A Graphene Oxide–Organic Dye Ionic Complex with DNA‐Sensing and Optical‐Limiting Properties

Balapanuru, Janardhan; Yang, Jiaxiang; Xiao, Si; Bao, Qiaoliang; Jahan, Maryam; Polavarapu, Lakshminarayana; Ji, Wei; Xu, Qing‐Hua; Loh, Kian Ping

doi:10.1002/anie.201001004

Cited by 311 publications

(172 citation statements)

References 27 publications

(28 reference statements)

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“…DNA hybridisation to immobilised ssDNA probes on CVD graphene could be used to detect single base mismatches [114]. Multiple DNA targets and various mismatch DNA strands were also selectively detected with fluorescence microscopy [115][116][117][118]. Fluorescent dyes attached to ssDNA probes adsorbed to a graphene surface were efficiently quenched by graphene oxide, while after hybridization to complementary or mismatched strands, the fluorescent signals reappeared in the dsDNA.…”

Section: Detection Methods Based On Dna Adsorptionmentioning

confidence: 99%

Graphene nanodevices for DNA sequencing

2016

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Fast, cheap, and reliable DNA sequencing could be one of the most disruptive innovations of this decade as it will pave the way for personalised medicine. In pursuit of such technology, a variety of nanotechnology-based approaches have been explored and established including sequencing with nanopores. Due to its unique structure and properties, graphene provides interesting opportunities for the development of a new sequencing technology. In recent years, a wide range of creative ideas for graphene sequencers have been theoretically proposed and the first experimental demonstrations have begun to appear. Here, we review the different approaches to using graphene nanodevices for DNA sequencing, which involve DNA passing through graphene nanopores, nanogaps, and nanoribbons, and the physisorption of DNA on graphene nanostructures. We discuss the advantages and problems of each of these key techniques, and provide a perspective on the use of graphene in future DNA sequencing technology.

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Section: Detection Methods Based On Dna Adsorptionmentioning

confidence: 99%

Graphene nanodevices for DNA sequencing

2016

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“…Ionic complexes have been widely studied for many years [16][17][18] . This complex would change some of the drug properties, including the hydrophilicity/lipophilicity and the drug release rate [19,20] . Ionic complexes can be generated by a variety of chemical bonds, such as hydrogen bonding, electrostatic interactions [21] and van der Waals bonding [22] .…”

Section: Introductionmentioning

confidence: 99%

Development of ionic-complex-based nanostructured lipid carriers to improve the pharmacokinetic profiles of breviscapine

Zheng

Shan

et al. 2013

Acta Pharmacol Sin

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Aim: Breviscapine isolated from the Chinese herb Erigeron breviscapus (Vant) Hand-Mazz is widely used to treat cardiovascular and cerebrovascular diseases. The aim of this study was to improve the pharmacokinetic profiles of breviscapine using nanostructured lipid carrier based on an ionic complex formation. Methods: Breviscapine nanostructured lipid carrier (Bre-NLC) was prepared using the thin film homogenization method. The morphology of Bre-NLCs was determined using transmission electron microscopy. The mean particle size, polydispersity index, zeta-potential analysis and entrapment efficiency were analized. In vitro release was studied using the dialysis method. In vitro stability was studied in fresh plasma and liver slurry of rats. In vivo pharmacokinetics was analyzed in rats after intravenous injection of a dose equivalent to breviscapine (10 mg/kg). Results: The Bre-NLCs were spherical with a mean particle size of ~170 nm, a zeta potential of ~20 mV and a high entrapment efficiency of ~89%. Compared with a commercially available solution, a substantial decrease in the cumulative release of breviscapine was found for the Bre-NLCs. The NLC has a significantly protective effect against the liver enzyme degradation of breviscapine. After intravenous administration in rats, the Bre-NLCs exhibited a 32 times increase in the AUC 0-t and a 12 times increase in T 1/2 as compared to the commercially available breviscapine solution. Conclusion:The results demonstrate that the NLC has great potential to use as a novel sustained release system for breviscapine.

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“…1(a), usually has abundant functional groups which are advantageous for biosensor applications [9,[17][18][19][20][21]. It has been used as a platform for the detection of proteins [24] and DNA [25] by utilizing its good water dispensability, and versatile surface modification. There have many method to evidencing the presence of -COOH, -OH, and C=O groups at the edge of the GO sheet, like infrared spectroscopic, extensive nuclear magnetic resonance, and electron diffraction.The basal plane of GO is covered with mostly epoxide and -COOH groups as shown at Fig.…”

Section: Characterization Of Functionalized Graphene Oxidementioning

confidence: 99%