Carbon‐Nanotube Shape and Individualization Critical for Renal Excretion

Lacerda, Lara; Herrero, M. Antonia; Venner, Kerrie; Bianco, Alberto; Prato, Maurizio; Kostarelos, Kostas

doi:10.1002/smll.200800323

Cited by 163 publications

(136 citation statements)

References 18 publications

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“…The detailed size distributions (Figure 3) indicate that agglomeration tendency in pBALF is still significantly stronger than in Fetal Calf Serum (FCS; Figure 3), which is widely used in cell culture media. Several studies have hinted at the dispersing power of albumin and other interface-active serum components on CNTs [32][33][34], metal carbide nanoparticles [35,36] and metal oxide nanoparticles [1,[35][36][37][38]. For mouse BALF, the degree of agglomeration of metal oxide nanoparticles was reported to be comparable with a buffer containing BSA and dipalmitoyl phosphatidyl choline [39] and in a BAL-mimicking dispersion medium [40], but only after 10 min.…”

Section: Investigation Of Deagglomeration Capacity Of Pbalfmentioning

confidence: 99%

Interaction of metal oxide nanoparticles with lung surfactant protein A

Schulze

Schaefer

Ruge

et al. 2011

European Journal of Pharmaceutics and Biopharmaceutics

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Section: Investigation Of Deagglomeration Capacity Of Pbalfmentioning

confidence: 99%

Interaction of metal oxide nanoparticles with lung surfactant protein A

Schulze

Schaefer

Ruge

et al. 2011

European Journal of Pharmaceutics and Biopharmaceutics

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“…This biodistribution and excretion pattern was confirmed by 56 Advanced Bioceramics in Nanomedicine and Tissue Engineering others [12,13]. SWNTs and MWNTs functionalized with the chelating molecule diethylentriaminepentaacetic (DTPA) and labeled with 111 In was evaluated in mice after IV injection [12].…”

Section: T Size Type and Structure-related Propertiesmentioning

confidence: 75%

“…The main excretion pathway was through the kidneys in the urine and no accumulation in the liver was observed. Clearance from the blood was rapid, with a t½ =3 h. Lacerda et al [13] Nanotube defects may also be common in CNT raw materials. During purification of CNTs, strong acid treatment oxidative reactions form carboxyl residues at the ends or at the sides of the nanotubes.…”

Section: T Size Type and Structure-related Propertiesmentioning

confidence: 99%

Formulating Nanomedicines: Focus on Carbon Nanotubes as Novel Nanoexcipients

Földvári

2010

KEM

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Many recently designed drug delivery systems have been constructed from nano-sized components that serve as the carrier or targeting ligand for a therapeutic agent. Even though these materials have been regarded previously as inert or non-active components of dosage forms, they are now recognized as sometimes being even more important than the drug itself. Hence, it is becoming increasingly imperative that the pharmaceutically relevant properties, including identity, physicochemical characteristics, purity, solubility and toxicity, of these functional nano-excipients be fully characterized. Carbon nanotubes (CNTs) are novel nanomaterials made of carbon atoms that have wide application potential in many areas of nanomedicine. However, because of their significant potential, CNTs, as building blocks for nanomedicines, need to be characterized more fully. Studies to date indicate that both physical and chemical properties of CNTs play an important role in their interactions with cells. Therefore, a full understanding of the physical properties of CNTs, such as identity, chirality, particle size, aspect ratio, morphology and dispersion state, as well as chemical properties such as purity, defect sites and types and functional groups, will be essential to develop a full characterization panel of these versatile nanomaterials.

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“…The blood circulation half-lives of current CNT carriers range from 0.5 to 3.5 h in mice [3,6,30], which are significantly shorter than that of PEG-grafted liposomes (12 20 h in rats or mice, and 40 60 h in humans) [31]. While some reports have shown renal excretion of certain CNTs [6,32,33], there have also been others showing accumulation in organs such as liver, spleen, and kidney [3,30,34]. Although no acute or short mid term (up to four months) cytotoxic effects on the organs or the test subjects have been reported so far, the long term toxicity and immunogenicity of CNT carriers are unclear.…”

Section: Discussionmentioning

confidence: 99%

Carbon nanotubes inhibit the hemolytic activity of the pore-forming toxin pyolysin

Donkor

Mandal

et al. 2009

Nano Res.

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Functionalized carbon nanotubes have already demonstrated great biocompatibility and potential for drug delivery. We have synthesized acid oxidized and non-covalently PEGlyated single-walled carbon nanotubes (SWNTs), which were previously prepared for drug delivery purposes, and explored their potential for detoxifi cation in the bloodstream. Our investigations of the binding of SWNTs to a pore-forming toxin pyolysin show that SWNTs prevented toxin-induced pore formation in the cell membrane of human red blood cells. Quantitative hemolysis assay and scanning electron microscopy were used to evaluate the inhibition of hemolytic activity of pyolysin. According to Raman spectroscopy data, human red blood cells, unlike HeLa cells, did not internalize oxidized SWNTs. Molecular modeling and circular dichroism measurements were used to predict the 3-D structure of pyolysin (domain 4) and its interaction with SWNTs. The tryptophan-rich hydrophobic motif in the membrane-binding domain of pyolysin, a common construct in a large family of cholesterol-dependent cytolysins, shows high affi nity for SWNTs.

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Carbon‐Nanotube Shape and Individualization Critical for Renal Excretion

Abstract: Nanotube shape and the degree of individualization are found to play a critical role in their in vivo transport and translocation profile. Carbon nanotubes (see image) that are well individualized and soluble in biological milieu can cross the kidney barrier and be excreted in urine.

Cited by 163 publications

References 18 publications

Interaction of metal oxide nanoparticles with lung surfactant protein A

Interaction of metal oxide nanoparticles with lung surfactant protein A

Formulating Nanomedicines: Focus on Carbon Nanotubes as Novel Nanoexcipients

Carbon nanotubes inhibit the hemolytic activity of the pore-forming toxin pyolysin

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