ChemInform Abstract: Synthesis of Pteridines Derivatives from Different Heterocyclic Compounds

Ahmed, Sayed A.; Elghandour, Ahmed H.; Elgendy, Hussein S.

doi:10.1002/chin.201519330

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since most components with biological activity are produced from heterocyclic structures, the synthesis of heterocyclic systems is of continuous interest in the study of organic chemistry. A broad range of pharmacological activities, including anticancer, anti-inflammatory, antioxidant, anti-leishmanial activity, anti-diuretic, antimicrobial, antiparasitic, and some of the derivatives supposed to act as a myocardial infarction, have been observed for pteridine derivatives, an interesting class of privileged heterocycles with promising biological and therapeutic activity [1]. The production of folic acid employs substituted pteridine derivatives as a precursor.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Molecular Docking Studies of Novel Pteridine Derivatives

-¹,

-²,

-³

2022

IJFMR

View full text Add to dashboard Cite

Pteridines are a group of heterocyclic compounds which contain nitrogen as a major heteroatom and it was aromatic compounds that are attached to the pyrazine and pyrimidine ring family. Pteridine derivatives have focused on a specific place in the medicinal chemistry field. The Pteridine ring is present in several natural compounds such as Pterin, Hemiptera (erythropoietin), Biopterin, Neopterin, Xanthopterin, iso-xanthopterin, etc., which include a few heterocyclic compounds like pyrimidine, pyrazine rings. Some vitamins like folic acid and riboflavin and drugs like methotrexate and triamterene. A pteridine is formed by a condensation process. A pteridine is frequently produced using costly and dangerous chemicals. In order to reduce the cost and consumption of hazardous chemicals, novel pteridine compounds were made by mixing a catalyst with a solvent, primary amines, and phenols. Currently, the primary issue limiting a medicine's ability to effectively treat a disease includes the development of resistance. In this article, we will utilise docking studies to provide a thorough explanation of the synthesis of pteridine derivatives and their antioxidant capabilities.

show abstract

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Molecular Docking Studies of Novel Pteridine Derivatives

-¹,

-²,

-³

2022

IJFMR

View full text Add to dashboard Cite

show abstract

“…Heterocyclic pyrimidine nucleus includes four carbon and two nitrogen atoms and is pharmacologically in active; however, its synthetic derivatives have important roles in pharmaceutical applications [1][2][3]. The properties are demonstrated by their hydrogen and bonding systems.…”

Section: Introductionmentioning

confidence: 99%

Reviewing of Synthesis and Computational Studies of Pyrazolo Pyrimidine Derivatives

Mohamed

Ahmed

2019

J. Chem. Rev.

View full text Add to dashboard Cite

In this review we synthesized and conducted a computational studies on Pyrazolo pyrimidine's derivatives that were carried out through density functional theory level utilizing HF/6−311+G**and B3LYP/6−311+G**. Charge transfer occured through molecule was shown by the calculation of HOMO and LUMO energies. The electric dipole moment values (l) of the molecule were counted calculations of DFT. Some geometrical and structural parameters such as total energies (E), relative energies (DE), (bond length in Å, angles in degree), energy gap, relative Gibbs free energy, dipole moment, and molecular electrostatic potentials (MEP) were studied.

show abstract

ChemInform Abstract: Synthesis of Pteridines Derivatives from Different Heterocyclic Compounds

Abstract: Review: 88 refs.

Cited by 2 publications

References 0 publications

Synthesis, Characterization and Molecular Docking Studies of Novel Pteridine Derivatives

Synthesis, Characterization and Molecular Docking Studies of Novel Pteridine Derivatives

Reviewing of Synthesis and Computational Studies of Pyrazolo Pyrimidine Derivatives

Contact Info

Product

Resources

About