although PMCT can pathologically show a high incidence of multifocality and lymph node metastasis in surgical specimens, most tumors grow slowly or not at all when they are monitored without surgery. In our observations only 6.7% of PMCT enlarged by 3.0 mm or more in diameter during 5 years of follow-up, and nodal metastases became detectable in 1.7% of patients overall. Observation without surgery could, therefore, be an attractive alternative for patients with low-risk PMCT; however, occult PMCT, which are diagnosed as the origin of lymph node or distant metastasis, show a worse prognosis. Even among incidentally detected PMCT, tumors with ultrasonographically detectable nodal metastasis are more likely to recur. Because such PMCT are most likely to recur in the regional lymph nodes, careful therapeutic neck dissection and total thyroidectomy are required. For incidentally detected and low-risk PMCT, careful observation without surgery might be acceptable, but careful and systematic surgery should be performed for patients with PMCT demonstrating aggressive characteristics.

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Section: Observational Trial Of Incidentally Detected Pmctmentioning

confidence: 93%

A therapeutic strategy for incidentally detected papillary microcarcinoma of the thyroid

2007

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“…Вивчаються різні питання особливостей клінічного перебігу мультифокальної папілярної карциноми. У фаховій літературі приділяється особлива увага мультифокальності як фактору ризику появи метастазів у лімфатичних вузлах [14,20], прогнозу одужання [16], рецидиву хвороби [6,12] та більш агресивних ознак пухлини [10,11]. Автори роботи [5] дійшли висновку, що мультифокальний папілярний рак ЩЗ є більш агресивним, ніж одиничне пошкодження.…”

Section: медична інформатика медична інформатика та інженеріяunclassified

“…Але, хоча і в меншості, існують дані щодо відсутності достовірної різниці між моно-та мультифокальними карциномами [1,7]. Здебільшого в роботах на основі ґрунтовних та об'ємних досліджень висловлюється думка щодо достовірного впливу на прогноз мультифокаль-них пухлин розміром понад 1 см, тоді як менші не мають такого достовірного впливу [2,6,18,19].…”

Section: медична інформатика медична інформатика та інженеріяunclassified

Оцінка Прогнозу Мультифокальної Високодиференційованої Тиреоїдної Карциноми За Системою TNM

Kobrynska¹

2016

MIE

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The comparative analysis of mono- and multifocal highly differentiated thyroid carcinoma (papillary and follicular) according to the TNM system was conducted. There were analyzed 2208 cases of monofocal and 692 cases of multifocal lesions in total. The analysis demonstrated that multifocal carcinomas, unlike solitary lesions, were characterized by a more aggressive course. Multicenter lesion by rubrics T, N and M with certainty at 99 % and more had higher indices than monofocal. Thus, T2 stage was recorded at 20.4 % of multifocal carcinomas versus 15.7 % for monofocal. The difference in T3 stage was also significant (22.4 % vs. 18.8 % respectively). In cases of T4 stage percent difference was 6.9 % with 5.0 % of multifocal and monofocal with thyroid carcinomas. N1a stage was recorded in 16.2 % of cases of multifocal carcinomas compared with 13.7 % for monofocal. Even more significant was the difference in N1b category - 15.7 % among multifocal that only 8.7 % of monofocal thyroid carcinomas. Distant metastases in patients with mono- and multifocal carcinoma were detected in isolated cases and this group of patients did not differ significantly from one another in such case (p > 0.05). The main conclusion is the need for more radical tactics of treatment in these cases.

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Papillary thyroid microcarcinoma: incidence and prognostic factors

Jacquot-Laperrière

Timoshenko

Dumollard

et al. 2007

Eur Arch Otorhinolaryngol

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The objective of this study was to define the prognostic factors of papillary microcarcinoma of the thyroid (PMCT), and to analyse their epidemiologic and histopathologic characteristics. Our series included 57 patients diagnosed with PMCT between 1994 and 2003 among 944 patients who underwent thyroid surgery. All the surgical specimens were examined in the same department of pathology using the same technique. The prognostic factors were elaborated from the results of the histological examination. The epidemiological and histopathological characteristics were also evaluated. Two sub-groups were distinguished: patients with node disease and/or with metastasis (17 patients) and patients without node disease and metastasis (40 patients). The architecture of PMCT was papillary in 14% of cases, follicular in 35% of cases and mixed in 49% of cases, with no significant difference between any two groups. Histopathologic characteristics such as the vascular extension, infiltration into the adjacent parenchyma or in the thyroid capsule are all indicative of a poor prognosis. Two categories of PMCT, with and without the risk of metastatic spread, can be identified from these prognostic factors.

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Papillary Microcarcinoma of the Thyroid

Cited by 3 publications

References 69 publications

A therapeutic strategy for incidentally detected papillary microcarcinoma of the thyroid

A therapeutic strategy for incidentally detected papillary microcarcinoma of the thyroid

Оцінка Прогнозу Мультифокальної Високодиференційованої Тиреоїдної Карциноми За Системою TNM

Papillary thyroid microcarcinoma: incidence and prognostic factors

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