HAp@GO drug delivery vehicle with dual‐stimuli‐triggered drug release property and efficient synergistic therapy function against cancer

Abstract

Nanoscale hydroxyapatite (HAp) is an optimal candidate material in biomedical area for its good biocompatibility and bioactivity. In this study, HAp nanorods are prepared via hydrothermal method and combined with monolayered graphene oxide (GO). The obtained HAp@GO with excellent biocompatibility is revealed to have high drug loading capacity (698.7 μg/mg) for anticancer drug doxorubicin (DOX) and efficient photothermal conversion property. And the drug release property of DOX loaded HAp@GO (HAp@GO-DOX) is demonstrated to be controlled by pH and nearinfrared light, which is favorable for cancer therapy. in vitro studies on cancer therapy demonstrate that the combined treatment, compared with either chemotherapy or photothermal therapy alone, has better synergistic therapeutic effect. These findings prove the great potential application of the nanocomposites for cancer therapy. K E Y W O R D S drug delivery, graphene oxide, hydroxyapatite nanorods, photothermal conversion, synergistic therapy

Multifunctional Surface with Enhanced Angiogenesis for Improving Long-Term Osteogenic Fixation of Poly(ether ether ketone) Implants

“…In brief, sPEEK was first immersed in 0.01 mol/L Ni­(OH) 2 suspension with a pH of 11 and then treated by hydrothermal reaction at 180 °C for 6 h. Afterward, the Ni-decorated PEEK (sPEEK-Ni) was immersed in a mixed suspension containing 0.04 mol Ca­(NO 3 ) 2 ·4H 2 O, 0.0018 mol ethylenediaminetetraacetate (EDTA)-2Na, and 0.018 mol (NH 4 ) 2 HPO 4 in 200 mL of D.I. water according to earlier literature . The pH value of the mixture was adjusted to 11 using a 0.04 g/mL NaOH solution.…”

“…water according to earlier literature. 39 The pH value of the mixture was adjusted to 11 using a 0.04 g/mL NaOH solution. The resulting HA and Ni element cofunctionalized porous PEEK (sPEEK-Ni-HA) was attained after a hydrothermal procedure at 180 °C for 12 h. Besides, the only HA-modified sPEEK (sPEEK-HA) and the Ni-modified sPEEK were also prepared through single-step hydrothermal synthesis as control groups.…”

Linear maltodextrin polymer–folic acid modified graphene oxide nanoparticles for targeted delivery and pH/photothermal sensitive release of hydrophobic anticancer drugs in tumor cells

“…9(b)) cells. 41,42 Normal cells showed weak blue and weak red, and apoptotic cells had weak red and strong blue, where strong red and strong blue represented the necrotic cells. We could conclude from Fig.…”

Curiosidades e implicaciones tecnológicas de la hidroxiapatita sintética

“…Sin embargo, en algunas ocasiones, la HAp ha trabajado en conjunto con otros materiales, por ejemplo, el óxido de grafeno (GO). (Sang et al, 2019) promovieron la interacción de ambos materiales debido a su excelente biocompatibilidad y bioactividad. Su investigación se basó en la sinergia de la HAp y el GO como transportador de fármacos, utilizando doxorrubicina (DOX), un fármaco quimioterapéutico ampliamente empleado en el tratamiento de varios tipos de cáncer, incluidos cáncer de mama, pulmón, gástrico, ovario, tiroides y pediátrico.…”