Synthesis and properties of poly(2,5‐thienylene)

Lin, John W. P.; Dudek, Lesley P.

doi:10.1002/pol.1980.170180910

Cited by 179 publications

(74 citation statements)

References 10 publications

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“…Chemical synthesis of unsubstituted polythiophenes was first described in the 1980s of Yamamoto and Lin [11,12]. They both used 2,5-dibromothiophene in a metal-catalyzed polycondensation polymerization.…”

Section: Conjugated Thiophenes a Historical Viewmentioning

confidence: 99%

Asymmetric Oligothiophenes : Chemical Evolution of Multimodal Amyloid Ligands

Johansson

2015

Linköping Studies in Science and Technology. Dissertations

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Luminescent conjugated polymers (LCPs) and luminescent conjugated oligothiophenes (LCOs) can be used as molecular probes to study diseases associated with protein aggregation. The conventionally used dyes to study and detect protein aggregates, denoted amyloid, have been Congo red (CR) and Thioflavin T (ThT). In contrast to these amyloid ligands, LCOs offer the possibility to detect aggregated proteinaceous species occurring at earlier stages of amyloid formation as well as to distinguish different morphotypes of protein aggregates. The interaction between the LCOs and the protein deposits can be studied by fluorescence spectroscopy and microscopy both in vitro and ex vivo. In this thesis we report the development of multimodal asymmetric LCOs that can be utilized with two novel techniques, Surface Plasmon Resonance (SPR) and Positron Emission Tomography (PET), to study and visualize the interaction between LCO and amyloid fibrils in real time. With SPR, we have been able to determine binding affinities between LCO and amyloid, and with PET we have shown that radiolabelled LCOs might be used as a non-invasive method to study amyloid deposits in vivo. In addition, by alteration of the backbone (change of thiophene units), and of adding different side chain functionalities, we have shown that the properties of the amyloid ligands have a huge impact of the binding to different stages or forms of protein aggregates. By making asymmetrical LCOs, which can be attached to a surface, we also foresee a methodology that will offer the possibility to create a sensitive and selective detection method, and maybe lead to a lab-on-a-chip-application. VIII IX POPULÄRVETENSKAPLIG SAMMANFATTNINGTidigare arbete i Peter Nilssons forskargrupp har visat att luminiscenta konjugerade polymerer (LCPs) och luminiscenta konjugerade oligotiofener (LCOs) kan användas som molekylära prober för att studera sjukdomar associerade till protein aggregering. De konventionellt använda markörerna för att studera och detektera proteinaggregat, så kallad amyloid, är Kongorött (CR) och Thioflavin T (ThT). I kontrast till dessa konventionella markörer har Nilssons forskargrupp visat att LCOs, på grund av deras flexibla konjugerade struktur, och laddning kan upptäcka både tidigare stadier av proteinaggregat samt också skilja på olika typer av aggregat. När LCO interagerar med proteinaggregaten kan denna interaktion studeras med fluorescens mikroskopi både in vitro och ex vivo. Arbetet i den här avhandlingen beskriver utvecklingen av amyloidligander från polymera till osymmetriska material samt två nya tekniker för att studera interaktionen mellan LCO och amyloida fibrer i realtid, Surface Plasmon Resonance (SPR) och Positron Emission Tomography (PET). Med SPR har vi kunnat bestämma bindingsaffiniteter mellan LCO och amyloida fibrer, och med PET har vi visat att radioinmärkta LCOs kan användas som en icke-invasiv metod för att studera amyloid in vivo. Under min forskarutbildning har jag syntetiserat och karaktäriserat både symmetriska och osymmetr...

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Section: Conjugated Thiophenes a Historical Viewmentioning

confidence: 99%

Asymmetric Oligothiophenes : Chemical Evolution of Multimodal Amyloid Ligands

Johansson

2015

Linköping Studies in Science and Technology. Dissertations

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“…The merit of our polymers is that the conjugated polymer main chains consist only of stable aromatic portions. However, their PL peaks in the film states were observed at around 480 nm with a broad shoulder band at about 520 nm tailing to 600 nm, which were considerably longer in wavelength compared with those in CHCl 3 , and the color of PL was green-blue. This redshift is mainly due to specific p-stacks of naphthalene portions and excimeric emissions caused by strong interaction between the polymer main chains.…”

Section: Introductionmentioning

confidence: 95%

Synthesis and optical properties of blue luminescent poly(2,6‐naphthalene)s

Mori

Kijima

2008

J. Polym. Sci. A Polym. Chem.

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“…Polythiophene (PTh) has been widely studied since the first reports of their synthesis in scientific literature [1,2]. Both environmental and thermal stability of this class of polymers granted in high potential application in different technical processes and products.…”

Section: Introductionmentioning

confidence: 99%

Emulsion Polymerization of Thiophene – The New Way of Conducting Polymers Synthesis

Nowaczyk¹,

Kadac²,

Olewnik-Kruszkowska³

2015

Adv. Sci. Technol. Res. J.

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The aim of this study was to investigate the new method of polythiophene polymerization. It was made an attempt of the chemical oxidation of thiophene in aqueous medium without the addition of any surfactant. The oxidative compound applied in the synthesis was gaseous ozone. Resulting polymer was obtained in the form of nanospheres dispersed in water. The method developed in this study allow to obtain the polythiophene nanoparticles. Further study is required to fully identify the resulting product properties in comparison with polymer obtained in other methods.

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Synthesis and properties of poly(2,5‐thienylene)

Cited by 179 publications

References 10 publications

Asymmetric Oligothiophenes : Chemical Evolution of Multimodal Amyloid Ligands

Asymmetric Oligothiophenes : Chemical Evolution of Multimodal Amyloid Ligands

Synthesis and optical properties of blue luminescent poly(2,6‐naphthalene)s

Emulsion Polymerization of Thiophene – The New Way of Conducting Polymers Synthesis

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